{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:29:43Z","timestamp":1787567383498,"version":"build-2736575974"},"reference-count":74,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    This study investigated the neural mechanisms involved in feelings of interpersonal guilt and responsibility evoked by social decisions in humans. In two studies (one during fMRI), participants repeatedly chose between safe and risky monetary outcomes in social contexts. Across conditions, each participant chose for both themselves and a partner (\n                    <jats:italic>Social<\/jats:italic>\n                    condition), or the partner chose for both themselves and the participant (\n                    <jats:italic>Partner<\/jats:italic>\n                    condition), or the participant chose just for themselves (\n                    <jats:italic>Solo<\/jats:italic>\n                    condition, control). If the risky option was chosen in the\n                    <jats:italic>Social<\/jats:italic>\n                    or\n                    <jats:italic>Partner<\/jats:italic>\n                    condition, participant and partner could each receive either the high or the low outcome of a lottery with 50% probability, independently of each other. Participants were shown the outcomes for themselves and for their partner on each trial and reported their momentary happiness every few trials. As expected, participant happiness decreased following both low lottery outcomes for themselves and for the partner. Crucially, happiness decreases following low outcomes for the partner were larger when the participant rather than their partner had made the choice, which fits an operational definition of guilt. This guilt effect was associated with BOLD signal increase in the left anterior insula. Connectivity between this region and the right inferior frontal gyrus varied depending on choice and experimental condition, suggesting that this part of prefrontal cortex is sensitive to guilt-related information during social choices. Variations in happiness were well explained by computational models based on participants\u2019 and partners\u2019 rewards and reward prediction errors. A model-based analysis revealed a left superior temporal sulcus cluster that tracked partner reward prediction errors that followed participant choices. Our findings identify neural mechanisms of guilt and social responsibility during social decisions under risk.\n                  <\/jats:p>","DOI":"10.7554\/elife.105391","type":"journal-article","created":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T10:31:05Z","timestamp":1742812265000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.105391","source":"Crossref","is-referenced-by-count":0,"title":["Contributions of insula and superior temporal sulcus to interpersonal guilt and responsibility in social decisions"],"prefix":"10.7554","volume":"14","author":[{"given":"Maria","family":"G\u00e4deke","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/041nas322","id-type":"ROR","asserted-by":"publisher"}],"name":"Masters in Neuroscience Program, University of Bonn","place":["Bonn, 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