{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:50:23Z","timestamp":1790319023311,"version":"4.1.0"},"reference-count":63,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP190100747"],"award-info":[{"award-number":["DP190100747"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["FT190100697"],"award-info":[{"award-number":["FT190100697"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Wong et al., 2019 used a sensory preconditioning protocol to examine how sensory and fear memories are integrated in the rat medial temporal lobe. In this protocol, rats integrate a sound-light (sensory) memory that forms in stage 1 with a light-shock (fear) memory that forms in stage 2 to generate fear responses (freezing) across test presentations of the sound in stage 3. Here, we advance this research by showing that (1) how\/when rats integrate the sound-light and light-shock memories (online in stage 2 or at test in stage 3) changes with the number of sound-light pairings in stage 1; and (2) regardless of how\/when it occurs, the integration requires communication between two regions of the medial temporal lobe: the perirhinal cortex and basolateral amygdala complex. Thus, \u2018event familiarity\u2019 determines how\/when sensory and fear memories are integrated but not the circuitry by which the integration occurs: this remains the same.<\/jats:p>","DOI":"10.7554\/elife.101965","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T13:26:53Z","timestamp":1726493213000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.101965","source":"Crossref","is-referenced-by-count":7,"title":["Integration of sensory and fear memories in the rat medial temporal lobe"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-9833","authenticated-orcid":true,"given":"Francesca S","family":"Wong","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r8z3t63","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Psychology, University of New South Wales","place":["Sydney, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Alina B","family":"Thomas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r8z3t63","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Psychology, University of New South Wales","place":["Sydney, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"given":"Simon","family":"Killcross","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r8z3t63","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Psychology, University of New South Wales","place":["Sydney, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2333-8437","authenticated-orcid":true,"given":"Vincent","family":"Laurent","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r8z3t63","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Psychology, University of New South Wales","place":["Sydney, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"R Fred","family":"Westbrook","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r8z3t63","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Psychology, University of New South Wales","place":["Sydney, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0592-2026","authenticated-orcid":true,"given":"Nathan M","family":"Holmes","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03r8z3t63","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Psychology, University of New South Wales","place":["Sydney, Australia"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2025,3,19]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"4346","DOI":"10.1523\/JNEUROSCI.0069-09.2009","type":"journal-article","article-title":"Muscarinic receptors in perirhinal cortex control trace conditioning","volume":"29","author":"Bang","year":"2009","journal-title":"The Journal of Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3758\/BF03199061","type":"journal-article","article-title":"Temporal integration in second-order conditioning and sensory preconditioning","volume":"25","author":"Barnet","year":"1997","journal-title":"Animal Learning & Behavior"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.1523\/JNEUROSCI.22-12-05239.2002","type":"journal-article","article-title":"NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala","volume":"22","author":"Bauer","year":"2002","journal-title":"The Journal of Neuroscience"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"9369","DOI":"10.1523\/JNEUROSCI.2153-07.2007","type":"journal-article","article-title":"Gamma oscillations coordinate amygdalo-rhinal interactions during learning","volume":"27","author":"Bauer","year":"2007","journal-title":"The Journal of Neuroscience"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3758\/BF03333608","type":"journal-article","article-title":"Attenuation of overshadowing as a function of nondifferential compound conditioning trials","volume":"18","author":"Bellingham","year":"1981","journal-title":"Bulletin of the Psychonomic Society"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1523\/JNEUROSCI.15-03-02312.1995","type":"journal-article","article-title":"Involvement of subcortical and cortical afferents to the lateral nucleus of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli","volume":"15","author":"Campeau","year":"1995","journal-title":"The Journal of Neuroscience"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1152\/jn.2001.85.4.1661","type":"journal-article","article-title":"Slow and fast (gamma) neuronal oscillations in the perirhinal cortex and lateral amygdala","volume":"85","author":"Collins","year":"2001","journal-title":"Journal of Neurophysiology"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.31234\/osf.io\/c7zyh","type":"preprint","article-title":"Threat learning by proxy: semantic structures facilitate emotional memory integration throughout the MTL and medial prefrontal