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After exposure to a moving dot sequence, flashing a dot as a cue at the starting point of the sequence can elicit successive elevated responses even in the absence of the sequence. These cue-triggered elevated responses have been shown to play a crucial role in predicting future events in dynamic environments. However, temporal sequences we are exposed to typically contain rich feature information. It remains unknown whether the elevated responses are feature-specific and, more crucially, how the brain organizes sequence information after exposure. To address these questions, participants were exposed to a predefined sequence of four motion directions for about 30 min, followed by the presentation of the start or end motion direction of the sequence as a cue. Surprisingly, we found that cue-triggered elevated responses were not specific to any motion direction. Interestingly, motion direction information was spontaneously reactivated, and the motion sequence was backward replayed in a time-compressed manner. These effects were observed even after brief exposure. Notably, no replay events were observed when the second or third motion direction of the sequence served as a cue. Further analyses revealed that activity in the medial temporal lobe (MTL) preceded the ripple power increase in visual cortex at the onset of replay, implying a coordinated relationship between the activities in the MTL and visual cortex. Together, these findings demonstrate that visual sequence exposure induces twofold brain plasticity that may simultaneously serve for different functional purposes. The non-feature-specific elevated responses may facilitate general processing of upcoming stimuli, whereas the feature-specific backward replay may underpin passive learning of visual sequences.<\/jats:p>","DOI":"10.7554\/elife.101511","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T13:26:21Z","timestamp":1728653181000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.101511","source":"Crossref","is-referenced-by-count":0,"title":["Non-feature-specific elevated responses and feature-specific backward replay in human brain induced by visual sequence exposure"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1009-0500","authenticated-orcid":true,"given":"Tao","family":"He","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03te2zs36","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for the Cognitive Science of Language, Beijing Language and Culture University","place":["Beijing, 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