{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:31:38Z","timestamp":1787567498377,"version":"build-2736575974"},"reference-count":107,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["19K16292"],"award-info":[{"award-number":["19K16292"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21H02485"],"award-info":[{"award-number":["21H02485"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["10.52926\/jpmjcr1752"],"award-info":[{"award-number":["10.52926\/jpmjcr1752"],"id":[{"id":"10.52926\/jpmjcr1752","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["21bm0704060h0001"],"award-info":[{"award-number":["21bm0704060h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"award":["21bm0704060h0001"],"award-info":[{"award-number":["21bm0704060h0001"]}],"id":[{"id":"https:\/\/ror.org\/004rtk039","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["24bm1123049h0001"],"award-info":[{"award-number":["24bm1123049h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"award":["24bm1123049h0001"],"award-info":[{"award-number":["24bm1123049h0001"]}],"id":[{"id":"https:\/\/ror.org\/004rtk039","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["10.52926\/jpmjcr1921"],"award-info":[{"award-number":["10.52926\/jpmjcr1921"],"id":[{"id":"10.52926\/jpmjcr1921","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["21dm0207090h0003"],"award-info":[{"award-number":["21dm0207090h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"award":["21dm0207090h0003"],"award-info":[{"award-number":["21dm0207090h0003"]}],"id":[{"id":"https:\/\/ror.org\/004rtk039","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"crossref","award":["JP22zf0127007"],"award-info":[{"award-number":["JP22zf0127007"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"crossref"}]},{"award":["JP22zf0127007"],"award-info":[{"award-number":["JP22zf0127007"]}],"id":[{"id":"https:\/\/ror.org\/004rtk039","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Alzheimer\u2019s disease (AD), the leading cause of dementia, could potentially be mitigated through early detection and interventions. However, it remains challenging to assess subtle cognitive changes in the early AD continuum. Computational modeling is a promising approach to explain a generative process underlying subtle behavioral changes with a number of putative variables. Nonetheless, internal models of the patient remain underexplored in AD. Determining the states of an internal model between measurable pathological states and behavioral phenotypes would advance explanations about the generative process in earlier disease stages beyond assessing behavior alone. Previously, Gershman et al., 2017b proposed the latent cause model, which provides a normative account of memory modification phenomena in Pavlovian fear conditioning. Here, we assumed the latent cause model as an internal model and estimated internal states defined by the model parameters being in conjunction with measurable behavioral phenotypes. The 6- and 12-month-old\n                    <jats:italic>\n                      App\n                      <jats:sup>NL-G-F<\/jats:sup>\n                    <\/jats:italic>\n                    knock-in AD model mice and the age-matched control mice underwent memory modification learning, which consisted of classical fear conditioning, extinction, and reinstatement. The results showed that\n                    <jats:italic>\n                      App\n                      <jats:sup>NL-G-F<\/jats:sup>\n                    <\/jats:italic>\n                    mice exhibited a lower extent of reinstatement of fear memory. Computational modeling revealed that the deficit in the\n                    <jats:italic>\n                      App\n                      <jats:sup>NL-G-F<\/jats:sup>\n                    <\/jats:italic>\n                    mice would be due to their internal states being biased toward overgeneralization or overdifferentiation of their observations, and consequently, the competing memories were not retained. This deficit was replicated in another type of memory modification learning in the reversal Barnes maze task. Following reversal learning,\n                    <jats:italic>\n                      App\n                      <jats:sup>NL-G-F<\/jats:sup>\n                    <\/jats:italic>\n                    mice, given spatial cues, failed to infer coexisting memories for two goal locations during the trial. We concluded that the altered internal states of\n                    <jats:italic>\n                      App\n                      <jats:sup>NL-G-F<\/jats:sup>\n                    <\/jats:italic>\n                    mice illustrated their misclassification in the memory modification process. This novel approach highlights the potential of investigating internal states to precisely assess cognitive changes in early AD and multidimensionally evaluate how early interventions may work.