{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:23:34Z","timestamp":1792815814349,"version":"4.5.0"},"reference-count":129,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds Wetenschappelijk Onderzoek","award":["G0ASQ25N"],"award-info":[{"award-number":["G0ASQ25N"]}]},{"award":["G0ASQ25N"],"award-info":[{"award-number":["G0ASQ25N"]}],"id":[{"id":"https:\/\/ror.org\/03qtxy027","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["ZA1296\/1-1"],"award-info":[{"award-number":["ZA1296\/1-1"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"award":["ZA1296\/1-1"],"award-info":[{"award-number":["ZA1296\/1-1"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]},{"name":"National Institute of General Medical Sciences","award":["GM103440"],"award-info":[{"award-number":["GM103440"]}],"id":[{"id":"https:\/\/ror.org\/04q48ey07","id-type":"ROR","asserted-by":"crossref"}]},{"award":["GM103440"],"award-info":[{"award-number":["GM103440"]}],"id":[{"id":"https:\/\/ror.org\/04q48ey07","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["FO 207\/21"],"award-info":[{"award-number":["FO 207\/21"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"award":["FO 207\/21"],"award-info":[{"award-number":["FO 207\/21"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["FO 207\/16-1"],"award-info":[{"award-number":["FO 207\/16-1"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"award":["FO 207\/16-1"],"award-info":[{"award-number":["FO 207\/16-1"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Deutsche Forschungsgemeinschaft","award":["INST 93\/809-1 FUGG"],"award-info":[{"award-number":["INST 93\/809-1 FUGG"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"crossref"}]},{"award":["INST 93\/809-1 FUGG"],"award-info":[{"award-number":["INST 93\/809-1 FUGG"]}],"id":[{"id":"https:\/\/ror.org\/018mejw64","id-type":"ROR","asserted-by":"publisher"}]},{"name":"National Institute of Neurological Disorders and Stroke","award":["1R01NS136988"],"award-info":[{"award-number":["1R01NS136988"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"crossref"}]},{"award":["1R01NS136988"],"award-info":[{"award-number":["1R01NS136988"]}],"id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Hormones mediate inter-organ signaling, which is crucial in orchestrating diverse behaviors and physiological processes, including sleep and activity, feeding, growth, metabolism, and reproduction. The pars intercerebralis and pars lateralis in insects represent major hubs that contain neurosecretory cells (NSCs) that produce various peptide hormones. To obtain insight into how hormonal signaling is regulated, we have characterized the synaptic connectome of NSCs in the adult\n                    <jats:italic>Drosophila<\/jats:italic>\n                    brain. Identification of neurons providing inputs to multiple NSC classes implicates diuretic hormone 44-expressing NSCs as a major coordinator of physiology and behavior. Surprisingly, despite most NSCs having dendrites in the subesophageal zone (primary taste processing center), inputs from peripheral gustatory neurons to NSCs are largely indirect. We also deciphered pathways via which diverse olfactory inputs are relayed to NSCs. Using an influence metric, based on a linear dynamical systems approach, we identify enteric neurons as the strongest influencers of NSC activity compared to other sensory modalities. Further, our analyses revealed substantial inputs from brain descending neurons to NSCs, suggesting that descending neurons regulate both endocrine and motor output to synchronize physiological changes with appropriate behaviors. In contrast to NSC inputs, synaptic output from NSCs is sparse and mostly mediated by corazonin NSCs. We show that both corazonin-expressing NSCs and their downstream synaptic partner DNg27 influence egg-laying. We additionally explore putative paracrine interconnectivity between NSC classes and peptide hormone pathways from NSCs to peripheral tissues by analyzing single-cell transcriptomic datasets. Our comprehensive characterization of the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    neurosecretory network connectome provides a platform to understand complex hormonal networks and how they orchestrate animal behaviors and physiology.\n                  <\/jats:p>","DOI":"10.7554\/elife.102684","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T11:25:20Z","timestamp":1731583520000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.102684","source":"Crossref","is-referenced-by-count":9,"title":["Synaptic connectome of a neurosecretory network in the Drosophila brain"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8501-6487","authenticated-orcid":true,"given":"Theresa H","family":"McKim","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Integrative Neuroscience Program, University of Nevada Reno","place":["Reno, United States"]},{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biology, University of Nevada Reno","place":["Reno, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4744-1546","authenticated-orcid":true,"given":"Jayati","family":"Gera","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05f950310","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biology, KU Leuven","place":["Leuven, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Ariana J","family":"Gayban","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Integrative Neuroscience Program, University of Nevada Reno","place":["Reno, United States"]},{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry and Molecular Biology, University of Nevada