{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T20:17:44Z","timestamp":1780345064540,"version":"3.54.1"},"reference-count":71,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-11-1-0251"],"award-info":[{"award-number":["W81XWH-11-1-0251"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01 NS053900, 1R01 NS073762"],"award-info":[{"award-number":["1R01 NS053900, 1R01 NS073762"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1U54 CA168512-01"],"award-info":[{"award-number":["1U54 CA168512-01"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Individuals with neurofibromatosis type 1 (NF1) frequently exhibit cognitive and motor impairments and characteristics of autism. The cerebellum plays a critical role in motor control, cognition, and social interaction, suggesting that cerebellar defects likely contribute to NF1-associated neurodevelopmental disorders. Here we show that Nf1 inactivation during early, but not late stages of cerebellar development, disrupts neuronal lamination, which is partially caused by overproduction of glia and subsequent disruption of the Bergmann glia (BG) scaffold. Specific Nf1 inactivation in glutamatergic neuronal precursors causes premature differentiation of granule cell (GC) precursors and ectopic production of unipolar brush cells (UBCs), indirectly disrupting neuronal migration. Transient MEK inhibition during a neonatal window prevents cerebellar developmental defects and improves long-term motor performance of Nf1-deficient mice. This study reveals essential roles of Nf1 in GC\/UBC migration by generating correct numbers of glia and controlling GC\/UBC fate-specification\/differentiation, identifying a therapeutic prevention strategy for multiple NF1-associcated developmental abnormalities.<\/jats:p>","DOI":"10.7554\/elife.05151","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T07:41:27Z","timestamp":1419406887000},"source":"Crossref","is-referenced-by-count":29,"title":["Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1"],"prefix":"10.7554","volume":"3","author":[{"given":"Edward","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States"},{"name":"Gilbert Family Neurofibromatosis Institute, Center for Cancer and Immunology Research and Center for Neuroscience Research, Children's National Medical Center, Washington, United States"},{"name":"Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States"},{"name":"Gilbert Family Neurofibromatosis Institute, Center for Cancer and Immunology Research and Center for Neuroscience Research, Children's National Medical Center, Washington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Bornhorst","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States"},{"name":"Gilbert Family Neurofibromatosis Institute, Center for Cancer and Immunology Research and Center for Neuroscience Research, Children's National Medical Center, Washington, United States"},{"name":"Division of Hematology and Oncology, Department of Pediatrics, Mott Children\u2019s Hospital, University of Michigan, Ann Arbor, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle S","family":"Jecrois","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States"},{"name":"Gilbert Family Neurofibromatosis Institute, Center for Cancer and Immunology Research and Center for Neuroscience Research, Children's National Medical Center, Washington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd E","family":"Anthony","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, Rockefeller University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi E","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Lin","family":"Guan","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States"},{"name":"Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey G","family":"Murphy","sequence":"additional","affiliation":[{"name":"Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, United States"},{"name":"Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States"},{"name":"Gilbert Family Neurofibromatosis Institute, Center for Cancer and Immunology Research and Center for Neuroscience Research, Children's National Medical Center, Washington, United States"},{"name":"Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1136\/jmedgenet-2013-101951","article-title":"Autism traits in the RASopathies","volume":"51","author":"Adviento","year":"2014","journal-title":"Journal of Medical Genetics"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1046\/j.1471-4159.1994.63051880.x","article-title":"A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells","volume":"63","author":"Aruga","year":"1994","journal-title":"Journal of Neurochemistry"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1093\/brain\/121.5.889","article-title":"A clinicopathological study of autism","volume":"121","author":"Bailey","year":"1998","journal-title":"Brain"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.neuron.2008.10.013","article-title":"The mystery and magic of glia: a perspective on their roles in health and disease","volume":"60","author":"Barres","year":"2008","journal-title":"Neuron"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3389\/fnana.2013.00029","article-title":"Congenital hypoplasia of the cerebellum: developmental causes and behavioral consequences","volume":"7","author":"Basson","year":"2013","journal-title":"Frontiers in Neuroanatomy"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1101\/gad.1988010","article-title":"Evidence for and against regional differences in neural stem and progenitor cells of the CNS","volume":"24","author":"Becher","year":"2010","journal-title":"Genes & Development"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1097\/chi.0b013e318030e28b","article-title":"MRI neuroanatomy in young girls with autism: a preliminary study","volume":"46","author":"Bloss","year":"2007","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.pneurobio.2013.08.001","article-title":"Origin, lineage and function of cerebellar glia","volume":"109","author":"Buffo","year":"2013","journal-title":"Progress in Neurobiology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1093\/cercor\/bhl164","article-title":"Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia","volume":"17","author":"Burns","year":"2007","journal-title":"Cerebral Cortex"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1111\/dmcn.12361","article-title":"Relationship between cognitive dysfunction, gait, and motor impairment in children and adolescents with neurofibromatosis type 1","volume":"56","author":"Champion","year":"2014","journal-title":"Developmental Medicine and Child Neurology"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0092-8674(01)00245-8","article-title":"NF1 tumor suppressor gene function: narrowing the GAP","volume":"104","author":"Cichowski","year":"2001","journal-title":"Cell"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1212\/WNL.57.2.245","article-title":"Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study","volume":"57","author":"Courchesne","year":"2001","journal-title":"Neurology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"5584","DOI":"10.1523\/JNEUROSCI.4693-04.2005","article-title":"Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo","volume":"25","author":"Dasgupta","year":"2005","journal-title":"The Journal of Neuroscience"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1523\/JNEUROSCI.2899-04.2005","article-title":"Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex","volume":"25","author":"Englund","year":"2005","journal-title":"The Journal of Neuroscience"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"9184","DOI":"10.1523\/JNEUROSCI.1610-06.2006","article-title":"Unipolar brush cells of the cerebellum are produced in the rhombic lip and migrate through developing white matter","volume":"26","author":"Englund","year":"2006","journal-title":"The Journal of Neuroscience"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/ajmg.a.33139","article-title":"Birth incidence and prevalence of tumor-prone syndromes: estimates from a UK family genetic register service","volume":"152A","author":"Evans","year":"2010","journal-title":"American Journal of Medical Genetics. Part A"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s12311-012-0355-9","article-title":"Consensus paper: pathological role of the cerebellum in autism","volume":"11","author":"Fatemi","year":"2012","journal-title":"The Cerebellum"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1111\/j.1651-2227.2010.01923.x","article-title":"Development of MRI T2 hyperintensities and cognitive functioning in patients with neurofibromatosis type 1","volume":"99","author":"Feldmann","year":"2010","journal-title":"Acta Paediatrica"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1073\/pnas.0605770104","article-title":"Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells","volume":"104","author":"Fogarty","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of USA"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.neuron.2013.10.034","article-title":"Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years","volume":"80","author":"Freeman","year":"2013","journal-title":"Neuron"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"e1642","DOI":"10.1542\/peds.2013-1868","article-title":"Neurofibromatosis type 1 and autism spectrum disorder","volume":"132","author":"Garg","year":"2013a","journal-title":"Pediatrics"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/dmcn.12043","article-title":"Autism and other psychiatric comorbidity in neurofibromatosis type 1: evidence from a population-based study","volume":"55","author":"Garg","year":"2013b","journal-title":"Developmental Medicine and Child Neurology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0165-0270(81)90045-5","article-title":"Analysis of thick brain sections by obverse-reverse computer microscopy: application of a new, high clarity Golgi-Nissl stain","volume":"4","author":"Glaser","year":"1981","journal-title":"Journal of Neuroscience Methods"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.ydbio.2009.02.008","article-title":"Origins and control of the differentiation of inhibitory interneurons and glia in the cerebellum","volume":"328","author":"Grimaldi","year":"2009","journal-title":"Developmental Biology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"pe24","DOI":"10.1126\/scisignal.267pe24","article-title":"The pharmacology of mTOR inhibition","volume":"2","author":"Guertin","year":"2009","journal-title":"Science Signaling"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1146\/annurev.neuro.22.1.511","article-title":"Central nervous system neuronal migration","volume":"22","author":"Hatten","year":"1999","journal-title":"Annual Review of Neuroscience"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.stem.2007.07.008","article-title":"Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms","volume":"1","author":"Hegedus","year":"2007","journal-title":"Cell Stem Cell"},{"key":"bib28","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1242\/dev.125.5.919","article-title":"Progenitors of dorsal commissural interneurons are defined by MATH1 