\n                  <\/jats:p>","DOI":"10.7554\/elife.105347","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T03:50:36Z","timestamp":1743479436000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.105347","source":"Crossref","is-referenced-by-count":0,"title":["Misclassification in memory modification in AppNL-G-F knock-in mouse model of Alzheimer\u2019s disease"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3689-9749","authenticated-orcid":true,"given":"Mei-Lun","family":"Huang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kpeqv85","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Brain Development and Regeneration, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University","place":["Kyoto, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-4030","authenticated-orcid":true,"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kpeqv85","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Brain Development and Regeneration, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University","place":["Kyoto, Japan"]},{"id":[{"id":"https:\/\/ror.org\/02kpeqv85","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University","place":["Kyoto, Japan"]},{"id":[{"id":"https:\/\/ror.org\/02kpeqv85","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Deconstruction of Stem Cells, Institute for Life and Medical Sciences, Kyoto University","place":["Kyoto, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Hiroki","family":"Sasaguri","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04j1n1c04","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science","place":["Saitama, Japan"]},{"id":[{"id":"https:\/\/ror.org\/04j1n1c04","id-type":"ROR","asserted-by":"publisher"}],"name":"Dementia Pathophysiology Collaboration Unit, RIKEN Center for Brain Science","place":["Saitama, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Takashi","family":"Saito","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04wn7wc95","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neurocognitive Science, Institute of Brain Science, Graduate School of Medical Sciences, Nagoya City University","place":["Aichi, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Takaomi C","family":"Saido","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04j1n1c04","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science","place":["Saitama, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-481X","authenticated-orcid":true,"given":"Itaru","family":"Imayoshi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kpeqv85","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Brain Development and Regeneration, Division of Systemic Life Science, Graduate School of Biostudies, Kyoto University","place":["Kyoto, Japan"]},{"id":[{"id":"https:\/\/ror.org\/02kpeqv85","id-type":"ROR","asserted-by":"publisher"}],"name":"Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University","place":["Kyoto, Japan"]},{"id":[{"id":"https:\/\/ror.org\/02kpeqv85","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Deconstruction of Stem Cells, Institute for Life and Medical Sciences, Kyoto University","place":["Kyoto, Japan"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3233\/JAD-150855","type":"journal-article","article-title":"Spatial navigation in preclinical Alzheimer\u2019s disease","volume":"52","author":"Allison","year":"2016","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1002\/hipo.22162","type":"journal-article","article-title":"Pattern separation and pattern completion in Alzheimer\u2019s disease: evidence of rapid forgetting in amnestic mild cognitive impairment","volume":"23","author":"Ally","year":"2013","journal-title":"Hippocampus"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/ana.21509","type":"journal-article","article-title":"Prodromal Alzheimer\u2019s disease: Successive emergence of the clinical symptoms","volume":"64","author":"Amieva","year":"2008","journal-title":"Annals of Neurology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"5557","DOI":"10.1038\/s41380-021-01257-0","type":"journal-article","article-title":"Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the AppNL-G-F mouse model of Alzheimer\u2019s disease","volume":"26","author":"Arroyo-Garc\u00eda","year":"2021","journal-title":"Molecular Psychiatry"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1037\/h0077579","type":"journal-article","article-title":"Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat","volume":"93","author":"Barnes","year":"1979","journal-title":"Journal of Comparative and Physiological Psychology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/j.jalz.2014.12.007","type":"journal-article","article-title":"Alzheimer\u2019s disease first symptoms are age dependent: Evidence from the NACC dataset","volume":"11","author":"Barnes","year":"2015","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.cell.2015.07.015","type":"journal-article","article-title":"Circuit architecture of VTA dopamine neurons revealed by systematic input-output mapping","volume":"162","author":"Beier","year":"2015","journal-title":"Cell"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.3233\/JAD-230221","type":"journal-article","article-title":"Mnemonic