{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:31:18Z","timestamp":1787567478786,"version":"build-2736575974"},"reference-count":41,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["21444781"],"award-info":[{"award-number":["21444781"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"award":["21444781"],"award-info":[{"award-number":["21444781"]}],"id":[{"id":"https:\/\/ror.org\/004rtk039","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP25H00994"],"award-info":[{"award-number":["JP25H00994"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"award":["JP25H00994"],"award-info":[{"award-number":["JP25H00994"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP25H01325"],"award-info":[{"award-number":["JP25H01325"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"award":["JP25H01325"],"award-info":[{"award-number":["JP25H01325"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP25K22454"],"award-info":[{"award-number":["JP25K22454"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"award":["JP25K22454"],"award-info":[{"award-number":["JP25K22454"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP22KJ2374"],"award-info":[{"award-number":["JP22KJ2374"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"award":["JP22KJ2374"],"award-info":[{"award-number":["JP22KJ2374"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP25K18465"],"award-info":[{"award-number":["JP25K18465"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"award":["JP25K18465"],"award-info":[{"award-number":["JP25K18465"]}],"id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"crossref","award":["10.52926\/JPMJFR204L"],"award-info":[{"award-number":["10.52926\/JPMJFR204L"],"id":[{"id":"10.52926\/jpmjfr204l","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"crossref"}]},{"award":["10.52926\/JPMJFR204L"],"award-info":[{"award-number":["10.52926\/JPMJFR204L"],"id":[{"id":"10.52926\/jpmjfr204l","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"https:\/\/ror.org\/00097mb19","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/02y123g31","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008664","name":"Ono Medical Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008664","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00krdxg91","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Invasive cancer is defined by the loss of epithelial cell traits resulting from the ectopic expression of epithelial\u2013mesenchymal transition (EMT)-related transcription factors such as Snail. Although EMT is known to impart chemoresistance to cancer cells, the precise molecular mechanisms remain elusive. We found that Snail expression confers chemoresistance by upregulating the cholesterol efflux pump ABCA1 as a countermeasure to the excess of cytotoxic free cholesterol relative to its major interaction partner in cellular membranes, sphingomyelin. This imbalance is introduced by the transcriptional repression of enzymes involved in the biosynthesis of sphingomyelin by Snail. Inhibiting esterification of cholesterol, which renders it inert, selectively suppresses growth of a xenograft model of Snail-positive kidney cancer. Our findings offer a new perspective on lipid-targeting strategies for invasive cancer therapy.<\/jats:p>","DOI":"10.7554\/elife.104374","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T09:25:09Z","timestamp":1734513909000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.104374","source":"Crossref","is-referenced-by-count":5,"title":["Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance"],"prefix":"10.7554","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3814-3299","authenticated-orcid":true,"given":"Atsushi","family":"Matsumoto","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00p4k0j84","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Kyushu University Graduate School of Medical Sciences","place":["Fukuoka, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6739-2948","authenticated-orcid":true,"given":"Akihito","family":"Inoko","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02h6cs343","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Aichi Medical University School of Medicine","place":["Nagakute, Japan"]},{"id":[{"id":"https:\/\/ror.org\/03kfmm080","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute","place":["Nagoya, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"given":"Takuya","family":"Tanaka","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dqf9946","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Chemical Science and Engineering, Institute of Science Tokyo, Meguro-ku","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Gen-Ichi","family":"Konishi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05dqf9946","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Chemical Science and Engineering, Institute of Science Tokyo, Meguro-ku","place":["Tokyo, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Waki","family":"Hosoda","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03kfmm080","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital","place":["Nagoya, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Takahiro","family":"Kojima","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03kfmm080","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Urology, Aichi Cancer Center Hospital","place":["Nagoya, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"given":"Koji","family":"Ohnishi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02h6cs343","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Pathology, Aichi Medical University School of Medicine","place":["Nagakute, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2936-3548","authenticated-orcid":true,"given":"Junichi","family":"Ikenouchi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00p4k0j84","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, Kyushu University Graduate School of Medical