Reno","place":["Reno, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3730-3617","authenticated-orcid":true,"given":"Kevin","family":"Christie","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Integrative Neuroscience Program, University of Nevada Reno","place":["Reno, United States"]},{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Mechanical Engineering, University of Nevada Reno","place":["Reno, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Joel","family":"Shin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry and Molecular Biology, University of Nevada Reno","place":["Reno, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7989-7150","authenticated-orcid":true,"given":"Nils","family":"Reinhard","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5954-5919","authenticated-orcid":true,"given":"Giulia","family":"Manoli","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Selina","family":"Hilpert","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Patrick","family":"Callaerts","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05f950310","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Human Genetics, KU Leuven","place":["Leuven, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6538-7179","authenticated-orcid":true,"given":"Floris","family":"van Breugel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Integrative Neuroscience Program, University of Nevada Reno","place":["Reno, United States"]},{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Mechanical Engineering, University of Nevada Reno","place":["Reno, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0859-9092","authenticated-orcid":true,"given":"Charlotte","family":"Helfrich-F\u00f6rster","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6498-2208","authenticated-orcid":true,"given":"Meet","family":"Zandawala","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Integrative Neuroscience Program, University of Nevada Reno","place":["Reno, United States"]},{"id":[{"id":"https:\/\/ror.org\/00fbnyb24","id-type":"ROR","asserted-by":"publisher"}],"name":"Neurobiology and Genetics, Theodor-Boveri Institute, Biocenter, University of W\u00fcrzburg","place":["W\u00fcrzburg, Germany"]},{"id":[{"id":"https:\/\/ror.org\/05f950310","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biology, KU Leuven","place":["Leuven, Belgium"]},{"id":[{"id":"https:\/\/ror.org\/01keh0577","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry and Molecular Biology, University of Nevada Reno","place":["Reno, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.247668","type":"journal-article","article-title":"Another fly diuretic hormone: tachykinins increase fluid and ion transport by adult Drosophila melanogaster Malpighian \u201crenal\u201d tubules","volume":"227","author":"Agard","year":"2024","journal-title":"The Journal of Experimental Biology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0006-8993(93)90451-r","type":"journal-article","article-title":"Electrotonic coupling between neurosecretory cells in the crayfish eyestalk","volume":"613","author":"Alvarado Alv\u00e1rez","year":"1993","journal-title":"Brain Research"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1340432","type":"journal-article","article-title":"Recent insights into the role of hormones during development and their functional regulation","volume":"15","author":"Aref","year":"2024","journal-title":"Frontiers in Endocrinology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/bies.201100185","type":"journal-article","article-title":"Beyond the connectome: how neuromodulators shape neural circuits","volume":"34","author":"Bargmann","year":"2012","journal-title":"BioEssays"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.53350","type":"journal-article","article-title":"The natverse, a versatile toolbox for combining and analysing neuroanatomical data","volume":"9","author":"Bates","year":"2020","journal-title":"eLife"},{"key":"bib6","type":"software","article-title":"ConnectomeInfluenceCalculator","volume-title":"GitHub","author":"Bates","year":"2026","unstructured":"Bates A. 2026. ConnectomeInfluenceCalculator. GitHub. 57cc08c. https:\/\/github.com\/DrugowitschLab\/ConnectomeInfluenceCalculator."},{"key":"bib7","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1038\/s41586-026-10735-w","type":"journal-article","article-title":"Distributed control circuits across a brain-and-cord connectome","volume":"656","author":"Bates","year":"2026","journal-title":"Nature"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"5504","DOI":"10.1016\/j.cell.2026.08.015","type":"journal-article","article-title":"Sexual dimorphism in the complete Drosophila male central nervous system connectome","volume":"189","author":"Berg","year":"2026","journal-title":"Cell"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002631","type":"journal-article","article-title":"Fine-scale mapping of natural variation in fly fecundity identifies neuronal domain of expression and function of an aquaporin","volume":"8","author":"Bergland","year":"2012","journal-title":"PLOS Genetics"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"18321","DOI":"10.1073\/pnas.1318119110","type":"journal-article","article-title":"Regulation of onset of female mating and sex pheromone production by juvenile hormone in Drosophila melanogaster","volume":"110","author":"Bilen","year":"2013","journal-title":"PNAS"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.1172\/JCI60047","type":"journal-article","article-title":"Mechanisms of thyroid hormone action","volume":"122","author":"Brent","year":"2012","journal-title":"The Journal of Clinical