discrimination performance in a memory clinic: a pilot study","volume":"94","author":"Belliart-Gu\u00e9rin","year":"2023","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","type":"journal-article","article-title":"ilastik: interactive machine learning for (bio)image analysis","volume":"16","author":"Berg","year":"2019","journal-title":"Nature Methods"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.14283\/jpad.2020.63","type":"journal-article","article-title":"The Alzheimer\u2019s disease neuroimaging initiative","volume":"8","author":"Bock","year":"2021","journal-title":"The Journal of Prevention of Alzheimer\u2019s Disease"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/WNN.0b013e318192ccf0","type":"journal-article","article-title":"Associative learning, acquired equivalence, and flexible generalization of knowledge in mild Alzheimer disease","volume":"22","author":"B\u00f3di","year":"2009","journal-title":"Cognitive and Behavioral Neurology"},{"key":"bib12","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-26113-1","type":"journal-article","article-title":"Impairment in novelty-promoted memory via behavioral tagging and capture before apparent memory loss in a knock-in model of Alzheimer\u2019s disease","volume":"12","author":"Broadbelt","year":"2022","journal-title":"Scientific Reports"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-642-27772-6_340-2","type":"book-chapter","article-title":"Behavioral flexibility: attentional shifting, rule switching, and response reversal","volume-title":"Encyclopedia of Psychopharmacology","author":"Brown","year":"2010"},{"key":"bib14","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2022.867053","type":"journal-article","article-title":"Anatomy and function of ventral tegmental area glutamate neurons","volume":"16","author":"Cai","year":"2022","journal-title":"Frontiers in Neural Circuits"},{"key":"bib15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007331","type":"journal-article","article-title":"A flexible and generalizable model of online latent-state learning","volume":"15","author":"Cochran","year":"2019","journal-title":"PLOS Computational Biology"},{"key":"bib16","type":"software","article-title":"OnlineLatentStateLearning","volume-title":"Github","author":"Cochran","year":"2019","unstructured":"Cochran AL, Cisler JM. 2019b. OnlineLatentStateLearning. Github. 986ccfc. https:\/\/github.com\/cochran4\/OnlineLatentStateLearning."},{"key":"bib17","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/s41582-018-0031-x","type":"journal-article","article-title":"Spatial navigation deficits - overlooked cognitive marker for preclinical Alzheimer disease?","volume":"14","author":"Coughlan","year":"2018","journal-title":"Nature Reviews. Neurology"},{"key":"bib18","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-023-00472-z","type":"journal-article","article-title":"Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer\u2019s disease mouse model","volume":"56","author":"Ding","year":"2023","journal-title":"Biological Research"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s13311-022-01185-z","type":"journal-article","article-title":"Heterogeneity in Alzheimer\u2019s disease diagnosis and progression rates: Implications for therapeutic trials","volume":"19","author":"Duara","year":"2022","journal-title":"Neurotherapeutics"},{"key":"bib20","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03169-3","type":"journal-article","article-title":"Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F\/NL-G-F mice","volume":"5","author":"Emre","year":"2022","journal-title":"Communications Biology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.schres.2020.11.048","type":"journal-article","article-title":"A generative framework for the study of delusions","volume":"245","author":"Erdmann","year":"2022","journal-title":"Schizophrenia Research"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/bf03193146","type":"journal-article","article-title":"G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behavior Research Methods"},{"key":"bib23","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0062","type":"journal-article","article-title":"A biased competition account of attention and memory in Alzheimer\u2019s disease","volume":"368","author":"Finke","year":"2013","journal-title":"Philosophical Transactions of the Royal Society B"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00210-018-1589-y","type":"journal-article","article-title":"Assessment of spatial learning and memory in the Barnes maze task in rodents-methodological consideration","volume":"392","author":"Gawel","year":"2019","journal-title":"Naunyn-Schmiedeberg\u2019s Archives of Pharmacology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1037\/a0017808","type":"journal-article","article-title":"Context, learning, and extinction","volume":"117","author":"Gershman","year":"2010","journal-title":"Psychological Review"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jmp.2011.08.004","type":"journal-article","article-title":"A