{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:21:06Z","timestamp":1792110066841,"version":"4.4.0"},"reference-count":73,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T00:00:00Z","timestamp":1749772800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32025014"],"award-info":[{"award-number":["32025014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32330029"],"award-info":[{"award-number":["32330029"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0800200"],"award-info":[{"award-number":["2018YFA0800200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0804000"],"award-info":[{"award-number":["2020YFA0804000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Breast carcinoma amplified sequence 2 (BCAS2), a core component of the hPrP19 complex, plays crucial roles in various physiological and pathological processes. However, whether BCAS2 has functions other than being a key RNA-splicing regulator within the nucleus remains unknown. Here, we show that BCAS2 is essential for primitive hematopoiesis in zebrafish and mouse embryos. The activation of Wnt\/\u03b2-catenin signaling, which is required for hematopoietic progenitor differentiation, is significantly decreased upon depletion of\n                    <jats:italic>bcas2<\/jats:italic>\n                    in zebrafish embryos and mouse embryonic fibroblasts. Interestingly, BCAS2 de\ufb01ciency has no obvious impact on the splicing efficiency of \u03b2-catenin pre-mRNA, while significantly attenuating \u03b2-catenin nuclear accumulation. Moreover, we find that BCAS2 directly binds to \u03b2-catenin via its coiled-coil domains, thereby sequestering \u03b2-catenin within the nucleus. Thus, our results uncover a previously unknown function of BCAS2 in promoting Wnt signaling by enhancing \u03b2-catenin nuclear retention during primitive hematopoiesis.\n                  <\/jats:p>","DOI":"10.7554\/elife.100497","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T10:29:51Z","timestamp":1725877791000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.100497","source":"Crossref","is-referenced-by-count":1,"title":["BCAS2 promotes primitive hematopoiesis by sequestering \u03b2-catenin within the nucleus"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-3007","authenticated-orcid":true,"given":"Guozhu","family":"Ning","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0530pts50","id-type":"ROR","asserted-by":"publisher"}],"name":"Innovation Centre of Ministry of Education for Development and Diseases, the Sixth Affiliated Hospital, School of Medicine, South China University of Technology","place":["Guangzhou, China"]},{"id":[{"id":"https:\/\/ror.org\/057p7h461","id-type":"ROR","asserted-by":"publisher"}],"name":"Affiliated Hospital of Guangdong Medical University & Key Laboratory of Zebrafish Model for Development and Disease of Guangdong Medical University","place":["Zhanjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Yu","family":"Lin","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01kzgyz42","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Pharmacy, Qiqihar Medical University","place":["Qiqihar, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Haixia","family":"Ma","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034t30j35","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Stem Cell and Regeneration, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology, Chinese Academy of Sciences","place":["Beijing, China"]},{"id":[{"id":"https:\/\/ror.org\/05qbk4x57","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034t30j35","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Stem Cell and Regeneration, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology, Chinese Academy of Sciences","place":["Beijing, China"]},{"id":[{"id":"https:\/\/ror.org\/05qbk4x57","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Liping","family":"Yang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0530pts50","id-type":"ROR","asserted-by":"publisher"}],"name":"Innovation Centre of Ministry of Education for Development and Diseases, the Sixth Affiliated Hospital, School of Medicine, South China University of Technology","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"given":"Zhengyu","family":"Liu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0530pts50","id-type":"ROR","asserted-by":"publisher"}],"name":"Innovation Centre of Ministry of Education for Development and Diseases, the Sixth Affiliated Hospital, School of Medicine, South China University of Technology","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5478-5681","authenticated-orcid":true,"given":"Lei","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034t30j35","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Stem Cell and Regeneration, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology, Chinese Academy of Sciences","place":["Beijing, China"]},{"id":[{"id":"https:\/\/ror.org\/05qbk4x57","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Chinese Academy of Sciences","place":["Beijing, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0829-9125","authenticated-orcid":true,"given":"Xinyu","family":"He","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0530pts50","id-type":"ROR","asserted-by":"publisher"}],"name":"Innovation Centre of Ministry of Education for Development and