{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:25:30Z","timestamp":1791498330618,"version":"4.3.4"},"reference-count":53,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders (NIDCD)","doi-asserted-by":"publisher","award":["DC13107"],"award-info":[{"award-number":["DC13107"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders (NIDCD)","doi-asserted-by":"publisher","award":["DC000059"],"award-info":[{"award-number":["DC000059"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Auditory function is dependent on the formation of specific innervation patterns between mechanosensory hair cells (HCs) and afferent spiral ganglion neurons (SGNs). In particular, type I SGNs must precisely connect with inner HCs (IHCs) while avoiding connections with nearby outer HCs (OHCs). The factors that mediate these patterning events are largely unknown. Using sparse-labeling and time-lapse imaging, we visualized for the first time the behaviors of developing SGNs including active retraction of processes from OHCs, suggesting that some type I SGNs contact OHCs before forming synapses with IHCs. In addition, we demonstrate that expression of Semaphorin-3F in the OHC region inhibits type I SGN process extension by activating Neuropilin-2 receptors expressed on SGNs. These results suggest a model in which cochlear innervation patterns by type I SGNs are determined, at least in part, through a Semaphorin-3F-mediated inhibitory signal that impedes processes from extending beyond the IHC region.<\/jats:p>","DOI":"10.7554\/elife.07830","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T07:47:09Z","timestamp":1440402429000},"source":"Crossref","is-referenced-by-count":67,"title":["Neuropilin-2\/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons"],"prefix":"10.7554","volume":"4","author":[{"given":"Thomas M","family":"Coate","sequence":"first","affiliation":[{"name":"Laboratory of Cochlear Development, National Institute on Deafness and Other Communication Disorders, Bethesda, United States"},{"name":"Department of Biology, Georgetown University, Washington, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie 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