tutorial on Bayesian nonparametric models","volume":"56","author":"Gershman","year":"2012","journal-title":"Journal of Mathematical Psychology"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3758\/s13420-015-0176-z","type":"journal-article","article-title":"Individual differences in learning predict the return of fear","volume":"43","author":"Gershman","year":"2015","journal-title":"Learning & Behavior"},{"key":"bib28","type":"software","article-title":"Memory modification model code","volume-title":"Github","author":"Gershman","year":"2017","unstructured":"Gershman SJ. 2017a. Memory modification model code. Github. e1164e1983d088bc628368d8f945aacf7b04d6ce. https:\/\/github.com\/sjgershm\/memory-modification."},{"key":"bib29","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23763","type":"journal-article","article-title":"The computational nature of memory modification","volume":"6","author":"Gershman","year":"2017","journal-title":"eLife"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.dadm.2017.12.004","type":"journal-article","article-title":"Temporal unfolding of declining episodic memory on the Free and Cued Selective Reminding Test in the predementia phase of Alzheimer\u2019s disease: Implications for clinical trials","volume":"10","author":"Grober","year":"2018","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2020.00037","type":"journal-article","article-title":"Nutil: A pre- and post-processing toolbox for histological rodent brain section images","volume":"14","author":"Groeneboom","year":"2020","journal-title":"Frontiers in Neuroinformatics"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15035-z","type":"journal-article","article-title":"Excitatory VTA to DH projections provide a valence signal to memory circuits","volume":"11","author":"Han","year":"2020","journal-title":"Nature Communications"},{"key":"bib33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10278-x","type":"journal-article","article-title":"Tau binding protein CAPON induces tau aggregation and neurodegeneration","volume":"10","author":"Hashimoto","year":"2019","journal-title":"Nature Communications"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"e816","DOI":"10.1016\/S2589-7500(22)00152-2","type":"journal-article","article-title":"The promise of a model-based psychiatry: building computational models of mental ill health","volume":"4","author":"Hauser","year":"2022","journal-title":"The Lancet. Digital Health"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.brat.2004.03.013","type":"journal-article","article-title":"Reinstatement of fear responses in human aversive conditioning","volume":"43","author":"Hermans","year":"2005","journal-title":"Behaviour Research and Therapy"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08274","type":"journal-article","article-title":"Prefrontal dopamine regulates fear reinstatement through the downregulation of extinction circuits","volume":"4","author":"Hitora-Imamura","year":"2015","journal-title":"eLife"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/nn.4238","type":"journal-article","article-title":"Computational psychiatry as a bridge from neuroscience to clinical applications","volume":"19","author":"Huys","year":"2016","journal-title":"Nature Neuroscience"},{"key":"bib38","doi-asserted-by":"publisher","DOI":"10.1016\/j.artmed.2023.102654","type":"journal-article","article-title":"Real-world prediction of preclinical Alzheimer\u2019s disease with a deep generative model","volume":"144","author":"Hwang","year":"2023","journal-title":"Artificial Intelligence in Medicine"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.neurobiolaging.2023.06.002","type":"journal-article","article-title":"Weak-hyperactive hippocampal CA1 neurons in the prodromal stage of Alzheimer\u2019s disease in hybrid AppNL-G-F\/NL-G-F \u00d7 Thy1-GCaMP6s+\/- mice suggest disrupted plasticity","volume":"130","author":"Inayat","year":"2023","journal-title":"Neurobiology of Aging"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","type":"journal-article","article-title":"NIA\u2010AA research framework: Toward a biological definition of Alzheimer\u2019s disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1002\/alz.13859","type":"journal-article","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"bib42","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0231-7","type":"journal-article","article-title":"Practical considerations for choosing a mouse model of Alzheimer\u2019s disease","volume":"12","author":"Jankowsky","year":"2017","journal-title":"Molecular Neurodegeneration"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.neuron.2020.06.023","type":"journal-article","article-title":"Disrupted place cell remapping and impaired grid cells in a Knockin model of Alzheimer\u2019s disease","volume":"107","author":"Jun","year":"2020","journal-title":"Neuron"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1002\/alz.12773","type":"journal-article","article-title":"Why a