expression","volume":"125","author":"Helms","year":"1998","journal-title":"Development"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1017\/S0012162206002131","article-title":"Learning disabilities in children with neurofibromatosis type 1: subtypes, cognitive profile, and attention-deficit-hyperactivity disorder","volume":"48","author":"Hyman","year":"2006","journal-title":"Developmental Medicine and Child Neurology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1212\/01.wnl.0000179303.72345.ce","article-title":"The nature and frequency of cognitive deficits in children with neurofibromatosis type 1","volume":"65","author":"Hyman","year":"2005","journal-title":"Neurology"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/PEP.0b013e3181f9dbc8","article-title":"Motor proficiency in children with neurofibromatosis type 1","volume":"22","author":"Johnson","year":"2010","journal-title":"Pediatric Physical Therapy"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s12311-010-0217-2","article-title":"Motor learning in children with neurofibromatosis type I","volume":"10","author":"Krab","year":"2011","journal-title":"The cerebellum"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.3791\/990","article-title":"Isolation and culture of post-natal mouse cerebellar granule neuron progenitor cells and neurons","author":"Lee","year":"2009","journal-title":"Journal of Visualized Experiments"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ccr.2012.05.036","article-title":"Innate neural stem cell heterogeneity determines the patterning of glioma formation in children","volume":"22","author":"Lee da","year":"2012","journal-title":"Cancer Cell"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.1101\/gad.1957110","article-title":"Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner","volume":"24","author":"Lee da","year":"2010","journal-title":"Genes & Development"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1469-8749.2012.04399.x","article-title":"Behaviour in children with neurofibromatosis type 1: cognition, executive function, attention, emotion, and social competence","volume":"55","author":"Lehtonen","year":"2013","journal-title":"Developmental Medicine and Child Neurology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1523\/JNEUROSCI.3476-13.2014","article-title":"Shp2-dependent ERK signaling is essential for induction of Bergmann glia and foliation of the cerebellum","volume":"34","author":"Li","year":"2014","journal-title":"The Journal of Neuroscience"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ydbio.2009.02.011","article-title":"Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum","volume":"329","author":"Lin","year":"2009","journal-title":"Developmental Biology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.jpeds.2010.10.001","article-title":"Mental, motor, and language development of toddlers with neurofibromatosis type 1","volume":"158","author":"Lorenzo","year":"2011","journal-title":"The Journal of Pediatrics"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1101\/gad.4.5.683","article-title":"Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development","volume":"4","author":"Martin-Zanca","year":"1990","journal-title":"Genes & Development"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1002\/glia.21236","article-title":"Cerebellar oligodendroglial cells have a mesencephalic origin","volume":"59","author":"Mecklenburg","year":"2011","journal-title":"Glia"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"e101124","DOI":"10.1371\/journal.pone.0101124","article-title":"FGF\/FGFR2 signaling regulates the generation and correct positioning of bergmann glia cells in the developing mouse cerebellum","volume":"9","author":"Meier","year":"2014","journal-title":"PLOS ONE"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.tibs.2011.03.006","article-title":"The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation","volume":"36","author":"Mendoza","year":"2011","journal-title":"Trends in Biochemical Sciences"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1101\/gad.188326.112","article-title":"Astrocytes and disease: a neurodevelopmental perspective","volume":"26","author":"Molofsky","year":"2012","journal-title":"Genes & Development"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/cne.903390203","article-title":"The unipolar brush cell: a neglected neuron of the mammalian cerebellar cortex","volume":"339","author":"Mugnaini","year":"1994","journal-title":"The Journal of Comparative Neurology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.brainresrev.2010.10.001","article-title":"The unipolar brush cell: a remarkable neuron finally receiving deserved attention","volume":"66","author":"Mugnaini","year":"2011","journal-title":"Brain Research Reviews"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainres.2012.04.002","article-title":"Impaired motor coordination and disrupted cerebellar architecture in Fgfr1 and Fgfr2 double knockout mice","volume":"1460","author":"M\u00fcller Smith","year":"2012","journal-title":"Brain Research"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1093\/brain\/awh287","article-title":"Neuropathological findings in autism","volume":"127","author":"Palmen","year":"2004","journal-title":"Brain"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/ajmg.a.36338","article-title":"Longitudinal assessment of cognition and T2-hyperintensities in NF1: an 18-year study","volume":"164A","author":"Payne","year":"2014","journal-title":"American Journal of Medical Genetics Part A"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1002\/ajmg.b.32280","article-title":"Prevalence of autism spectrum disorder symptoms in children with