{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:28:31Z","timestamp":1787567311438,"version":"build-2736575974"},"reference-count":39,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013779","name":"Retina Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013779","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/05n2ytn05","id-type":"ROR","asserted-by":"publisher"}]},{"name":"KYINBRE core facility voucher","award":["P20GM103436"],"award-info":[{"award-number":["P20GM103436"]}]},{"name":"Gertrude Ribble Pilot Grant"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Cone-rod dystrophy (CRD) is a macular degeneration disorder characterized by initial cone cell degeneration. Mutations in CDHR1, a photoreceptor-specific cadherin, have been found to be associated with the incidence of CRD. While studying the function of CDHR1, we observed that the localization of the zebrafish homologue, cdhr1a, resembles that of calyceal process (CPs). When co-labeling CPs using pcdh15b, we observed that cdhr1a, in the outer segment (OS), juxtaposes with pcdh15b, found in the CP. Similar localization patterns were detected in human, macaque, xenopus, ducks, gerbil, and mouse. Using immunoprecipitation and K652 cell aggregation assays, we demonstrate that pcdh15b and cdhr1a can interact and thus potentially link the OS and CP. To analyze the consequences of OS-CP interactions in CRD, we established a\n                    <jats:italic>cdhr1a<\/jats:italic>\n                    mutant line (\n                    <jats:italic>\n                      cdhr1a\n                      <jats:sup>fs*146<\/jats:sup>\n                    <\/jats:italic>\n                    ). Homozygous\n                    <jats:italic>\n                      cdhr1a\n                      <jats:sup>fs*146<\/jats:sup>\n                    <\/jats:italic>\n                    mutants exhibit minor cone OS defects starting at 15 dpf and severe OS disruption and cell loss by 3 months. Shortening of CPs coincided with cone OS defects which were significantly exacerbated when combined with the loss of pcdh15b. Rod OS defects were mild and delayed until 3\u20136 months. In conclusion, we propose that cdhr1a and pcdh15b function to link cone OSs with CPs and maintain OS integrity.\n                  <\/jats:p>","DOI":"10.7554\/elife.102258","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T10:25:17Z","timestamp":1732184717000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.102258","source":"Crossref","is-referenced-by-count":0,"title":["Cdhr1a and pcdh15b may link photoreceptor outer segments with calyceal processes revealing a potential mechanism for cone-rod dystrophy"],"prefix":"10.7554","volume":"13","author":[{"given":"Meet K","family":"Patel","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02k3smh20","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biology, University of Kentucky","place":["Lexington, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Warlen Pereira","family":"Piedade","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02k3smh20","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biology, University of Kentucky","place":["Lexington, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3619-4113","authenticated-orcid":true,"given":"Jakub K","family":"Famulski","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02k3smh20","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biology, University of Kentucky","place":["Lexington, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/(SICI)1097-4644(19960616)61:4%3C514::AID-JCB4%3E3.0.CO;2-R","type":"journal-article","article-title":"Cadherin-catenin complex: protein interactions and their implications for cadherin function","volume":"61","author":"Aberle","year":"1996","journal-title":"Journal of Cellular Biochemistry"},{"key":"bib2","first-page":"71","type":"journal-article","article-title":"World blindness and visual impairment: despite many successes, the problem is growing","volume":"30","author":"Ackland","year":"2017","journal-title":"Community Eye Health"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"4806","DOI":"10.1167\/iovs.16-19687","type":"journal-article","article-title":"Reevaluation of the retinal dystrophy due to recessive alleles of RGR with the discovery of a cis-acting mutation in CDHR1","volume":"57","author":"Arno","year":"2016","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1038\/s41433-020-1045-3","type":"journal-article","article-title":"A clinical study of patients with novel CDHR1 genotypes associated with late-onset macular dystrophy","volume":"35","author":"Ba-Abbad","year":"2021","journal-title":"Eye"},{"key":"bib5","first-page":"929","type":"journal-article","article-title":"Protocadherin-21 (PCDH21), a candidate gene for human retinal dystrophies","volume":"11","author":"Bolz","year":"2005","journal-title":"Molecular Vision"},{"key":"bib6","type":"web-resource","article-title":"RetNet - Retinal Information Network","author":"Bowne","year":"2020","unstructured":"Bowne LS, Diager S. 2020. 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