clinical trial is as good as its outcome measure: A framework for the selection and use of cognitive outcome measures for clinical trials of Alzheimer\u2019s disease","volume":"19","author":"Jutten","year":"2023","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"bib45","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/748212","type":"journal-article","article-title":"Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer\u2019s disease","volume":"2015","author":"Kirova","year":"2015","journal-title":"BioMed Research International"},{"key":"bib46","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00269-y","type":"journal-article","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nature Reviews. Disease Primers"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1146\/annurev-psych-032921-050951","type":"journal-article","article-title":"Memory and reward-based learning: A value-directed remembering perspective","volume":"73","author":"Knowlton","year":"2022","journal-title":"Annual Review of Psychology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1093\/brain\/awab254","type":"journal-article","article-title":"Evidence and implications of abnormal predictive coding in dementia","volume":"144","author":"Kocagoncu","year":"2021","journal-title":"Brain"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5692","type":"journal-article","article-title":"Examining the presence and nature of delusions in Alzheimer\u2019s disease and frontotemporal dementia syndromes","volume":"37","author":"Kumfor","year":"2022","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"bib50","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83851-4","type":"journal-article","article-title":"Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice","volume":"11","author":"Kundu","year":"2021","journal-title":"Scientific Reports"},{"key":"bib51","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.774600","type":"journal-article","article-title":"Spatial pattern separation testing differentiates alzheimer\u2019s disease biomarker-positive and biomarker-negative older adults with amnestic mild cognitive impairment","volume":"13","author":"Lacz\u00f3","year":"2021","journal-title":"Frontiers in Aging Neuroscience"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.bbr.2017.11.017","type":"journal-article","article-title":"Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition","volume":"364","author":"Latif-Hernandez","year":"2019","journal-title":"Behavioural Brain Research"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1101\/lm.048967.118","type":"journal-article","article-title":"Development of a mnemonic discrimination task using naturalistic stimuli with applications to aging and preclinical Alzheimer\u2019s disease","volume":"26","author":"Leal","year":"2019","journal-title":"Learning & Memory"},{"key":"bib54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmp.2020.102328","type":"journal-article","article-title":"An application of multinomial processing tree models and Bayesian methods to understanding memory impairment","volume":"95","author":"Lee","year":"2020","journal-title":"Journal of Mathematical Psychology"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"4201","DOI":"10.1016\/j.cub.2020.08.042","type":"journal-article","article-title":"Genetic Alzheimer\u2019s disease risk affects the neural mechanisms of pattern separation in hippocampal subfields","volume":"30","author":"Lee","year":"2020","journal-title":"Current Biology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s41237-023-00193-3","type":"journal-article","article-title":"Bayesian modeling of the mnemonic similarity task using multinomial processing trees","volume":"50","author":"Lee","year":"2023","journal-title":"Behaviormetrika"},{"key":"bib57","doi-asserted-by":"publisher","DOI":"10.3819\/ccbr.2009.40010","type":"journal-article","article-title":"Associative basis of landmark learning and integration in vertebrates","volume":"4","author":"Leising","year":"2009","journal-title":"Comparative Cognition & Behavior Reviews"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.conb.2020.10.012","type":"journal-article","article-title":"Dopamine, updated: reward prediction error and beyond","volume":"67","author":"Lerner","year":"2021","journal-title":"Current Opinion in Neurobiology"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.neuron.2005.05.002","type":"journal-article","article-title":"The hippocampal-VTA loop: controlling the entry of information into long-term memory","volume":"46","author":"Lisman","year":"2005","journal-title":"Neuron"},{"key":"bib60","type":"conference-paper","article-title":"Better transfer learning with inferred successor maps","author":"Madarasz","year":"2019","unstructured":"Madarasz T, Behrens T. 2019. Better transfer learning with inferred successor maps. 33rd Conference on Neural Information Processing Systems (NeurIPS 2019)."