Diseases, the Sixth Affiliated Hospital, School of Medicine, South China University of Technology","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8735-8771","authenticated-orcid":true,"given":"Qiang","family":"Wang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0530pts50","id-type":"ROR","asserted-by":"publisher"}],"name":"Innovation Centre of Ministry of Education for Development and Diseases, the Sixth Affiliated Hospital, School of Medicine, South China University of Technology","place":["Guangzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"6569","DOI":"10.1093\/emboj\/19.23.6569","type":"journal-article","article-title":"Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry","volume":"19","author":"Ajuh","year":"2000","journal-title":"The EMBO Journal"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/s10495-018-1481-8","type":"journal-article","article-title":"Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival","volume":"23","author":"Bissinger","year":"2018","journal-title":"Apoptosis"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1002\/dneu.22517","type":"journal-article","article-title":"Wnt\/\u03b2-catenin signaling during early vertebrate neural development","volume":"77","author":"Brafman","year":"2017","journal-title":"Developmental Neurobiology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/cr.2013.45","type":"journal-article","article-title":"Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos","volume":"23","author":"Chang","year":"2013","journal-title":"Cell Research"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1261\/rna.034835.112","type":"journal-article","article-title":"BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing","volume":"19","author":"Chen","year":"2013","journal-title":"RNA"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-02837-9","type":"journal-article","article-title":"Breast carcinoma-amplified sequence 2 regulates adult neurogenesis via \u03b2-catenin","volume":"13","author":"Chen","year":"2022","journal-title":"Stem Cell Research & Therapy"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1073\/pnas.0307344101","type":"journal-article","article-title":"Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin","volume":"101","author":"Cong","year":"2004","journal-title":"PNAS"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"10713","DOI":"10.1073\/pnas.92.23.10713","type":"journal-article","article-title":"Intraembryonic hematopoietic cell migration during vertebrate development","volume":"92","author":"Detrich","year":"1995","journal-title":"PNAS"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"13507","DOI":"10.1074\/jbc.M109.049411","type":"journal-article","article-title":"Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1","volume":"285","author":"Dimitrova","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"16641","DOI":"10.1074\/jbc.274.23.16641","type":"journal-article","article-title":"The ubiquitin-proteasome pathway and serine kinase activity modulate adenomatous polyposis coli protein-mediated regulation of beta-catenin-lymphocyte enhancer-binding factor signaling","volume":"274","author":"Easwaran","year":"1999","journal-title":"The Journal of Biological Chemistry"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.exphem.2005.06.006","type":"journal-article","article-title":"Blood island formation: longstanding observations and modern interpretations","volume":"33","author":"Ferkowicz","year":"2005","journal-title":"Experimental Hematology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/s0070-2153(03)53004-6","type":"journal-article","article-title":"Ontogeny of hematopoiesis: examining the emergence of hematopoietic cells in the vertebrate embryo","volume":"53","author":"Galloway","year":"2003","journal-title":"Current Topics in Developmental Biology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/s0092-8674(00)00192-6","type":"journal-article","article-title":"Crystal structure of a beta-catenin\/Tcf complex","volume":"103","author":"Graham","year":"2000","journal-title":"Cell"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1128\/MCB.01505-09","type":"journal-article","article-title":"Molecular architecture of the human Prp19\/CDC5L complex","volume":"30","author":"Grote","year":"2010","journal-title":"Molecular and Cellular Biology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/35023605","type":"journal-article","article-title":"Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover","volume":"2","author":"Henderson","year":"2000","journal-title":"Nature Cell Biology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1093\/embo-reports\/kvf181","type":"journal-article","article-title":"The ins and outs of APC and beta-catenin nuclear transport","volume":"3","author":"Henderson","year":"2002","journal-title":"EMBO Reports"},{"key":"bib17","doi-asserted-by":"publisher","DOI":"10.1038\/srep34927","type":"journal-article","article-title":"Conditional knockout of breast carcinoma amplified sequence 2 (BCAS2) in mouse forebrain causes dendritic malformation via \u03b2-catenin","volume":"6","author":"Huang","year":"2016","journal-title":"Scientific Reports"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1074\/jbc.M707578200","type":"journal-article","article-title":"smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta\/nodal