Investigation"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1242\/jeb.205.24.3799","type":"journal-article","article-title":"The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP","volume":"205","author":"Cabrero","year":"2002","journal-title":"The Journal of Experimental Biology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.peptides.2016.02.004","type":"journal-article","article-title":"The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster","volume":"80","author":"Cannell","year":"2016","journal-title":"Peptides"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"3359","DOI":"10.1002\/cne.22405","type":"journal-article","article-title":"Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits","volume":"518","author":"Carlsson","year":"2010","journal-title":"The Journal of Comparative Neurology"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201947903","type":"journal-article","article-title":"Inter-organ communication: a gatekeeper for metabolic health","volume":"20","author":"Castillo-Armengol","year":"2019","journal-title":"EMBO Reports"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/ng2049","type":"journal-article","article-title":"Using FlyAtlas to identify better Drosophila melanogaster models of human disease","volume":"39","author":"Chintapalli","year":"2007","journal-title":"Nature Genetics"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.neuron.2020.08.005","type":"journal-article","article-title":"A systematic nomenclature for the Drosophila ventral nerve cord","volume":"107","author":"Court","year":"2020","journal-title":"Neuron"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.02.610892","type":"preprint","article-title":"A gut-brain-gut interoceptive circuit loop gates sugar ingestion in Drosophila","volume-title":"bioRxiv","author":"Cui","year":"2024"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.cell.2018.05.057","type":"journal-article","article-title":"A single-cell transcriptome atlas of the aging Drosophila brain","volume":"174","author":"Davie","year":"2018","journal-title":"Cell"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1038\/s41592-021-01330-0","type":"journal-article","article-title":"FlyWire: online community for whole-brain connectomics","volume":"19","author":"Dorkenwald","year":"2022","journal-title":"Nature Methods"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41586-024-07558-y","type":"journal-article","article-title":"Neuronal wiring diagram of an adult brain","volume":"634","author":"Dorkenwald","year":"2024","journal-title":"Nature"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1146\/annurev-genet-121415-122024","type":"journal-article","article-title":"Interorgan communication pathways in physiology: focus on Drosophila","volume":"50","author":"Droujinine","year":"2016","journal-title":"Annual Review of Genetics"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.neuron.2015.05.032","type":"journal-article","article-title":"Nutrient sensor in the brain directs the action of the brain-gut axis in Drosophila","volume":"87","author":"Dus","year":"2015","journal-title":"Neuron"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1016\/j.cell.2024.03.016","type":"journal-article","article-title":"Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster","volume":"187","author":"Eckstein","year":"2024","journal-title":"Cell"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nrg1989","type":"journal-article","article-title":"How flies get their size: genetics meets physiology","volume":"7","author":"Edgar","year":"2006","journal-title":"Nature Reviews. Genetics"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1210\/jcem.84.6.5367","type":"journal-article","article-title":"Stress and the reproductive cycle","volume":"84","author":"Ferin","year":"1999","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.conb.2015.06.001","type":"journal-article","article-title":"Molecular neurobiology of Drosophila taste","volume":"34","author":"Freeman","year":"2015","journal-title":"Current Opinion in Neurobiology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/27376","type":"journal-article","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"Friedman","year":"1998","journal-title":"Nature"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.cub.2014.12.058","type":"journal-article","article-title":"Drosophila sugar receptors in sweet taste perception, olfaction, and internal nutrient sensing","volume":"25","author":"Fujii","year":"2015","journal-title":"Current Biology"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"12323","DOI":"10.1073\/pnas.92.26.12323","type":"journal-article","article-title":"Isolation and identification of a diuretic hormone from the mealworm Tenebrio molitor","volume":"92","author":"Furuya","year":"1995","journal-title":"PNAS"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47465-4","type":"journal-article","article-title":"Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY\/NPF secretion","volume":"15","author":"Gao","year":"2024","journal-title":"Nature Communications"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.97043","type":"journal-article","article-title":"Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila","volume":"13","author":"Gera","year":"2025","journal-title":"eLife"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.64898\/2025.12.14.694216","type":"preprint","article-title":"Connectomic mapping of pharyngeal and gut sensory circuits in adult Drosophila","volume-title":"bioRxiv","author":"Giakoumas","year":"2025"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1210\/jc.2008-2291","type":"journal-article","article-title":"Prevalence