{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:38:38Z","timestamp":1787567918992,"version":"build-2736575974"},"reference-count":43,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS118995"],"award-info":[{"award-number":["R01NS118995"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01CA201068"],"award-info":[{"award-number":["K01CA201068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH077694"],"award-info":[{"award-number":["R01MH077694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS118995"],"award-info":[{"award-number":["R01NS118995"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH077694-S1"],"award-info":[{"award-number":["R01MH077694-S1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH\/NCI","doi-asserted-by":"publisher","award":["K01CA201068"],"award-info":[{"award-number":["K01CA201068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001453","name":"American Brain Tumor Association","doi-asserted-by":"publisher","award":["A131363"],"award-info":[{"award-number":["A131363"]}],"id":[{"id":"10.13039\/100001453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Mutations in Sonic Hedgehog (SHH) signaling pathway genes, for example,\n                    <jats:italic>Suppressor of Fused<\/jats:italic>\n                    (SUFU), drive granule neuron precursors (GNP) to form medulloblastomas (MB\n                    <jats:sup>SHH<\/jats:sup>\n                    ). However, how different molecular lesions in the Shh pathway drive transformation is frequently unclear, and\n                    <jats:italic>SUFU<\/jats:italic>\n                    mutations in the cerebellum seem distinct. In this study, we show that fibroblast growth factor 5 (FGF5) signaling is integral for many infantile MB\n                    <jats:sup>SHH<\/jats:sup>\n                    cases and that\n                    <jats:italic>FGF5<\/jats:italic>\n                    expression is uniquely upregulated in infantile MB\n                    <jats:sup>SHH<\/jats:sup>\n                    tumors. Similarly, mice lacking SUFU (Sufu-cKO) ectopically express\n                    <jats:italic>Fgf5<\/jats:italic>\n                    specifically along the secondary fissure where GNPs harbor preneoplastic lesions and show that FGFR signaling is also ectopically activated in this region. Treatment with an FGFR antagonist rescues the severe GNP hyperplasia and restores cerebellar architecture. Thus, direct inhibition of FGF signaling may be a promising and novel therapeutic candidate for infantile MB\n                    <jats:sup>SHH<\/jats:sup>\n                    .\n                  <\/jats:p>","DOI":"10.7554\/elife.100767","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T12:25:59Z","timestamp":1726143959000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.100767","source":"Crossref","is-referenced-by-count":2,"title":["Aberrant FGF signaling promotes granule neuron precursor expansion in SHH subgroup infantile medulloblastoma"],"prefix":"10.7554","volume":"13","author":[{"given":"Odessa R","family":"Yabut","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco","place":["San Francisco, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Jessica","family":"Arela","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco","place":["San Francisco, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8894-0093","authenticated-orcid":true,"given":"Hector G","family":"Gomez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco","place":["San Francisco, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Jesse Garcia","family":"Castillo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco","place":["San Francisco, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Thomas","family":"Ngo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco","place":["San Francisco, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-1613","authenticated-orcid":true,"given":"Samuel J","family":"Pleasure","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/043mz5j54","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurology, Weill Institute for Neuroscience, University of California San Francisco","place":["San Francisco, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"bib1","type":"dataset","article-title":"Allen institute for brain science","volume-title":"Allen Mouse Brain Atlas","author":"Allen Institute for Brain Science","year":"2004","unstructured":"Allen Institute for Brain Science. 2004. Allen institute for brain science. Allen Mouse Brain Atlas. https:\/\/mouse.brain-map.org\/."},{"key":"bib2","doi-asserted-by":"publisher","first-page":"4180","DOI":"10.1038\/onc.2008.61","type":"journal-article","article-title":"FGF5 as an oncogenic factor in human glioblastoma multiforme","volume":"27","author":"Allerstorfer","year":"2008","journal-title":"Oncogene"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"4753","DOI":"10.1242\/dev.129.20.4753","type":"journal-article","article-title":"Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway","volume":"129","author":"Bai","year":"2002","journal-title":"Development"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","type":"journal-article","article-title":"NCBI GEO: archive for functional genomics data sets--update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Research"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.ccell.2017.05.005","type":"journal-article","article-title":"Intertumoral heterogeneity within medulloblastoma subgroups","volume":"31","author":"Cavalli","year":"2017","journal-title":"Cancer Cell"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1101\/gad.1794109","type":"journal-article","article-title":"Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved","volume":"23","author":"Chen","year":"2009","journal-title":"Genes & Development"},{"key":"bib7","first-page":"1311","type":"journal-article","article-title":"Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5","volume":"8","author":"Clements","year":"1993","journal-title":"Oncogene"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"5581","DOI":"10.1242\/dev.01438","type":"journal-article","article-title":"Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development","volume":"131","author":"Corrales","year":"2004","journal-title":"Development"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"4181","DOI":"10.1038\/onc.2012.440","type":"journal-article","article-title":"Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma","volume":"32","author":"Emmenegger","year":"2013","journal-title":"Oncogene"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2973","DOI":"10.1073\/pnas.0605770104","type":"journal-article","article-title":"Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells","volume":"104","author":"Fogarty","year":"2007","journal-title":"PNAS"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/35009138","type":"journal-article","article-title":"Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development","volume":"404","author":"Gao","year":"2000","journal-title":"Nature"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/hmg\/ddv441","type":"journal-article","article-title":"Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes","volume":"25","author":"Gudernova","year":"2016","journal-title":"Human Molecular Genetics"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1093\/neuonc\/nox228","type":"journal-article","article-title":"Germline SUFU mutation carriers and medulloblastoma: clinical characteristics, cancer risk, and prognosis","volume":"20","author":"Guerrini-Rousseau","year":"2018","journal-title":"Neuro-Oncology"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/s0169-328x(97)00065-x","type":"journal-article","article-title":"Transient expression of FGF-5 mRNA in the rat cerebellar cortex during post-natal development","volume":"47","author":"Hattori","year":"1997","journal-title":"Brain Research. Molecular Brain Research"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1242\/dev.170274","type":"journal-article","article-title":"Suppressor of fused controls cerebellum granule cell proliferation by suppressing Fgf8 and spatially regulating Gli proteins","volume":"147","author":"Jiwani","year":"2020","journal-title":"Development"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1523\/JNEUROSCI.2166-10.2011","type":"journal-article","article-title":"Suppressor of fused controls mid-hindbrain patterning and cerebellar morphogenesis via GLI3 repressor","volume":"31","author":"Kim","year":"2011","journal-title":"The Journal of Neuroscience"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/dvdy.24526","type":"journal-article","article-title":"Suppressor of fused controls cerebellar neuronal differentiation in a manner modulated by GLI3 repressor and Fgf15","volume":"247","author":"Kim","year":"2018","journal-title":"Developmental Dynamics"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.1242\/dev.166892","type":"journal-article","article-title":"Biochemical mechanisms of vertebrate hedgehog signaling","volume":"146","author":"Kong","year":"2019","journal-title":"Development"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.ccr.2014.02.004","type":"journal-article","article-title":"Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition","volume":"25","author":"Kool","year":"2014","journal-title":"Cancer Cell"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s12311-015-0724-2","type":"journal-article","article-title":"Consensus paper: cerebellar development","volume":"15","author":"Leto","year":"2016","journal-title":"Cerebellum"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ydbio.2014.05.014","type":"journal-article","article-title":"Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development","volume":"392","author":"Lin","year":"2014","journal-title":"Developmental Biology"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/leu.2010.6","type":"journal-article","article-title":"gammaH2AX: a sensitive molecular marker of DNA damage and repair","volume":"24","author":"Mah","year":"2010","journal-title":"Leukemia"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1101\/gad.14.8.994","type":"journal-article","article-title":"Induction of medulloblastomas in p53 -null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum","volume":"14","author":"Marino","year":"2000","journal-title":"Genes & Development"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/B978-0-12-385975-4.00010-3","type":"journal-article","article-title":"Sonic hedgehog signaling in the developing CNS where it has been and where it is going","volume":"97","author":"Matise","year":"2011","journal-title":"Current Topics in Developmental Biology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"15292","DOI":"10.1074\/jbc.271.25.15292","type":"journal-article","article-title":"Receptor specificity of the fibroblast growth factor family","volume":"271","author":"Ornitz","year":"1996","journal-title":"The Journal of Biological Chemistry"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/wdev.176","type":"journal-article","article-title":"The fibroblast growth factor signaling pathway","volume":"4","author":"Ornitz","year":"2015","journal-title":"Wiley Interdisciplinary Reviews. Developmental