Sciences","place":["Fukuoka, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.devcel.2018.05.027","type":"journal-article","article-title":"EMT subtype influences epithelial plasticity and mode of cell migration","volume":"45","author":"Aiello","year":"2018","journal-title":"Developmental Cell"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01049","type":"journal-article","article-title":"Behind the wheel of epithelial plasticity in KRAS-Driven Cancers","volume":"9","author":"Arner","year":"2019","journal-title":"Frontiers in Oncology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/35000034","type":"journal-article","article-title":"The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells","volume":"2","author":"Batlle","year":"2000","journal-title":"Nature Cell Biology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/35000025","type":"journal-article","article-title":"The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression","volume":"2","author":"Cano","year":"2000","journal-title":"Nature Cell Biology"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02732-5","type":"journal-article","article-title":"Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance","volume":"9","author":"Cotte","year":"2018","journal-title":"Nature Communications"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.bbrc.2004.06.037","type":"journal-article","article-title":"Functional expression and characterization of the human ABCG1 and ABCG4 proteins: indications for heterodimerization","volume":"320","author":"Cserepes","year":"2004","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.7150\/jca.37890","type":"journal-article","article-title":"Antitumor functions and mechanisms of nitidine chloride in human cancers","volume":"11","author":"Cui","year":"2020","journal-title":"Journal of Cancer"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02882","type":"journal-article","article-title":"Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis","volume":"3","author":"Das","year":"2014","journal-title":"eLife"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.tips.2014.06.006","type":"journal-article","article-title":"Targeting EMT in cancer: opportunities for pharmacological intervention","volume":"35","author":"Davis","year":"2014","journal-title":"Trends in Pharmacological Sciences"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41586-023-05838-7","type":"journal-article","article-title":"RHOJ controls EMT-associated resistance to chemotherapy","volume":"616","author":"Debaugnies","year":"2023","journal-title":"Nature"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.fct.2014.01.049","type":"journal-article","article-title":"Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer","volume":"66","author":"Fang","year":"2014","journal-title":"Food and Chemical Toxicology"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nature15748","type":"journal-article","article-title":"Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance","volume":"527","author":"Fischer","year":"2015","journal-title":"Nature"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/nature14429","type":"journal-article","article-title":"Cell-intrinsic adaptation of lipid composition to local crowding drives social behaviour","volume":"523","author":"Frechin","year":"2015","journal-title":"Nature"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4757-z","type":"journal-article","article-title":"Association of tamoxifen resistance and lipid reprogramming in breast cancer","volume":"18","author":"Hultsch","year":"2018","journal-title":"BMC Cancer"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1210\/me.2013-1051","type":"journal-article","article-title":"Differential regulation of gene expression by LXRs in response to macrophage cholesterol loading","volume":"27","author":"Ignatova","year":"2013","journal-title":"Molecular Endocrinology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1242\/jcs.00389","type":"journal-article","article-title":"Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins\/occludin by Snail","volume":"116","author":"Ikenouchi","year":"2003","journal-title":"Journal of Cell Science"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"9525","DOI":"10.1074\/jbc.M111.327064","type":"journal-article","article-title":"Lipid polarity is maintained in absence of tight junctions","volume":"287","author":"Ikenouchi","year":"2012","journal-title":"The Journal of Biological Chemistry"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00280-010-1247-7","type":"journal-article","article-title":"Down-regulation of lipids transporter ABCA1 increases the cytotoxicity of nitidine","volume":"66","author":"Iwasaki","year":"2010","journal-title":"Cancer Chemotherapy and Pharmacology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"5113","DOI":"10.1091\/mbc.e07-04-0330","type":"journal-article","article-title":"Endocytic trafficking of sphingomyelin depends on its acyl chain length","volume":"18","author":"Koivusalo","year":"2007","journal-title":"Molecular Biology of the Cell"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/s41568-021-00332-6","type":"journal-article","article-title":"Linking EMT programmes to normal and neoplastic epithelial stem cells","volume":"21","author":"Lambert","year":"2021","journal-title":"Nature Reviews. Cancer"},{"key":"bib21","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/S0022-2275(20)32203-3","type":"journal-article","article-title":"Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines","volume":"39","author":"Lee","year":"1998","journal-title":"Journal of Lipid Research"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1002\/iub.319","type":"journal-article","article-title":"Mammalian ceramide synthases","volume":"62","author":"Levy","year":"2010","journal-title":"IUBMB Life"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1158\/1535-7163.MCT-17-1299","type":"journal-article","article-title":"Resistance to systemic therapies in clear cell renal cell carcinoma: