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Arthritis is a major clinical manifestation of infection, and synovial tissue damage has been attributed to the excessive pro-inflammatory responses. The secretory leukocyte protease inhibitor (SLPI) promotes tissue repair and exerts anti-inflammatory effects. The role of SLPI in the development of Lyme arthritis in C57BL\/6 mice, which can be infected with\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    but only develop mild joint inflammation, was therefore examined.\n                    <jats:italic>Slpi<\/jats:italic>\n                    -deficient C57BL\/6 mice challenged with\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    had a higher infection load in the tibiotarsal joints and marked periarticular swelling compared to infected wild-type control mice. The ankle joint tissues of\n                    <jats:italic>B. burgdorferi-<\/jats:italic>\n                    infected\n                    <jats:italic>Slpi<\/jats:italic>\n                    -deficient mice contained significantly higher percentages of infiltrating neutrophils and macrophages.\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    -infected\n                    <jats:italic>Slpi<\/jats:italic>\n                    -deficient mice also exhibited elevated serum levels of IL-6, neutrophil elastase, and MMP-8. Moreover, using a recently developed BASEHIT (\n                    <jats:bold>BA<\/jats:bold>\n                    cterial\n                    <jats:bold>S<\/jats:bold>\n                    election to\n                    <jats:bold>E<\/jats:bold>\n                    lucidate\n                    <jats:bold>H<\/jats:bold>\n                    ost-microbe\n                    <jats:bold>I<\/jats:bold>\n                    nteractions in high\n                    <jats:bold>T<\/jats:bold>\n                    hroughput) library, we found that SLPI directly interacts with\n                    <jats:italic>B. burgdorferi<\/jats:italic>\n                    . These data demonstrate the importance of SLPI in suppressing periarticular joint inflammation in Lyme disease.\n                  <\/jats:p>","DOI":"10.7554\/elife.104913","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T11:25:41Z","timestamp":1737026741000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.104913","source":"Crossref","is-referenced-by-count":4,"title":["Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2396-2128","authenticated-orcid":true,"given":"Qian","family":"Yu","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03v76x132","id-type":"ROR","asserted-by":"publisher"}],"name":"Section of Infectious Diseases, Department of Internal Medicine, School of Medicine, Yale University","place":["New Haven, United 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