Biology"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"v1","DOI":"10.1093\/neuonc\/now207","type":"journal-article","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2009-2013","volume":"18","author":"Ostrom","year":"2016","journal-title":"Neuro-Oncology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/0169-328x(96)00108-8","type":"journal-article","article-title":"Expression of the fibroblast growth factor family and their receptor family genes during mouse brain development","volume":"41","author":"Ozawa","year":"1996","journal-title":"Brain Research. Molecular Brain Research"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.cell.2009.12.027","type":"journal-article","article-title":"Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate","volume":"140","author":"Pospisilik","year":"2010","journal-title":"Cell"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ccr.2008.07.005","type":"journal-article","article-title":"Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma","volume":"14","author":"Sch\u00fcller","year":"2008","journal-title":"Cancer Cell"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/S1470-2045(17)30243-7","type":"journal-article","article-title":"Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: A cohort study","volume":"18","author":"Schwalbe","year":"2017","journal-title":"The Lancet. Oncology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"3392","DOI":"10.1073\/pnas.1717815115","type":"journal-article","article-title":"Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation","volume":"115","author":"Tan","year":"2018","journal-title":"PNAS"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.ccr.2014.05.005","type":"journal-article","article-title":"Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma","volume":"26","author":"Vanner","year":"2014","journal-title":"Cancer Cell"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41586-019-1158-7","type":"journal-article","article-title":"Childhood cerebellar tumours mirror conserved fetal transcriptional programs","volume":"572","author":"Vladoiu","year":"2019","journal-title":"Nature"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1242\/dev.052126","type":"journal-article","article-title":"Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors","volume":"137","author":"Wang","year":"2010","journal-title":"Development"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3322\/caac.21219","type":"journal-article","article-title":"Childhood and adolescent cancer statistics, 2014","volume":"64","author":"Ward","year":"2014","journal-title":"CA"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1016\/j.celrep.2015.08.031","type":"journal-article","article-title":"Suppressor of fused is critical for maintenance of neuronal progenitor identity during corticogenesis","volume":"12","author":"Yabut","year":"2015","journal-title":"Cell Reports"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"6872","DOI":"10.1523\/JNEUROSCI.2888-19.2020","type":"journal-article","article-title":"The neocortical progenitor specification program is established through combined modulation of SHH and FGF signaling","volume":"40","author":"Yabut","year":"2020","journal-title":"The Journal of Neuroscience"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1002\/dvdy.22013","type":"journal-article","article-title":"Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development","volume":"238","author":"Yaguchi","year":"2009","journal-title":"Developmental Dynamics"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.devcel.2018.11.015","type":"journal-article","article-title":"Dual regulatory functions of SUFU and targetome of GLI2 in SHH subgroup medulloblastoma","volume":"48","author":"Yin","year":"2019","journal-title":"Developmental Cell"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"2957","DOI":"10.1242\/dev.063784","type":"journal-article","article-title":"Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum","volume":"138","author":"Yu","year":"2011","journal-title":"Development"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/gene.10008","type":"journal-article","article-title":"hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo","volume":"31","author":"Zhuo","year":"2001","journal-title":"Genesis"},{"key":"dataset1","type":"dataset","article-title":"Expression data from primary medulloblastoma samples","volume-title":"NCBI Gene Expression Omnibus","author":"Cavalli","year":"2017","unstructured":"Cavalli FM, Remke M, Taylor MD. 2017. Expression data from primary medulloblastoma samples. NCBI Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE85217. GSE85217."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/100767\/elife-100767-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/100767\/elife-100767-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/100767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:54:43Z","timestamp":1787565283000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/100767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,21]]},"references-count":43,"alternative-id":["10.7554\/eLife.100767"],"URL":"https:\/\/doi.org\/10.7554\/elife.100767","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.06.23.449636","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2021.06.23.449636","asserted-by":"object"}],"references":[{"id-type":"accession","id":"GSE85217","asserted-by":"subject"},{"id-type":"uri","id":"https:\/\/mouse.brain-map.org\/","asserted-by":"subject"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.100767.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.100767.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.100767.2","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,21]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP100767"}}