and incidence of endocrine and metabolic disorders in the United States: a comprehensive review","volume":"94","author":"Golden","year":"2009","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1093\/bioinformatics\/btu393","type":"journal-article","article-title":"circlize Implements and enhances circular visualization in R","volume":"30","author":"Gu","year":"2014","journal-title":"Bioinformatics"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s41586-020-2866-8","type":"journal-article","article-title":"Enteric neurons increase maternal food intake during reproduction","volume":"587","author":"Hadjieconomou","year":"2020","journal-title":"Nature"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7800","type":"journal-article","article-title":"Tracing the evolutionary origins of insect renal function","volume":"6","author":"Halberg","year":"2015","journal-title":"Nature Communications"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","type":"journal-article","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1677\/joe.1.06964","type":"journal-article","article-title":"The neuroendocrine system of invertebrates: a developmental and evolutionary perspective","volume":"190","author":"Hartenstein","year":"2006","journal-title":"The Journal of Endocrinology"},{"key":"bib40","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2022.788633","type":"journal-article","article-title":"Olfactory senses modulate food consumption and physiology in Drosophila melanogaster","volume":"16","author":"He","year":"2022","journal-title":"Frontiers in Behavioral Neuroscience"},{"key":"bib41","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.99548","type":"journal-article","article-title":"Aminergic and peptidergic modulation of insulin-producing cells in Drosophila","volume":"13","author":"Held","year":"2025","journal-title":"eLife"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/cphy.c150015","type":"journal-article","article-title":"Regulation of the hypothalamic-pituitary-adrenocortical stress response","volume":"6","author":"Herman","year":"2016","journal-title":"Comprehensive Physiology"},{"key":"bib43","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65745","type":"journal-article","article-title":"Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila","volume":"10","author":"H\u00fcckesfeld","year":"2021","journal-title":"eLife"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nmeth.2765","type":"journal-article","article-title":"Optogenetic control of Drosophila using a red-shifted channelrhodopsin reveals experience-dependent influences on courtship","volume":"11","author":"Inagaki","year":"2014","journal-title":"Nature Methods"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"R531","DOI":"10.1152\/ajpregu.00158.2004","type":"journal-article","article-title":"AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila","volume":"288","author":"Isabel","year":"2005","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"bib46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011480","type":"journal-article","article-title":"Metabolic stress responses in Drosophila are modulated by brain neurosecretory cells that produce multiple neuropeptides","volume":"5","author":"Kahsai","year":"2010","journal-title":"PLOS ONE"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.1007\/s00018-012-1097-z","type":"journal-article","article-title":"Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin","volume":"69","author":"Kapan","year":"2012","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1146\/annurev-neuro-072116-031558","type":"journal-article","article-title":"Neuromodulation of innate behaviors in Drosophila","volume":"40","author":"Kim","year":"2017","journal-title":"Annual Review of Neuroscience"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/s42255-024-01020-z","type":"journal-article","article-title":"Postprandial sodium sensing by enteric neurons in Drosophila","volume":"6","author":"Kim","year":"2024","journal-title":"Nature Metabolism"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52807-3","type":"journal-article","article-title":"A sexually transmitted sugar orchestrates reproductive responses to nutritional stress","volume":"15","author":"Kim","year":"2024","journal-title":"Nature Communications"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1016\/j.cub.2017.05.089","type":"journal-article","article-title":"A peptidergic circuit links the circadian clock to locomotor activity","volume":"27","author":"King","year":"2017","journal-title":"Current Biology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.conb.2015.06.009","type":"journal-article","article-title":"Pheromone processing in Drosophila","volume":"34","author":"Kohl","year":"2015","journal-title":"Current Opinion in Neurobiology"},{"key":"bib53","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25445-2","type":"journal-article","article-title":"A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila","volume":"12","author":"Koyama","year":"2021","journal-title":"Nature Communications"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1152\/physiol.00030.2024","type":"journal-article","article-title":"The integrative physiology of hormone signaling: insights from insect models","volume":"40","author":"Koyama","year":"2025","journal-title":"Physiology"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.160152","type":"journal-article","article-title":"Systemic corazonin signalling modulates stress responses and metabolism in Drosophila","volume":"6","author":"Kubrak","year":"2016","journal-title":"Open