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This hyperactivity is caused, at least in part, by decreased Kv7.2\/3 (KCNQ2\/3) potassium currents. However, the biophysical mechanisms underlying resilience to tinnitus, which is observed in noise-exposed mice that do not develop tinnitus (non-tinnitus mice), remain unknown. Our results show that noise exposure induces, on average, a reduction in KCNQ2\/3 channel activity in fusiform cells in noise-exposed mice by 4 days after exposure. Tinnitus is developed in mice that do not compensate for this reduction within the next 3 days. Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2\/3 channel activity and a reduction in HCN channel activity. Our results highlight KCNQ2\/3 and HCN channels as potential targets for designing novel therapeutics that may promote resilience to tinnitus.<\/jats:p>","DOI":"10.7554\/elife.07242","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T07:50:04Z","timestamp":1440661804000},"source":"Crossref","is-referenced-by-count":63,"title":["Noise-induced plasticity of KCNQ2\/3 and HCN channels underlies vulnerability and resilience to tinnitus"],"prefix":"10.7554","volume":"4","author":[{"given":"Shuang","family":"Li","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bopanna I","family":"Kalappa","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology and Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, United 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