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Although the cell wall of the pathogenic yeast\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    is intensively studied, one of the major fibrillar components in its cell wall, \u03b2-1,6-glucan, has been largely neglected. Here, we show that \u03b2-1,6-glucan is essential for bilayered cell wall organization, cell wall integrity, and filamentous growth. For the first time, we show that \u03b2-1,6-glucan production compensates the defect in mannan elongation in the outer layer of the cell wall. In addition, \u03b2-1,6-glucan dynamics are also coordinated by host environmental stimuli and stresses with wall remodeling, where the regulation of \u03b2-1,6-glucan structure and chain length is a crucial process. As we point out that \u03b2-1,6-glucan is exposed at the yeast surface and modulate immune response, \u03b2-1,6-glucan must be considered a key factor in host\u2013pathogen interactions.\n                  <\/jats:p>","DOI":"10.7554\/elife.100569","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T10:26:30Z","timestamp":1725272790000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.100569","source":"Crossref","is-referenced-by-count":19,"title":["\u03b2-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9300-949X","authenticated-orcid":true,"given":"Clara","family":"Bekirian","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/003vg9w96","id-type":"ROR","asserted-by":"publisher"}],"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INRAE, USC2019, Unit\u00e9 Biologie et Pathog\u00e9nicit\u00e9 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