signals in zebrafish","volume":"283","author":"Jia","year":"2008","journal-title":"The Journal of Biological Chemistry"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.cellbi.2007.12.008","type":"journal-article","article-title":"Beta-catenin can bind directly to CRM1 independently of adenomatous polyposis coli, which affects its nuclear localization and LEF-1\/beta-catenin-dependent gene expression","volume":"32","author":"Ki","year":"2008","journal-title":"Cell Biology International"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11466","type":"journal-article","article-title":"A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning","volume":"4","author":"Kirl\u0131","year":"2015","journal-title":"eLife"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12026-009-8116-7","type":"journal-article","article-title":"Non-canonical Wnt signaling pathways in hematopoiesis","volume":"46","author":"Kokolus","year":"2010","journal-title":"Immunologic Research"},{"key":"bib22","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56817","type":"journal-article","article-title":"Wnt\/\u03b2-catenin signaling is an evolutionarily conserved determinant of chordate dorsal organizer","volume":"9","author":"Kozmikova","year":"2020","journal-title":"eLife"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.67","type":"journal-article","article-title":"An unexpected role for a Wnt-inhibitor: Dickkopf-1 triggers a novel cancer survival mechanism through modulation of aldehyde-dehydrogenase-1 activity","volume":"5","author":"Krause","year":"2014","journal-title":"Cell Death & Disease"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"3726","DOI":"10.1182\/bloodadvances.2021004845","type":"journal-article","article-title":"Canonical Wnt: a safeguard and threat for erythropoiesis","volume":"5","author":"Krimpenfort","year":"2021","journal-title":"Blood Advances"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"8877","DOI":"10.1158\/0008-5472.CAN-09-2023","type":"journal-article","article-title":"Breast cancer amplified sequence 2, a novel negative regulator of the p53 tumor suppressor","volume":"69","author":"Kuo","year":"2009","journal-title":"Cancer Research"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.stem.2007.10.022","type":"journal-article","article-title":"BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway","volume":"2","author":"Lengerke","year":"2008","journal-title":"Cell Stem Cell"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.ydbio.2004.09.032","type":"journal-article","article-title":"Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos","volume":"277","author":"Leung","year":"2005","journal-title":"Developmental Biology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1083\/jcb.200709091","type":"journal-article","article-title":"Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity","volume":"181","author":"Li","year":"2008","journal-title":"The Journal of Cell Biology"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1242\/dev.01842","type":"journal-article","article-title":"Dissecting Wnt\/beta-catenin signaling during gastrulation using RNA interference in mouse embryos","volume":"132","author":"Lickert","year":"2005","journal-title":"Development"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"3087","DOI":"10.1182\/blood.v98.10.3087","type":"journal-article","article-title":"Morphologic and functional characterization of granulocytes and macrophages in embryonic and adult zebrafish","volume":"98","author":"Lieschke","year":"2001","journal-title":"Blood"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14182","type":"journal-article","article-title":"BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis","volume":"8","author":"Liu","year":"2017","journal-title":"Nature Communications"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1038\/cr.2017.107","type":"journal-article","article-title":"Twa1\/Gid8 is a \u03b2-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis","volume":"27","author":"Lu","year":"2017","journal-title":"Cell Research"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/j.chembiol.2003.11.010","type":"journal-article","article-title":"GSK-3-selective inhibitors derived from Tyrian purple indirubins","volume":"10","author":"Meijer","year":"2003","journal-title":"Chemistry & Biology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/jcb.24803","type":"journal-article","article-title":"Factors affecting the nuclear localization of \u03b2-catenin in normal and malignant tissue","volume":"115","author":"Morgan","year":"2014","journal-title":"Journal of Cellular Biochemistry"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/nrurol.2017.144","type":"journal-article","article-title":"WNT signalling in prostate cancer","volume":"14","author":"Murillo-Garz\u00f3n","year":"2017","journal-title":"Nature Reviews. Urology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.cell.2008.02.008","type":"journal-article","article-title":"Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development","volume":"132","author":"Murry","year":"2008","journal-title":"Cell"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/s0304-3835(99)00091-9","type":"journal-article","article-title":"Identification of a novel gene, DAM1, amplified at chromosome 1p13.3-21 region in human breast cancer