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However, a clear effect of sleep deprivation on aggressive behaviors remains unclear. We find that acute sleep deprivation profoundly suppresses aggressive behaviors in the fruit fly, while other social behaviors are unaffected. This suppression is recovered following post-deprivation sleep rebound, and occurs regardless of the approach to achieve sleep loss. Genetic and pharmacologic approaches suggest octopamine signaling transmits changes in aggression upon sleep deprivation, and reduced aggression places sleep-deprived flies at a competitive disadvantage for obtaining a reproductive partner. These findings demonstrate an interaction between two phylogenetically conserved behaviors, and suggest that previous sleep experiences strongly modulate aggression with consequences for reproductive fitness.<\/jats:p>","DOI":"10.7554\/elife.07643","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T04:49:20Z","timestamp":1437972560000},"source":"Crossref","is-referenced-by-count":60,"title":["Sleep deprivation suppresses aggression in Drosophila"],"prefix":"10.7554","volume":"4","author":[{"given":"Matthew S","family":"Kayser","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States"},{"name":"Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States"},{"name":"Penn Chronobiology Program, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United 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