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McDonald Fellowship","award":["566355-2022"],"award-info":[{"award-number":["566355-2022"]}]},{"name":"CIFAR Learning in Machine and Brains Fellowship"},{"name":"FRQNT Strategic Clusters Program"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Classical psychedelics induce complex visual hallucinations in humans, generating percepts that are coherent at a low level, but which have surreal, dream-like qualities at a high level. While there are many hypotheses as to how classical psychedelics could induce these effects, there are no concrete mechanistic models that capture the variety of observed effects in humans, while remaining consistent with the known pharmacological effects of classical psychedelics on neural circuits. In this work, we propose the \u2018oneirogen hypothesis,\u2019 which posits that the perceptual effects of classical psychedelics are a result of their pharmacological actions inducing neural activity states that truly are more similar to dream-like states. We simulate classical psychedelics\u2019 effects via manipulating neural network models trained on perceptual tasks with the Wake-Sleep algorithm. This established machine learning algorithm leverages two activity phases: a perceptual phase (wake) where sensory inputs are encoded, and a generative phase (dream) where the network internally generates activity consistent with stimulus-evoked responses. We simulate the action of psychedelics by partially shifting the model to the \u2018Sleep\u2019 state, which entails a greater influence of top-down connections, in line with the impact of psychedelics on apical dendrites. The effects resulting from this manipulation capture a number of experimentally observed phenomena, including the emergence of hallucinations, increases in stimulus-conditioned variability, and large increases in synaptic plasticity. We further provide a number of testable predictions which could be used to validate or invalidate our oneirogen hypothesis.<\/jats:p>","DOI":"10.7554\/elife.105968","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T12:30:57Z","timestamp":1749213057000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.105968","source":"Crossref","is-referenced-by-count":2,"title":["Modeling the hallucinatory effects of classical psychedelics in terms of replay-dependent plasticity mechanisms"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9749-9228","authenticated-orcid":true,"given":"Colin","family":"Bredenberg","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05c22rx21","id-type":"ROR","asserted-by":"publisher"}],"name":"Mila - Quebec AI Institute","place":["Montreal, Canada"]},{"id":[{"id":"https:\/\/ror.org\/0161xgx34","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Montreal","place":["Montreal, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Fabrice","family":"Normandin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05c22rx21","id-type":"ROR","asserted-by":"publisher"}],"name":"Mila - 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