cell lines","volume":"140","author":"Nagasaki","year":"1999","journal-title":"Cancer Letters"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/1700","type":"journal-article","article-title":"Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex","volume":"20","author":"Neubauer","year":"1998","journal-title":"Nature Genetics"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"12085","DOI":"10.1073\/pnas.220401797","type":"journal-article","article-title":"Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm","volume":"97","author":"Neufeld","year":"2000","journal-title":"PNAS"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.stem.2007.10.011","type":"journal-article","article-title":"Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood","volume":"2","author":"Nostro","year":"2008","journal-title":"Cell Stem Cell"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1387\/ijdb.093042ep","type":"journal-article","article-title":"Hematopoietic development in the zebrafish","volume":"54","author":"Paik","year":"2010","journal-title":"The International Journal of Developmental Biology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1002\/1873-3468.12459","type":"journal-article","article-title":"Hematopoietic stem cell-independent hematopoiesis: emergence of erythroid, megakaryocyte, and myeloid potential in the mammalian embryo","volume":"590","author":"Palis","year":"2016","journal-title":"FEBS Letters"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.scr.2013.12.003","type":"journal-article","article-title":"The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells","volume":"12","author":"Paluru","year":"2014","journal-title":"Stem Cell Research"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ydbio.2005.10.005","type":"journal-article","article-title":"Cdx4 is a direct target of the canonical Wnt pathway","volume":"289","author":"Pilon","year":"2006","journal-title":"Developmental Biology"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.bbrc.2004.12.187","type":"journal-article","article-title":"Potentiation of estrogen receptor transcriptional activity by breast cancer amplified sequence 2","volume":"328","author":"Qi","year":"2005","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"8299","DOI":"10.1074\/jbc.274.12.8299","type":"journal-article","article-title":"A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity","volume":"274","author":"Rallapalli","year":"1999","journal-title":"The Journal of Biological Chemistry"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/nature18614","type":"journal-article","article-title":"Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification","volume":"535","author":"Reischauer","year":"2016","journal-title":"Nature"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1080\/10409238.2017.1325828","type":"journal-article","article-title":"The role of Wnt signaling in hematopoietic stem cell development","volume":"52","author":"Richter","year":"2017","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1093\/emboj\/cdg105","type":"journal-article","article-title":"Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription","volume":"22","author":"Rosin-Arbesfeld","year":"2003","journal-title":"The EMBO Journal"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20040966","type":"journal-article","article-title":"BCAS2 enhances carcinogenic effects of estrogen receptor alpha in breast cancer cells","volume":"20","author":"Salmer\u00f3n-Hern\u00e1ndez","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"9845","DOI":"10.1128\/MCB.25.22.9845-9858.2005","type":"journal-article","article-title":"Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads","volume":"25","author":"Schmierer","year":"2005","journal-title":"Molecular and Cellular Biology"},{"key":"bib52","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43436-8","type":"journal-article","article-title":"The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish","volume":"9","author":"Stanic","year":"2019","journal-title":"Scientific Reports"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1242\/dev.001123","type":"journal-article","article-title":"Distinct Wnt signaling pathways have opposing roles in appendage regeneration","volume":"134","author":"Stoick-Cooper","year":"2007","journal-title":"Development"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/nbt.2915","type":"journal-article","article-title":"Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells","volume":"32","author":"Sturgeon","year":"2014","journal-title":"Nature Biotechnology"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0311-9","type":"journal-article","article-title":"CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis","volume":"9","author":"Sun","year":"2018","journal-title":"Cell Death & Disease"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081030","type":"journal-article","article-title":"Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation","volume":"8","author":"Tarafdar","year":"2013","journal-title":"PLOS