Biology"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1242\/dev.201186","type":"journal-article","article-title":"Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum","volume":"150","author":"Kurogi","year":"2023","journal-title":"Development"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.cub.2015.01.050","type":"journal-article","article-title":"A neuronal pathway that controls sperm ejection and storage in female Drosophila","volume":"25","author":"Lee","year":"2015","journal-title":"Current Biology"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"209","DOI":"10.5483\/BMBRep.2023-0021","type":"journal-article","article-title":"The role of diuretic hormones (DHs) and their receptors in Drosophila","volume":"56","author":"Lee","year":"2023","journal-title":"BMB Reports"},{"key":"bib59","doi-asserted-by":"publisher","DOI":"10.1126\/science.abk2432","type":"journal-article","article-title":"Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly","volume":"375","author":"Li","year":"2022","journal-title":"Science"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.cub.2022.12.005","type":"journal-article","article-title":"Behavioral state-dependent modulation of insulin-producing cells in Drosophila","volume":"33","author":"Liessem","year":"2023","journal-title":"Current Biology"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/s41586-022-04408-7","type":"journal-article","article-title":"A nutrient-specific gut hormone arbitrates between courtship and feeding","volume":"602","author":"Lin","year":"2022","journal-title":"Nature"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41586-024-07968-y","type":"journal-article","article-title":"Network statistics of the whole-brain connectome of Drosophila","volume":"634","author":"Lin","year":"2024","journal-title":"Nature"},{"key":"bib63","doi-asserted-by":"publisher","DOI":"10.64898\/2026.07.28.740380","type":"preprint","article-title":"Neural control of respiration in Drosophila","volume-title":"bioRxiv","author":"Luo","year":"2026"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1007\/s00018-015-1884-4","type":"journal-article","article-title":"Food odors trigger an endocrine response that affects food ingestion and metabolism","volume":"72","author":"Lushchak","year":"2015","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1210\/en.2005-1523","type":"journal-article","article-title":"The impact of stress on reproduction: are glucocorticoids inhibitory or protective to gonadotropin secretion?","volume":"147","author":"Maeda","year":"2006","journal-title":"Endocrinology"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuron.2012.09.010","type":"journal-article","article-title":"Neuromodulation of neuronal circuits: back to the future","volume":"76","author":"Marder","year":"2012","journal-title":"Neuron"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.devcel.2007.11.003","type":"journal-article","article-title":"Prothoracicotropic hormone regulates developmental timing and body size in Drosophila","volume":"13","author":"McBrayer","year":"2007","journal-title":"Developmental Cell"},{"key":"bib68","type":"software","article-title":"McKim-et-al-2026-synaptic-connectome-of-a-neurosecretory-network-in-the-drosophila-brain","author":"McKim","year":"2026","unstructured":"McKim TH. 2026. McKim-et-al-2026-synaptic-connectome-of-a-neurosecretory-network-in-the-drosophila-brain. Software Heritage. swh:1:rev:c66280eb8f43ae5c2f772549c4a719bccd56950a. https:\/\/archive.softwareheritage.org\/swh:1:dir:b4351be98cde106f67c118ddabf510ae39a179b1;origin=https:\/\/github.com\/Zandawala-lab\/McKim-et-al-2026-Synaptic-connectome-of-a-neurosecretory-network-in-the-Drosophila-brain;visit=swh:1:snp:e7ca1ae3dec6aba46e9b6df4e121ac41e2ad70d9;anchor=swh:1:rev:c66280eb8f43ae5c2f772549c4a719bccd56950a."},{"key":"bib69","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/BF02935638","type":"journal-article","article-title":"Gene expression and chemical diversity in hypothalamic neurosecretory neurons","volume":"7","author":"Meister","year":"1993","journal-title":"Molecular Neurobiology"},{"key":"bib70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030305","type":"journal-article","article-title":"Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain","volume":"3","author":"Melcher","year":"2005","journal-title":"PLOS Biology"},{"key":"bib71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0040068","type":"journal-article","article-title":"Neuromedin U and its putative Drosophila homolog hugin","volume":"4","author":"Melcher","year":"2006","journal-title":"PLOS Biology"},{"key":"bib72","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63049","type":"journal-article","article-title":"Control of feeding by Piezo-mediated gut mechanosensation in Drosophila","volume":"10","author":"Min","year":"2021","journal-title":"eLife"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"19","DOI":"10.4161\/fly.27241","type":"journal-article","article-title":"Diverse roles for the Drosophila fructose sensor Gr43a","volume":"8","author":"Miyamoto","year":"2014","journal-title":"Fly"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/dgd.12733","type":"journal-article","article-title":"A population of neurons that produce hugin and express the diuretic hormone 44 receptor gene projects to the corpora allata in Drosophila melanogaster","volume":"63","author":"Mizuno","year":"2021","journal-title":"Development, Growth & Differentiation"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1038\/nature05484","type":"journal-article","article-title":"Gut hormones and the regulation