mechanisms and management strategies","volume":"17","author":"Makhov","year":"2018","journal-title":"Molecular Cancer Therapeutics"},{"key":"bib24","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29363-9","type":"journal-article","article-title":"Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle","volume":"13","author":"McNally","year":"2022","journal-title":"Nature Communications"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cell.2016.06.028","type":"journal-article","article-title":"EMT: 2016","volume":"166","author":"Nieto","year":"2016","journal-title":"Cell"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/BF01215923","type":"journal-article","article-title":"Molecular and cellular features of esophageal cancer cells","volume":"119","author":"Nishihira","year":"1993","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/s41586-019-1526-3","type":"journal-article","article-title":"E-cadherin is required for metastasis in multiple models of breast cancer","volume":"573","author":"Padmanaban","year":"2019","journal-title":"Nature"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/s41586-018-0040-3","type":"journal-article","article-title":"Identification of the tumour transition states occurring during EMT","volume":"556","author":"Pastushenko","year":"2018","journal-title":"Nature"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cmet.2022.01.007","type":"journal-article","article-title":"The hallmarks of cancer metabolism: Still emerging","volume":"34","author":"Pavlova","year":"2022","journal-title":"Cell Metabolism"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.4062\/biomolther.2014.017","type":"journal-article","article-title":"Metabolism of very long-chain fatty acids: genes and pathophysiology","volume":"22","author":"Sassa","year":"2014","journal-title":"Biomolecules & Therapeutics"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.mce.2012.08.005","type":"journal-article","article-title":"Progestin modulates the lipid profile and sensitivity of breast cancer cells to docetaxel","volume":"363","author":"Schlaepfer","year":"2012","journal-title":"Molecular and Cellular Endocrinology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1083\/jcb.201711042","type":"journal-article","article-title":"Adherens junctions influence tight junction formation via changes in membrane lipid composition","volume":"217","author":"Shigetomi","year":"2018","journal-title":"The Journal of Cell Biology"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2217561120","type":"journal-article","article-title":"Cholesterol-rich domain formation mediated by ZO proteins is essential for tight junction formation","volume":"120","author":"Shigetomi","year":"2023","journal-title":"PNAS"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1016\/j.cmet.2021.09.001","type":"journal-article","article-title":"Cholesterol-induced toxicity: An integrated view of the role of cholesterol in multiple diseases","volume":"33","author":"Song","year":"2021","journal-title":"Cell Metabolism"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s12013-017-0792-7","type":"journal-article","article-title":"High cholesterol\/low cholesterol: effects in biological membranes: a review","volume":"75","author":"Subczynski","year":"2017","journal-title":"Cell Biochemistry and Biophysics"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s10863-020-09846-4","type":"journal-article","article-title":"Lipid composition of the cancer cell membrane","volume":"52","author":"Szlasa","year":"2020","journal-title":"Journal of Bioenergetics and Biomembranes"},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309721","type":"journal-article","article-title":"Fluorescent solvatochromic probes for long-term imaging of lipid order in living cells","volume":"11","author":"Tanaka","year":"2024","journal-title":"Advanced Science"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nrm2330","type":"journal-article","article-title":"Membrane lipids: where they are and how they behave","volume":"9","author":"van Meer","year":"2008","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"485","DOI":"10.20517\/cdr.2020.107","type":"journal-article","article-title":"ABCA1 is associated with the development of acquired chemotherapy resistance and predicts poor ovarian cancer outcome","volume":"4","author":"Wang","year":"2021","journal-title":"Cancer Drug Resistance"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s00467-010-1532-z","type":"journal-article","article-title":"Vitamin A deficiency results in dysregulation of lipid efflux pathway in rat kidney","volume":"25","author":"Yang","year":"2010","journal-title":"Pediatric Nephrology"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nature16064","type":"journal-article","article-title":"Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer","volume":"527","author":"Zheng","year":"2015","journal-title":"Nature"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/104374\/elife-104374-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/104374\/elife-104374-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/104374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:17:05Z","timestamp":1787563025000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/104374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":41,"alternative-id":["10.7554\/eLife.104374"],"URL":"https:\/\/doi.org\/10.7554\/elife.104374","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.10.22.619604","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2024.10.22.619604","asserted-by":"object"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.104374.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.104374.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.104374.2","asserted-by":"subject"}],"is-financed-by":[{"id-type":"doi","id":"10.52926\/JPMJFR204L","asserted-by":"subject"},{"id-type":"doi","id":"10.52926\/JPMJFR204L","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP104374"}}