cortex","volume-title":"PsyArXiv","author":"Cooper","year":"2023"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/s0896-6273(04)00289-2","type":"journal-article","article-title":"Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events","volume":"42","author":"Dolcos","year":"2004","journal-title":"Neuron"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.neuron.2014.04.042","type":"journal-article","article-title":"Amygdala microcircuits controlling learned fear","volume":"82","author":"Duvarci","year":"2014","journal-title":"Neuron"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1093\/cercor\/bhac176","type":"journal-article","article-title":"Second-order fear conditioning involves formation of competing stimulus-danger and stimulus-safety associations","volume":"33","author":"Fam","year":"2023","journal-title":"Cerebral Cortex"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/BF03001163","type":"journal-article","article-title":"Conditional and unconditional components of post-shock freezing","volume":"15","author":"Fanselow","year":"1980","journal-title":"The Pavlovian Journal of Biological Science"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.bbr.2012.02.038","type":"journal-article","article-title":"Basolateral amygdala lesions attenuate safe taste memory-related c-fos expression in the rat perirhinal cortex","volume":"230","author":"G\u00f3mez-Chac\u00f3n","year":"2012","journal-title":"Behavioural Brain Research"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.cub.2021.12.007","type":"journal-article","article-title":"Anterior cingulate neurons signal neutral cue pairings during sensory preconditioning","volume":"32","author":"Hart","year":"2022","journal-title":"Current Biology"},{"key":"bib15","volume-title":"Quantification in Psychology","author":"Hays","year":"1967","type":"book"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1037\/\/0735-7044.108.5.1005","type":"journal-article","article-title":"Effects of muscimol applied to the basolateral amygdala on acquisition and expression of contextual fear conditioning in rats","volume":"108","author":"Helmstetter","year":"1994","journal-title":"Behavioral Neuroscience"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/j.neuroimage.2007.12.043","type":"journal-article","article-title":"Sequence of information processing for emotions through pathways linking temporal and insular cortices with the amygdala","volume":"40","author":"H\u00f6istad","year":"2008","journal-title":"NeuroImage"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0023-9690(81)90022-9","type":"journal-article","article-title":"Acquisition of representation-mediated conditioned food aversions","volume":"12","author":"Holland","year":"1981","journal-title":"Learning and Motivation"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/s0028-3908(98)00038-0","type":"journal-article","article-title":"Amount of training affects associatively-activated event representation","volume":"37","author":"Holland","year":"1998","journal-title":"Neuropharmacology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3758\/BF03193185","type":"journal-article","article-title":"Amount of training effects in representationmediated food aversion learning: No evidence of a role for associability changes","volume":"33","author":"Holland","year":"2005","journal-title":"Learning & Behavior"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1037\/a0014537","type":"journal-article","article-title":"The loss of latent inhibition across compound conditioning","volume":"35","author":"Holmes","year":"2009","journal-title":"Journal of Experimental Psychology. Animal Behavior Processes"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"13112","DOI":"10.1523\/JNEUROSCI.1998-13.2013","type":"journal-article","article-title":"The basolateral amygdala is critical for learning about neutral stimuli in the presence of danger, and the perirhinal cortex is critical in the absence of danger","volume":"33","author":"Holmes","year":"2013","journal-title":"The Journal of Neuroscience"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1101\/lm.044297.116","type":"journal-article","article-title":"A dangerous context changes the way that rats learn about and discriminate between innocuous events in sensory preconditioning","volume":"24","author":"Holmes","year":"2017","journal-title":"Learning & Memory"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0381-17.2017","type":"journal-article","article-title":"Danger changes the way the mammalian brain stores information about innocuous events: a study of sensory preconditioning in rats","volume":"5","author":"Holmes","year":"2018","journal-title":"eNeuro"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104687","type":"journal-article","article-title":"The neural substrates of higher-order conditioning: A review","volume":"138","author":"Holmes","year":"2022","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.neubiorev.2021.10.032","type":"journal-article","article-title":"Not \u201ceither-or\u201d but \u201cwhich-when\u201d: A review of the evidence for integration in sensory preconditioning","volume":"132","author":"Holmes","year":"2022","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"6679","DOI":"10.1523\/JNEUROSCI.0067-23.2023","type":"journal-article","article-title":"NMDA receptors in the basolateral amygdala complex are engaged for pavlovian fear conditioning when an animal\u2019s predictions about danger are in error","volume":"43","author":"Keidar","year":"2023","journal-title":"The Journal of Neuroscience"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1037\/a0012902","type":"journal-article","article-title":"Fear conditioning to discontinuous auditory cues requires perirhinal cortical function","volume":"122","author":"Kholodar-Smith","year":"2008","journal-title":"Behavioral Neuroscience"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1101\/lm.052324.120","type":"journal-article","article-title":"The separate and combined effects of a dangerous context and an epinephrine injection on sensory preconditioning