of energy homeostasis","volume":"444","author":"Murphy","year":"2006","journal-title":"Nature"},{"key":"bib76","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34272","type":"journal-article","article-title":"The functional organization of descending sensory-motor pathways in Drosophila","volume":"7","author":"Namiki","year":"2018","journal-title":"eLife"},{"key":"bib77","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00252","type":"journal-article","article-title":"Factors that regulate insulin producing cells and their output in Drosophila","volume":"4","author":"N\u00e4ssel","year":"2013","journal-title":"Frontiers in Physiology"},{"key":"bib78","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.02.003","type":"journal-article","article-title":"Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior","volume":"179","author":"N\u00e4ssel","year":"2019","journal-title":"Progress in Neurobiology"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00441-020-03264-z","type":"journal-article","article-title":"Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions","volume":"382","author":"N\u00e4ssel","year":"2020","journal-title":"Cell and Tissue Research"},{"key":"bib80","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04214-4","type":"journal-article","article-title":"Cholecystokinin\/sulfakinin peptide signaling: conserved roles at the intersection between feeding, mating and aggression","volume":"79","author":"N\u00e4ssel","year":"2022","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib81","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.220174","type":"journal-article","article-title":"Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions","volume":"12","author":"N\u00e4ssel","year":"2022","journal-title":"Open Biology"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00441-024-03936-0","type":"journal-article","article-title":"A brief history of insect neuropeptide and peptide hormone research","volume":"399","author":"N\u00e4ssel","year":"2025","journal-title":"Cell and Tissue Research"},{"key":"bib83","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/s41586-019-1675-4","type":"journal-article","article-title":"A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila","volume":"574","author":"Oh","year":"2019","journal-title":"Nature"},{"key":"bib84","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1016\/j.neuron.2021.04.028","type":"journal-article","article-title":"Periphery signals generated by Piezo-mediated stomach stretch and Neuromedin-mediated glucose load regulate the Drosophila brain nutrient sensor","volume":"109","author":"Oh","year":"2021","journal-title":"Neuron"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/cne.24410","type":"journal-article","article-title":"Adult-specific insulin-producing neurons in Drosophila melanogaster","volume":"526","author":"Ohhara","year":"2018","journal-title":"The Journal of Comparative Neurology"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4093\/dmj.2013.37.1.1","type":"journal-article","article-title":"AMPK and exercise: glucose uptake and insulin sensitivity","volume":"37","author":"O\u2019Neill","year":"2013","journal-title":"Diabetes & Metabolism Journal"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0006-8993(86)90639-6","type":"journal-article","article-title":"Electrical coupling and gap junctions between neurosecretory cells in an insect","volume":"397","author":"Orchard","year":"1986","journal-title":"Brain Research"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.jinsphys.2011.11.020","type":"journal-article","article-title":"Natriuresis and diuretic hormone synergism in R. prolixus upper Malpighian tubules is inhibited by the anti-diuretic hormone, RhoprCAPA-\u03b12","volume":"58","author":"Paluzzi","year":"2012","journal-title":"Journal of Insect Physiology"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"T41","DOI":"10.1530\/JOE-15-0113","type":"journal-article","article-title":"60 years of neuroendocrinology: The hypothalamo-pituitary-gonadal axis","volume":"226","author":"Plant","year":"2015","journal-title":"The Journal of Endocrinology"},{"key":"bib90","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.108551","type":"journal-article","article-title":"Hugin-AstA circuitry is a novel central energy sensor that directly regulates sweet sensation in Drosophila and mouse","volume":"14","author":"Qin","year":"2026","journal-title":"eLife"},{"key":"bib91","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54694-0","type":"journal-article","article-title":"Synaptic connectome of the Drosophila circadian clock","volume":"15","author":"Reinhard","year":"2024","journal-title":"Nature Communications"},{"key":"bib92","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1152\/physrev.00028.2005","type":"journal-article","article-title":"Dynamic sensorimotor interactions in locomotion","volume":"86","author":"Rossignol","year":"2006","journal-title":"Physiological Reviews"},{"key":"bib93","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.66018","type":"journal-article","article-title":"Information flow, cell types and stereotypy in a full olfactory connectome","volume":"10","author":"Schlegel","year":"2021","journal-title":"eLife"},{"key":"bib94","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/s41586-024-07686-5","type":"journal-article","article-title":"Whole-brain annotation and multi-connectome cell typing of Drosophila","volume":"634","author":"Schlegel","year":"2024","journal-title":"Nature"},{"key":"bib95","type":"software","article-title":"Navis","volume-title":"GitHub","author":"Schlegel","year":"2026","unstructured":"Schlegel P. 2026. Navis. GitHub. cb9a591. https:\/\/github.com\/navis-org\/navis."