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While extensive research has focused on bacterial motility on surfaces and in porous media, chemotaxis in confined spaces remains poorly understood. Here, we investigate the chemotaxis of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    within microfluidic lanes under a linear concentration gradient of L-aspartate. We demonstrate that\n                    <jats:italic>E. coli<\/jats:italic>\n                    exhibits significantly enhanced chemotaxis in lanes with sidewalls compared to open surfaces. We attribute this phenomenon primarily to the intrinsic chiral clockwise circular motion of surface-swimming bacteria and the subsequent alignment effect upon collision with the sidewalls. By varying lane widths, we identify that an 8 \u03bcm width\u2014approximating the radius of bacterial circular swimming on surfaces\u2014maximizes chemotactic drift velocity. These results are supported by both experimental observations and stochastic simulations, establishing a clear proportional relationship between optimal lane width and the radius of bacterial circular swimming. Further geometric analysis provides an intuitive understanding of this phenomenon. Our results may offer insights into bacterial navigation in complex biological environments such as host tissues and biofilms, providing a preliminary step toward exploring microbial ecology in confined habitats and potential strategies for controlling bacterial infections.\n                  <\/jats:p>","DOI":"10.7554\/elife.102686","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T08:25:08Z","timestamp":1732177508000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.102686","source":"Crossref","is-referenced-by-count":1,"title":["Enhanced bacterial chemotaxis in confined microchannels occurs at lane widths matching circular swimming radius"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1664-9897","authenticated-orcid":true,"given":"Caijuan","family":"Yue","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04c4dkn09","id-type":"ROR","asserted-by":"publisher"}],"name":"Hefei National Research 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