},{"key":"bib61","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.copsyc.2018.11.002","type":"journal-article","article-title":"Impairments of attention in Alzheimer\u2019s disease","volume":"29","author":"Malhotra","year":"2019","journal-title":"Current Opinion in Psychology"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nrn3492","type":"journal-article","article-title":"The contextual brain: implications for fear conditioning, extinction and psychopathology","volume":"14","author":"Maren","year":"2013","journal-title":"Nature Reviews. Neuroscience"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.nlm.2016.07.001","type":"journal-article","article-title":"Cognitive deficits in single App knock-in mouse models","volume":"135","author":"Masuda","year":"2016","journal-title":"Neurobiology of Learning and Memory"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.neurobiolaging.2018.10.026","type":"journal-article","article-title":"Age-dependent behavioral and biochemical characterization of single APP knock-in mouse (APPNL-G-F\/NL-G-F) model of Alzheimer\u2019s disease","volume":"75","author":"Mehla","year":"2019","journal-title":"Neurobiology of Aging"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1126\/science.1167975","type":"journal-article","article-title":"Extinction-reconsolidation boundaries: Key to persistent attenuation of fear memories","volume":"324","author":"Monfils","year":"2009","journal-title":"Science"},{"key":"bib66","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.tics.2011.11.018","type":"journal-article","article-title":"Computational psychiatry","volume":"16","author":"Montague","year":"2012","journal-title":"Trends in Cognitive Sciences"},{"key":"bib67","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101580","type":"journal-article","article-title":"Global and regional projections of the economic burden of Alzheimer\u2019s disease and related dementias from 2019 to 2050: A value of statistical life approach","volume":"51","author":"Nandi","year":"2022","journal-title":"EClinicalMedicine"},{"key":"bib68","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1056562461","type":"journal-article","article-title":"Slice sampling","volume":"31","author":"Neal","year":"2003","journal-title":"The Annals of Statistics"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.neuron.2013.11.017","type":"journal-article","article-title":"CA3 retrieves coherent representations from degraded input: direct evidence for CA3 pattern completion and dentate gyrus pattern separation","volume":"81","author":"Neunuebel","year":"2014","journal-title":"Neuron"},{"key":"bib70","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14727","type":"journal-article","article-title":"Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer\u2019s disease","volume":"8","author":"Nobili","year":"2017","journal-title":"Nature Communications"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.1017\/S0033291721000647","type":"journal-article","article-title":"Latent cause inference during extinction learning in trauma-exposed individuals with and without PTSD","volume":"52","author":"Norbury","year":"2022","journal-title":"Psychological Medicine"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1042\/BST0390902","type":"journal-article","article-title":"Hippocampal synaptic activity, pattern separation and episodic-like memory: implications for mouse models of Alzheimer\u2019s disease pathology","volume":"39","author":"Palmer","year":"2011","journal-title":"Biochemical Society Transactions"},{"key":"bib73","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3233\/JAD-200093","type":"journal-article","article-title":"Spatial pattern separation in early Alzheimer\u2019s disease","volume":"76","author":"Parizkova","year":"2020","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1080\/17470210902805589","type":"journal-article","article-title":"The 36th Sir Frederick Bartlett lecture: An associative analysis of spatial learning","volume":"62","author":"Pearce","year":"2009","journal-title":"Quarterly Journal of Experimental Psychology"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.neurobiolaging.2018.01.022","type":"journal-article","article-title":"Impairment of memory generalization in preclinical autosomal dominant Alzheimer\u2019s disease mutation carriers","volume":"65","author":"Petok","year":"2018","journal-title":"Neurobiology of Aging"},{"key":"bib76","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6216530","type":"journal-article","article-title":"Computational causal modeling of the dynamic biomarker cascade in Alzheimer\u2019s disease","volume":"2019","author":"Petrella","year":"2019","journal-title":"Computational and Mathematical Methods in Medicine"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jmp.2010.08.003","type":"journal-article","article-title":"Understanding memory impairment with memory models and hierarchical Bayesian analysis","volume":"55","author":"Pooley","year":"2011","journal-title":"Journal of Mathematical Psychology"},{"key":"bib78","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216796","type":"journal-article","article-title":"Spatial