},{"key":"bib96","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1146\/annurev-ento-031616-035500","type":"journal-article","article-title":"Neuropeptides as regulators of behavior in insects","volume":"62","author":"Schoofs","year":"2017","journal-title":"Annual Review of Entomology"},{"key":"bib97","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101108","type":"journal-article","article-title":"Non-canonical eclosion hormone-expressing cells regulate Drosophila ecdysis","volume":"23","author":"Scott","year":"2020","journal-title":"iScience"},{"key":"bib98","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/1096-9861(20010319)431:4<481::aid-cne1084>3.0.co;2-7","type":"journal-article","article-title":"Innervation of the ring gland of Drosophila melanogaster","volume":"431","author":"Siegmund","year":"2001","journal-title":"The Journal of Comparative Neurology"},{"key":"bib99","type":"software","article-title":"Cloud-volume","volume-title":"GitHub","author":"Silversmith","year":"2026","unstructured":"Silversmith W. 2026. Cloud-volume. GitHub. 8edb582. https:\/\/github.com\/seung-lab\/cloud-volume."},{"key":"bib100","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2012.00109","type":"journal-article","article-title":"Insulin-producing cells in the Drosophila brain also express satiety-inducing cholecystokinin-like peptide, drosulfakinin","volume":"3","author":"S\u00f6derberg","year":"2012","journal-title":"Frontiers in Endocrinology"},{"key":"bib101","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.celrep.2014.08.060","type":"journal-article","article-title":"Control of lipid metabolism by tachykinin in Drosophila","volume":"9","author":"Song","year":"2014","journal-title":"Cell Reports"},{"key":"bib102","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.85041","type":"journal-article","article-title":"retro-Tango enables versatile retrograde circuit tracing in Drosophila","volume":"12","author":"Sorka\u00e7","year":"2023","journal-title":"eLife"},{"key":"bib103","doi-asserted-by":"publisher","first-page":"4397","DOI":"10.1016\/j.cub.2024.07.009","type":"journal-article","article-title":"Wind gates olfaction-driven search states in free flight","volume":"34","author":"Stupski","year":"2024","journal-title":"Current Biology"},{"key":"bib104","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.neuron.2012.08.035","type":"journal-article","article-title":"Peptide neuromodulation in invertebrate model systems","volume":"76","author":"Taghert","year":"2012","journal-title":"Neuron"},{"key":"bib105","doi-asserted-by":"publisher","first-page":"20697","DOI":"10.1073\/pnas.1218246109","type":"journal-article","article-title":"A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila","volume":"109","author":"Tayler","year":"2012","journal-title":"PNAS"},{"key":"bib106","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029897","type":"journal-article","article-title":"Mechanism and function of Drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor","volume":"7","author":"Terhzaz","year":"2012","journal-title":"PLOS ONE"},{"key":"bib107","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1073\/pnas.1501518112","type":"journal-article","article-title":"Insect capa neuropeptides impact desiccation and cold tolerance","volume":"112","author":"Terhzaz","year":"2015","journal-title":"PNAS"},{"key":"bib108","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.semcdb.2007.04.007","type":"journal-article","article-title":"The evolution of neurosecretory centers in bilaterian forebrains: Insights from protostomes","volume":"18","author":"Tessmar-Raible","year":"2007","journal-title":"Seminars in Cell & Developmental Biology"},{"key":"bib109","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10678","type":"journal-article","article-title":"Functional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila","volume":"7","author":"Thoma","year":"2016","journal-title":"Nature Communications"},{"key":"bib110","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/s0092-8674(00)00021-0","type":"journal-article","article-title":"An olfactory sensory map in the fly brain","volume":"102","author":"Vosshall","year":"2000","journal-title":"Cell"},{"key":"bib111","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.neuron.2020.08.017","type":"journal-article","article-title":"Visceral mechano-sensing neurons control Drosophila feeding by using piezo as a sensor","volume":"108","author":"Wang","year":"2020","journal-title":"Neuron"},{"key":"bib112","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1111\/j.1471-4159.2005.03634.x","type":"journal-article","article-title":"Direct mass spectrometric peptide profiling and fragmentation of larval peptide hormone release sites in Drosophila melanogaster reveals tagma-specific peptide expression and differential processing","volume":"96","author":"Wegener","year":"2006","journal-title":"Journal of Neurochemistry"},{"key":"bib113","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4","type":"book","volume-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"bib114","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.26349","type":"journal-article","article-title":"Synaptic and peptidergic connectome of a neurosecretory center in the annelid brain","volume":"6","author":"Williams","year":"2017","journal-title":"eLife"},{"key":"bib115","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.250528","type":"journal-article","article-title":"Corazonin mediates photoperiodically