in rats","volume":"28","author":"Kikas","year":"2021","journal-title":"Learning & Memory"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1523\/JNEUROSCI.08-07-02517.1988","type":"journal-article","article-title":"Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear","volume":"8","author":"LeDoux","year":"1988","journal-title":"The Journal of Neuroscience"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3758\/BF03196069","type":"journal-article","article-title":"Temporal integration in Pavlovian appetitive conditioning in rats","volume":"35","author":"Leising","year":"2007","journal-title":"Animal Learning & Behavior"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"3610","DOI":"10.1523\/JNEUROSCI.4839-03.2004","type":"journal-article","article-title":"Perirhinal cortex supports delay fear conditioning to rat ultrasonic social signals","volume":"24","author":"Lindquist","year":"2004","journal-title":"The Journal of Neuroscience"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.nlm.2018.10.009","type":"journal-article","article-title":"The conditions that regulate formation of a false fear memory in rats","volume":"156","author":"Lingawi","year":"2018","journal-title":"Neurobiology of Learning and Memory"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1037\/\/0735-7044.110.6.1365","type":"journal-article","article-title":"N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats","volume":"110","author":"Maren","year":"1996","journal-title":"Behavioral Neuroscience"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/s0301-0082(98)00003-3","type":"journal-article","article-title":"Cortical pathways to the mammalian amygdala","volume":"55","author":"McDonald","year":"1998","journal-title":"Progress in Neurobiology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1002\/(SICI)1096-9861(19960527)369:2<302::AID-CNE10>3.0.CO;2-J","type":"journal-article","article-title":"Efferent projections of the anterior perirhinal cortex in the rat","volume":"369","author":"McIntyre","year":"1996","journal-title":"The Journal of Comparative Neurology"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.771767","type":"journal-article","article-title":"The opioid receptor antagonist naloxone enhances first-order fear conditioning, second-order fear conditioning and sensory preconditioning in rats","volume":"15","author":"Michalscheck","year":"2021","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1111\/1467-8721.ep10772577","type":"journal-article","article-title":"The role of time in elementary associations","volume":"2","author":"Miller","year":"1993","journal-title":"Current Directions in Psychological Science"},{"key":"bib39","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3703","type":"journal-article","article-title":"The amygdala network for processing itch in human brains","volume":"100","author":"Mochizuki","year":"2020","journal-title":"Acta Dermato Venereologica"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"6761","DOI":"10.1523\/JNEUROSCI.4924-05.2006","type":"journal-article","article-title":"Reward association affects neuronal responses to visual stimuli in macaque TE and perirhinal cortices","volume":"26","author":"Mogami","year":"2006","journal-title":"The Journal of Neuroscience"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"17407","DOI":"10.1523\/JNEUROSCI.2878-12.2012","type":"journal-article","article-title":"Stimulus-related activity during conditional associations in monkey perirhinal cortex neurons depends on upcoming reward outcome","volume":"32","author":"Ohyama","year":"2012","journal-title":"The Journal of Neuroscience"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/cne.902050104","type":"journal-article","article-title":"Connections of the amygdala of the rat: IV: Corticoamygdaloid and intraamygdaloid connections as studied with axonal transport of horseradish peroxidase","volume":"205","author":"Ottersen","year":"1982","journal-title":"The Journal of Comparative Neurology"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"12608","DOI":"10.1523\/JNEUROSCI.2949-10.2010","type":"journal-article","article-title":"The basolateral amygdala is critical for the acquisition and extinction of associations between a neutral stimulus and a learned danger signal but not between two neutral stimuli","volume":"30","author":"Parkes","year":"2010","journal-title":"The Journal of Neuroscience"},{"key":"bib44","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2006","type":"book"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/nn1771","type":"journal-article","article-title":"Emotional enhancement of memory via amygdala-driven facilitation of rhinal interactions","volume":"9","author":"Paz","year":"2006","journal-title":"Nature Neuroscience"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1111\/j.1460-9568.2012.08146.x","type":"journal-article","article-title":"Synaptic plasticity from amygdala to perirhinal cortex: a possible mechanism for emotional enhancement of visual recognition memory?","volume":"36","author":"Perugini","year":"2012","journal-title":"The European Journal of Neuroscience"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/j.1749-6632.2000.tb06738.x","type":"journal-article","article-title":"Reciprocal connections between the amygdala and the hippocampal formation, perirhinal cortex, and postrhinal cortex in rat.:A review","volume":"911","author":"Pitk\u00e4nen","year":"2000","journal-title":"Annals of the New York Academy of Sciences"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1523\/JNEUROSCI.1796-22.2023","type":"journal-article","article-title":"Danger changes the way the brain consolidates neutral information; and does so by interacting with processes involved in the encoding of that information","volume":"43","author":"Qureshi","year":"2023","journal-title":"The Journal of Neuroscience"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"2494","DOI":"10.1093\/cercor\/bhm262","type":"journal-article","article-title":"Role