registration of serial microscopic brain images to three-dimensional reference atlases with the QuickNII tool","volume":"14","author":"Puchades","year":"2019","journal-title":"PLOS ONE"},{"key":"bib79","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/0023-9690(71)90002-6","type":"book-chapter","article-title":"A theory of pavlovian conditioning: variations in the effectiveness of reinforcement and nonreinforcement","volume-title":"Classical Conditioning II: Current Research and Theory","author":"Rescorla","year":"1972"},{"key":"bib80","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00690-6","type":"journal-article","article-title":"Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer\u2019s disease","volume":"13","author":"Saifullah","year":"2020","journal-title":"Molecular Brain"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nn.3697","type":"journal-article","article-title":"Single App knock-in mouse models of Alzheimer\u2019s disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nature Neuroscience"},{"key":"bib82","doi-asserted-by":"publisher","first-page":"12754","DOI":"10.1074\/jbc.RA119.009487","type":"journal-article","article-title":"Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation","volume":"294","author":"Saito","year":"2019","journal-title":"The Journal of Biological Chemistry"},{"key":"bib83","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-018-0446-8","type":"journal-article","article-title":"Cognitive and emotional alterations in App knock-in mouse models of A\u03b2 amyloidosis","volume":"19","author":"Sakakibara","year":"2018","journal-title":"BMC Neuroscience"},{"key":"bib84","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.51140","type":"journal-article","article-title":"Hippocampal remapping as hidden state inference","volume":"9","author":"Sanders","year":"2020","journal-title":"eLife"},{"key":"bib85","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.15252\/embj.201797397","type":"journal-article","article-title":"APP mouse models for Alzheimer\u2019s disease preclinical studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"The EMBO Journal"},{"key":"bib86","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1162\/neco.2007.19.6.1503","type":"journal-article","article-title":"A method for selecting the bin size of a time histogram","volume":"19","author":"Shimazaki","year":"2007","journal-title":"Neural Computation"},{"key":"bib87","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.jalz.2014.07.158","type":"journal-article","article-title":"Assessing cognition and function in Alzheimer\u2019s disease clinical trials: Do we have the right tools?","volume":"10","author":"Snyder","year":"2014","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"bib88","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1037\/a0037018","type":"journal-article","article-title":"Explaining compound generalization in associative and causal learning through rational principles of dimensional generalization","volume":"121","author":"Soto","year":"2014","journal-title":"Psychological Review"},{"key":"bib89","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","type":"journal-article","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: Recommendations from the National Institute on Aging\u2010Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"bib90","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.neuron.2014.10.038","type":"journal-article","article-title":"The evolution of preclinical Alzheimer\u2019s disease: Implications for prevention trials","volume":"84","author":"Sperling","year":"2014","journal-title":"Neuron"},{"key":"bib91","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1038\/s41380-024-02408-9","type":"journal-article","article-title":"Dopamine neuron degeneration in the Ventral Tegmental Area causes hippocampal hyperexcitability in experimental Alzheimer\u2019s Disease","volume":"29","author":"Spoleti","year":"2024","journal-title":"Molecular Psychiatry"},{"key":"bib92","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0108-24.2024","type":"journal-article","article-title":"Early-stage Alzheimer\u2019s disease affects fast but not slow adaptive processes in motor learning","volume":"11","author":"Sutter","year":"2024","journal-title":"eNeuro"},{"key":"bib93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180789","type":"journal-article","article-title":"Network analysis of exploratory behaviors of mice in a spatial learning and memory task","volume":"12","author":"Suzuki","year":"2017","journal-title":"PLOS ONE"},{"key":"bib94","type":"software","article-title":"BM_analysis","volume-title":"Github","author":"Suzuki","year":"2024","unstructured":"Suzuki Y. 2024a. BM_analysis. Github. 03a462d05bff272495393d1230b78b57a3892b15. https:\/\/github.com\/suzuki-yusuke\/BM_analysis.git."},{"key":"bib95","type":"software","article-title":"Comp_modeling_lcm","volume-title":"Github","author":"Suzuki","year":"2024","unstructured":"Suzuki Y. 2024b. Comp_modeling_lcm. Github. 