{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:51:58Z","timestamp":1792165918982,"version":"4.4.0"},"reference-count":55,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-B-108"],"award-info":[{"award-number":["2022-PUMCH-B-108"]}]},{"name":"National Key Research and Development Plan","award":["2024YFA1108900"],"award-info":[{"award-number":["2024YFA1108900"]}]},{"name":"National Key Research and Development Plan","award":["2024YFA1108500"],"award-info":[{"award-number":["2024YFA1108500"]}]},{"name":"Jiangsu Province Science and Technology Special Project (Key Research and Development Plan for Social Development) Funding","award":["BE2023727"],"award-info":[{"award-number":["BE2023727"]}]},{"name":"National Biopharmaceutical Technology Research Project Funding","award":["NCTIB2023XB01011"],"award-info":[{"award-number":["NCTIB2023XB01011"]}]},{"name":"Non-profit Central Research institute Fund of Chinese Academy of Medical Science","award":["2020-PT320-005"],"award-info":[{"award-number":["2020-PT320-005"]}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:sec id=\"abs1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In idiopathic pulmonary fibrosis (IPF) patients, alveolar architectures are lost and gas transfer function would decline, which cannot be rescued by conventional anti-fibrotic therapy. P63+ lung basal progenitor cells are reported to have potential to repair damaged lung epithelium in animal models, which need further investigation in clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We cloned and expanded P63+ progenitor cells from IPF patients to manufacture cell product REGEND001, which were further characterized by morphology and single-cell transcriptomic analysis. Subsequently, an open-label, dose-escalation autologous progenitor cell transplantation clinical trial was conducted. We treated 12 patients with ascending doses of cells: 0.6x, 1x, 2x and 3.3x10\n                      <jats:sup>6<\/jats:sup>\n                      cells\/kg bodyweight. The primary outcome was the incidence and severity of cell therapy-related adverse events (AEs); secondary outcome included other safety and efficacy evaluations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>P63+ basal progenitor cell was safe and tolerated at all doses, with no dose-limiting toxicity or cell therapy-related severe adverse events observed. Patients in three higher dose groups showed significant improvement of lung gas transfer function as well as exercise ability. Resolution of honeycomb lesion was observed in patients of higher dose groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs4\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>REGEND001 has high safety profile and meanwhile encourages further efficacy exploration in IPF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs5\">\n                    <jats:title>Funding:<\/jats:title>\n                    <jats:p>National High Level Hospital Clinical Research Funding (2022-PUMCH-B-108), National Key Research and Development Plan (2024YFA1108900, 2024YFA1108500), Jiangsu Province Science and Technology Special Project Funding (BE2023727), National Biopharmaceutical Technology Research Project Funding (NCTIB2023XB01011), Non-profit Central Research Institute Fund of Chinese Academy of Medical Science (2020-PT320-005), and Regend Therapeutics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"abs6\">\n                    <jats:title>Clinical trial number:<\/jats:title>\n                    <jats:p>\n                      Chinese clinical trial registry:\n                      <jats:related-object document-id=\"CTR20210349\" document-id-type=\"clinical-trial-number\" id=\"RO1\" source-id=\"chinadrugtrials\" source-id-type=\"registry-name\" source-type=\"clinical-trials-registry\" xlink:href=\"http:\/\/www.chinadrugtrials.org.cn\">CTR20210349<\/jats:related-object>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.7554\/elife.102451","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T09:25:30Z","timestamp":1734081930000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.102451","source":"Crossref","is-referenced-by-count":4,"title":["Autologous P63+ lung progenitor cell transplantation in idiopathic pulmonary fibrosis: a phase 1 clinical 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