of amygdala connectivity in the persistence of emotional memories over time: an event-related FMRI investigation","volume":"18","author":"Ritchey","year":"2008","journal-title":"Cerebral Cortex"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1037\/h0033333","type":"journal-article","article-title":"Associations in second-order conditioning and sensory preconditioning","volume":"81","author":"Rizley","year":"1972","journal-title":"Journal of Comparative and Physiological Psychology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/cne.903030111","type":"journal-article","article-title":"Connections between the central nucleus of the amygdala and the midbrain periaqueductal gray: topography and reciprocity","volume":"303","author":"Rizvi","year":"1991","journal-title":"The Journal of Comparative Neurology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"6889","DOI":"10.1523\/JNEUROSCI.21-17-06889.2001","type":"journal-article","article-title":"Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning","volume":"21","author":"Rodrigues","year":"2001","journal-title":"The Journal of Neuroscience"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuron.2004.09.014","type":"journal-article","article-title":"Molecular mechanisms underlying emotional learning and memory in the lateral amygdala","volume":"44","author":"Rodrigues","year":"2004","journal-title":"Neuron"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/0304-3940(92)90379-l","type":"journal-article","article-title":"Bilateral destruction of neocortical and perirhinal projection targets of the acoustic thalamus does not disrupt auditory fear conditioning","volume":"142","author":"Romanski","year":"1992","journal-title":"Neuroscience Letters"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"11456","DOI":"10.1093\/cercor\/bhad375","type":"journal-article","article-title":"Temporal association activates projections from the perirhinal cortex and ventral CA1 to the prelimbic cortex and from the prelimbic cortex to the basolateral amygdala","volume":"33","author":"Santos","year":"2023","journal-title":"Cerebral Cortex"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"8177","DOI":"10.1523\/JNEUROSCI.20-21-08177.2000","type":"journal-article","article-title":"Activation of ERK\/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning","volume":"20","author":"Schafe","year":"2000","journal-title":"The Journal of Neuroscience"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1002\/(sici)1096-9861(19990412)406:3<299::aid-cne2>3.0.co;2-9","type":"journal-article","article-title":"Perirhinal cortex projections to the amygdaloid complex and hippocampal formation in the rat","volume":"406","author":"Shi","year":"1999","journal-title":"The Journal of Comparative Neurology"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1037\/\/0097-7403.22.4.395","type":"journal-article","article-title":"Backward sensory preconditioning","volume":"22","author":"Ward-Robinson","year":"1996","journal-title":"Journal of Experimental Psychology"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1523\/JNEUROSCI.0236-20.2020","type":"journal-article","article-title":"Central amygdala projections to lateral hypothalamus mediate avoidance behavior in rats","volume":"41","author":"Weera","year":"2021","journal-title":"The Journal of Neuroscience"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"12387","DOI":"10.1523\/JNEUROSCI.4316-06.2006","type":"journal-article","article-title":"Rethinking the fear circuit: the central nucleus of the amygdala is required for the acquisition, consolidation, and expression of Pavlovian fear conditioning","volume":"26","author":"Wilensky","year":"2006","journal-title":"The Journal of Neuroscience"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"4360","DOI":"10.1523\/JNEUROSCI.2156-21.2022","type":"journal-article","article-title":"Prediction error determines whether NMDA receptors in the basolateral amygdala complex are involved in pavlovian fear conditioning","volume":"42","author":"Williams-Spooner","year":"2022","journal-title":"The Journal of Neuroscience"},{"key":"bib62","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.47085","type":"journal-article","article-title":"\u201cOnline\u201d integration of sensory and fear memories in the rat medial temporal lobe","volume":"8","author":"Wong","year":"2019","journal-title":"eLife"},{"key":"dataset1","type":"dataset","article-title":"Integration of sensory and fear memories in the rat medial temporal lobe: advancing research by Wong et al. (2019)","volume-title":"Open Science Framework","author":"Wong","year":"2025","unstructured":"Wong FS, Thomas AB, Killcross AS, Laurent V, Westbrook RF, Holmes NM. 2025. Integration of sensory and fear memories in the rat medial temporal lobe: advancing research by Wong et al. (2019). Open Science Framework. https:\/\/osf.io\/dfg7x\/. dfg7x."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/101965\/elife-101965-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/101965\/elife-101965-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/101965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:48:52Z","timestamp":1787564932000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/101965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":63,"alternative-id":["10.7554\/eLife.101965"],"URL":"https:\/\/doi.org\/10.7554\/elife.101965","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.07.31.605652","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2024.07.31.605652","asserted-by":"object"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.101965.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.101965.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.101965.2","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"accession","id":"dfg7x","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP101965"}}