neurofibromatosis type 1","volume":"168","author":"Plasschaert","year":"2014","journal-title":"American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1093\/brain\/awh729","article-title":"Cognition, emotion and the cerebellum","volume":"129","author":"Schmahmann","year":"2006","journal-title":"Brain"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nrc2109","article-title":"Hyperactive Ras in developmental disorders and cancer","volume":"7","author":"Schubbert","year":"2007","journal-title":"Nature Reviews Cancer"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ccr.2008.07.005","article-title":"Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma","volume":"14","author":"Schuller","year":"2008","journal-title":"Cancer Cell"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/nrc1503","article-title":"Targeting the mitogen-activated protein kinase cascade to treat cancer","volume":"4","author":"Sebolt-Leopold","year":"2004","journal-title":"Nature Reviews Cancer"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1146\/annurev.cellbio.23.090506.123237","article-title":"Morphology, molecular codes, and circuitry produce the three-dimensional complexity of the cerebellum","volume":"23","author":"Sillitoe","year":"2007","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain [letter]","volume":"21","author":"Soriano","year":"1999","journal-title":"Nature Genetics"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev.neuro.31.060407.125606","article-title":"Cerebellum and nonmotor function","volume":"32","author":"Strick","year":"2009","journal-title":"Annual Review of Neuroscience"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/nature11310","article-title":"Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice","volume":"488","author":"Tsai","year":"2012","journal-title":"Nature"},{"key":"bib59","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-32864-0","volume-title":"Neurofibromatosis Type 1: Molecular and Cellular Biology","author":"Upadhyaya","year":"2012"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1111\/j.1601-183X.2011.00685.x","article-title":"Motor deficits in neurofibromatosis type 1 mice: the role of the cerebellum","volume":"10","author":"van der Vaart","year":"2011","journal-title":"Genes, Brain, and Behavior"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.20315","article-title":"Neuroglial activation and neuroinflammation in the brain of patients with autism","volume":"57","author":"Vargas","year":"2005","journal-title":"Annals of Neurology"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/dmcn.12038","article-title":"Symptomatology of autism spectrum disorder in a population with neurofibromatosis type 1","volume":"55","author":"Walsh","year":"2013","journal-title":"Developmental Medicine and Child Neurology"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.cell.2012.06.034","article-title":"ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities","volume":"150","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.ccr.2009.04.001","article-title":"Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model","volume":"15","author":"Wang","year":"2009","journal-title":"Cancer Cell"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"17250","DOI":"10.1523\/JNEUROSCI.3938-11.2011","article-title":"Hydrodynamic cellular volume changes enable glioma cell invasion","volume":"31","author":"Watkins","year":"2011","journal-title":"The Journal of Neuroscience"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ccr.2008.07.003","article-title":"Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells","volume":"14","author":"Yang","year":"2008","journal-title":"Cancer Cell"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1242\/dev.063784","article-title":"Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum","volume":"138","author":"Yu","year":"2011","journal-title":"Development"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.1242\/dev.01891","article-title":"PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization","volume":"132","author":"Yue","year":"2005","journal-title":"Development"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"5577","DOI":"10.1242\/dev.02162","article-title":"Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation","volume":"132","author":"Zhu","year":"2005","journal-title":"Development"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/S0092-8674(00)81730-4","article-title":"Smad3 mutant mice develop metastatic colorectal cancer","volume":"94","author":"Zhu","year":"1998","journal-title":"Cell"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1101\/gad.862101","article-title":"Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain","volume":"15","author":"Zhu","year":"2001","journal-title":"Genes & Development"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/elifesciences.org\/lookup\/doi\/10.7554\/eLife.05151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/05151\/elife-05151-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/05151\/elife-05151-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/05151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:49:17Z","timestamp":1697057357000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/05151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,23]]},"references-count":71,"alternative-id":["10.7554\/eLife.05151"],"URL":"https:\/\/doi.org\/10.7554\/elife.05151","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.05151.023","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.05151.022","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,23]]},"article-number":"e05151"}}