3987ad55dd5386a8defdab57c56832c87066a0d6. https:\/\/github.com\/suzuki-yusuke\/comp_modeling_lcm.git."},{"key":"bib96","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0505-22.2023","type":"journal-article","article-title":"Scale space calibrates present and subsequent spatial learning in barnes maze in mice","volume":"10","author":"Tachiki","year":"2023","journal-title":"eNeuro"},{"key":"bib97","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14163","type":"journal-article","article-title":"Cognitive modeling of the mnemonic similarity task as a digital biomarker for Alzheimer\u2019s disease","volume":"1","author":"Vanderlip","year":"2024","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"bib98","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00088","type":"journal-article","article-title":"Using mice to model Alzheimer\u2019s dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models","volume":"5","author":"Webster","year":"2014","journal-title":"Frontiers in Genetics"},{"key":"bib99","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt250","type":"journal-article","article-title":"Performance on a pattern separation task by Alzheimer\u2019s patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E \u22084 status and cerebrospinal fluid amyloid-\u03b242 levels","volume":"6","author":"Wesnes","year":"2014","journal-title":"Alzheimer\u2019s Research & Therapy"},{"key":"bib100","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1007\/s00429-015-1075-y","type":"journal-article","article-title":"Impaired and preserved aspects of feedback learning in aMCI: Contributions of structural connectivity","volume":"221","author":"Wessa","year":"2016","journal-title":"Brain Structure & Function"},{"key":"bib101","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.bbr.2017.09.006","type":"journal-article","article-title":"Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer\u2019s disease","volume":"336","author":"Whyte","year":"2018","journal-title":"Behavioural Brain Research"},{"key":"bib102","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.tins.2006.10.002","type":"journal-article","article-title":"Neurocognitive aging: prior memories hinder new hippocampal encoding","volume":"29","author":"Wilson","year":"2006","journal-title":"Trends in Neurosciences"},{"key":"bib103","doi-asserted-by":"publisher","DOI":"10.1038\/s41540-023-00321-5","type":"journal-article","article-title":"Few-shot prediction of amyloid \u03b2 accumulation from mainly unpaired data on biomarker candidates","volume":"9","author":"Yada","year":"2023","journal-title":"NPJ Systems Biology and Applications"},{"key":"bib104","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.neuroimage.2010.03.040","type":"journal-article","article-title":"High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment","volume":"51","author":"Yassa","year":"2010","journal-title":"NeuroImage"},{"key":"bib105","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2019.00075","type":"journal-article","article-title":"QUINT: Workflow for quantification and spatial analysis of features in histological images from rodent brain","volume":"13","author":"Yates","year":"2019","journal-title":"Frontiers in Neuroinformatics"},{"key":"bib106","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-024-00712-0","type":"journal-article","article-title":"Updates on mouse models of Alzheimer\u2019s disease","volume":"19","author":"Zhong","year":"2024","journal-title":"Molecular Neurodegeneration"},{"key":"bib107","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01943-0","type":"journal-article","article-title":"Impairments of spatial memory in an Alzheimer\u2019s disease model via degeneration of hippocampal cholinergic synapses","volume":"8","author":"Zhu","year":"2017","journal-title":"Nature Communications"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/105347\/elife-105347-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/105347\/elife-105347-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/105347","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:18:56Z","timestamp":1787563136000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/105347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":107,"alternative-id":["10.7554\/eLife.105347"],"URL":"https:\/\/doi.org\/10.7554\/elife.105347","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.01.24.634705","asserted-by":"subject"},{"id-type":"doi","id":"10.1101\/2025.01.24.634705","asserted-by":"object"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.105347.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.105347.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.105347.2","asserted-by":"subject"}],"is-financed-by":[{"id-type":"doi","id":"10.52926\/jpmjcr1752","asserted-by":"subject"},{"id-type":"doi","id":"10.52926\/jpmjcr1921","asserted-by":"subject"},{"id-type":"doi","id":"10.52926\/JPMJCR1752","asserted-by":"object"},{"id-type":"doi","id":"10.52926\/JPMJCR1921","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP105347"}}