induced diapause in the bean bug Riptortus pedestris","volume":"228","author":"Xi","year":"2025","journal-title":"The Journal of Experimental Biology"},{"key":"bib116","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.57640","type":"journal-article","article-title":"Echinoderms provide missing link in the evolution of PrRP\/sNPF-type neuropeptide signalling","volume":"9","author":"Ya\u00f1ez-Guerra","year":"2020","journal-title":"eLife"},{"key":"bib117","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/s41422-018-0084-9","type":"journal-article","article-title":"A post-ingestive amino acid sensor promotes food consumption in Drosophila","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Research"},{"key":"bib118","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.neuron.2021.12.028","type":"journal-article","article-title":"Serotonergic neurons translate taste detection into internal nutrient regulation","volume":"110","author":"Yao","year":"2022","journal-title":"Neuron"},{"key":"bib119","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15693","type":"journal-article","article-title":"Regulation of starvation-induced hyperactivity by insulin and glucagon signaling in adult Drosophila","volume":"5","author":"Yu","year":"2016","journal-title":"eLife"},{"key":"bib120","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1007\/s00018-017-2682-y","type":"journal-article","article-title":"Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila","volume":"75","author":"Zandawala","year":"2018","journal-title":"Cellular and Molecular Life Sciences"},{"key":"bib121","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ygcen.2017.06.007","type":"journal-article","article-title":"The evolution and nomenclature of GnRH-type and corazonin-type neuropeptide signaling systems","volume":"264","author":"Zandawala","year":"2018","journal-title":"General and Comparative Endocrinology"},{"key":"bib122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007767","type":"journal-article","article-title":"Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin","volume":"14","author":"Zandawala","year":"2018","journal-title":"PLOS Genetics"},{"key":"bib123","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009425","type":"journal-article","article-title":"A neuroendocrine pathway modulating osmotic stress in Drosophila","volume":"17","author":"Zandawala","year":"2021","journal-title":"PLOS Genetics"},{"key":"bib124","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.cub.2020.01.045","type":"journal-article","article-title":"Spatial comparisons of mechanosensory information govern the grooming sequence in Drosophila","volume":"30","author":"Zhang","year":"2020","journal-title":"Current Biology"},{"key":"bib125","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl6121","type":"journal-article","article-title":"Nutrients and pheromones promote insulin release to inhibit courtship drive","volume":"8","author":"Zhang","year":"2022","journal-title":"Science Advances"},{"key":"bib126","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.109297","type":"journal-article","article-title":"Endogenous corazonin signaling modulates the post-mating switch in behavior and physiology in females of the brown planthopper and Drosophila","volume":"14","author":"Zhang","year":"2026","journal-title":"eLife"},{"key":"bib127","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00359-020-01399-6","type":"journal-article","article-title":"Evolution of olfactory circuits in insects","volume":"206","author":"Zhao","year":"2020","journal-title":"Journal of Comparative Physiology A"},{"key":"bib128","doi-asserted-by":"publisher","first-page":"3334","DOI":"10.1016\/j.cub.2022.06.031","type":"journal-article","article-title":"Structured sampling of olfactory input by the fly mushroom body","volume":"32","author":"Zheng","year":"2022","journal-title":"Current Biology"},{"key":"dataset1","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.20795210","type":"dataset","article-title":"McKim et al 2026: Synaptic connectome of a neurosecretory network in the Drosophila brain","volume-title":"Zenodo","author":"McKim","year":"2026","unstructured":"McKim T, Zandawala M. 2026. McKim et al 2026: Synaptic connectome of a neurosecretory network in the Drosophila brain. Zenodo."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/102684\/elife-102684-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/102684\/elife-102684-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/102684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:40:49Z","timestamp":1791819649000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/102684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":129,"alternative-id":["10.7554\/eLife.102684"],"URL":"https:\/\/doi.org\/10.7554\/elife.102684","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.08.28.609616","asserted-by":"subject"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.102684.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.102684.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.102684.2","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"doi","id":"10.5281\/zenodo.20795210","asserted-by":"subject"},{"id-type":"uri","id":"https:\/\/archive.softwareheritage.org\/swh:1:dir:b4351be98cde106f67c118ddabf510ae39a179b1;origin=https:\/\/github.com\/Zandawala-lab\/McKim-et-al-2026-Synaptic-connectome-of-a-neurosecretory-network-in-the-Drosophila-brain;visit=swh:1:snp:e7ca1ae3dec6aba46e9b6df4e121ac41e2ad70d9;anchor=swh:1:rev:c66280eb8f43ae5c2f772549c4a719bccd56950a","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP102684"}}