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Understanding the dynamics controlling appetite requires deeply exploring the cell types and transitory states harbored in this brain site. We generated a multi-species DVC cell atlas using single-nuclei RNA-sequencing, by curating and harmonizing mouse and rat data, which includes &gt;180,000 cells and 123 cell identities at 5 granularities of cellular resolution. We report unique DVC features such as\n                    <jats:italic>Kcnj3<\/jats:italic>\n                    expression in Ca\n                    <jats:sup>+<\/jats:sup>\n                    -permeable astrocytes as well as new cell populations like neurons co-expressing\n                    <jats:italic>Th<\/jats:italic>\n                    and\n                    <jats:italic>Cck<\/jats:italic>\n                    , and a leptin receptor-expressing neuron population in the rat area postrema which is marked by expression of the progenitor marker,\n                    <jats:italic>Pdgfra<\/jats:italic>\n                    . In summary, our findings demonstrate a high degree of complexity within the DVC and provide a valuable tool for the study of this metabolic center.\n                  <\/jats:p>","DOI":"10.7554\/elife.106217","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T11:30:14Z","timestamp":1744630214000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.106217","source":"Crossref","is-referenced-by-count":7,"title":["A unified rodent atlas reveals the cellular complexity and evolutionary divergence of the dorsal vagal complex"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4828-3260","authenticated-orcid":true,"given":"Cecilia","family":"Hes","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04cpxjv19","id-type":"ROR","asserted-by":"publisher"}],"name":"Research Institute of the McGill University Health Centre, McGill University Health Centre","place":["Montreal, 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