ONE"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"16160","DOI":"10.1073\/pnas.1007725107","type":"journal-article","article-title":"Wnt\/beta-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo","volume":"107","author":"Tran","year":"2010","journal-title":"PNAS"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature05045","type":"journal-article","article-title":"A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula","volume":"443","author":"Vogeli","year":"2006","journal-title":"Nature"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.mod.2014.08.001","type":"journal-article","article-title":"Loss of PiT-1 results in abnormal endocytosis in the yolk sac visceral endoderm","volume":"133","author":"Wallingford","year":"2014","journal-title":"Mechanisms of Development"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1038\/s41416-020-01086-y","type":"journal-article","article-title":"BCAS2, a protein enriched in advanced prostate cancer, interacts with NBS1 to enhance DNA double-strand break repair","volume":"123","author":"Wang","year":"2020","journal-title":"British Journal of Cancer"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/cr.2016.141","type":"journal-article","article-title":"The guanine nucleotide exchange factor Net1 facilitates the specification of dorsal cell fates in zebrafish embryos by promoting maternal \u03b2-catenin activation","volume":"27","author":"Wei","year":"2017","journal-title":"Cell Research"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1089\/zeb.2006.3.465","type":"journal-article","article-title":"ZebraFISH: fluorescent in situ hybridization protocol and three-dimensional imaging of gene expression patterns","volume":"3","author":"Welten","year":"2006","journal-title":"Zebrafish"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/s1074-5521(97)90257-x","type":"journal-article","article-title":"Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA","volume":"4","author":"Wolff","year":"1997","journal-title":"Chemistry & Biology"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/nrm1331","type":"journal-article","article-title":"Nucleocytoplasmic shuttling of signal transducers","volume":"5","author":"Xu","year":"2004","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1242\/dev.129841","type":"journal-article","article-title":"Maternal BCAS2 protects genomic integrity in mouse early embryonic development","volume":"142","author":"Xu","year":"2015","journal-title":"Development"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"R713","DOI":"10.1016\/s0960-9822(01)00417-1","type":"journal-article","article-title":"Heads or tails: Wnts and anterior-posterior patterning","volume":"11","author":"Yamaguchi","year":"2001","journal-title":"Current Biology"},{"key":"bib67","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2022.104495","type":"journal-article","article-title":"Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding","volume":"25","author":"Yang","year":"2022","journal-title":"iScience"},{"key":"bib68","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.107516","type":"journal-article","article-title":"adducin 1 is essential for the survival of erythroid precursors via regulating p53 transcription in zebrafish","volume":"26","author":"Yang","year":"2023","journal-title":"iScience"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1182\/blood-2018-09-876599","type":"journal-article","article-title":"BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis","volume":"133","author":"Yu","year":"2019","journal-title":"Blood"},{"key":"bib70","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00701-5","type":"journal-article","article-title":"Wnt\/\u03b2-catenin signaling in cancers and targeted therapies","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1038\/onc.2016.304","type":"journal-article","article-title":"Wnt signaling in cancer","volume":"36","author":"Zhan","year":"2017","journal-title":"Oncogene"},{"key":"bib72","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101279R","type":"journal-article","article-title":"BCAS2 is involved in alternative splicing and mouse oocyte development","volume":"36","author":"Zhang","year":"2022","journal-title":"The FASEB Journal"},{"key":"dataset1","type":"dataset","article-title":"BCAS2 promotes primitive hematopoiesis by sequestering \u03b2-catenin within the nucleus","volume-title":"NCBI Gene Expression Omnibus","author":"Ning","year":"2025","unstructured":"Ning G, Lin Y. 2025. BCAS2 promotes primitive hematopoiesis by sequestering \u03b2-catenin within the nucleus. NCBI Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE297155. GSE297155."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/100497\/elife-100497-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/100497\/elife-100497-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/100497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:36:36Z","timestamp":1787564196000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/100497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,13]]},"references-count":73,"alternative-id":["10.7554\/eLife.100497"],"URL":"https:\/\/doi.org\/10.7554\/elife.100497","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.07.17.603892","asserted-by":"subject"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.100497.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.100497.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.100497.2","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"accession","id":"GSE297155","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,13]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP100497"}}