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Transcranial direct current stimulation (tDCS), a non-invasive neuromodulatory technique, can improve signs of consciousness in disorders of consciousness (DOCs); however, can it influence both conscious and unconscious dynamic functional connectivity? We investigated the modulatory effect of prefrontal cortex (PFC) tDCS on brain dynamics in awake and anesthetized non-human primates using functional MRI. In awake macaques receiving either anodal or cathodal tDCS, we found that cathodal stimulation robustly disrupted the repertoire of functional connectivity patterns, increased structure\u2013function correlation (SFC), decreased Shannon entropy, and favored transitions toward anatomically based patterns. Under deep sedation, anodal tDCS significantly altered brain pattern distribution and reduced SFC. The prefrontal stimulation also modified dynamic connectivity arrangements typically associated with consciousness and unconsciousness. 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