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However, the mechanism driving such injury-induced MG cell-cycle re-entry remains incompletely understood. Combining single-cell transcriptomic analysis and in vivo clonal analysis, we identified previously undescribed\n                    <jats:italic>cxcl18b<\/jats:italic>\n                    -defined MG transitional states as essential routes toward MG proliferation following green\/red cone (G\/R cone) ablation. Inflammation blockage abolished the triggering of these transitional states, which expressed the gene modules shared by cells of the ciliary marginal zone (CMZ), where life-long adult neurogenesis takes place. Functional studies of the redox properties of these transitional states further demonstrated the regulatory role of nitric oxide (NO) produced by\n                    <jats:italic>Nos2b<\/jats:italic>\n                    in injury-induced MG proliferation. Finally, we developed a viral-based strategy to specifically disrupt\n                    <jats:italic>nos2b<\/jats:italic>\n                    in\n                    <jats:italic>cxcl18b<\/jats:italic>\n                    -defined MG transitional states and revealed the effect of transitional state-specific NO signaling. Our findings elucidate the precision redox mechanism underlying injury-induced MG cell-cycle re-entry, providing insights into species-specific mechanisms for vertebrate retina regeneration.\n                  <\/jats:p>","DOI":"10.7554\/elife.106274","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T19:15:16Z","timestamp":1746040516000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.106274","source":"Crossref","is-referenced-by-count":0,"title":["cxcl18b-defined transitional state-specific nitric oxide drives injury-induced M\u00fcller glia cell-cycle re-entry in the zebrafish retina"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4702-5914","authenticated-orcid":true,"given":"Aojun","family":"Ye","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/034t30j35","id-type":"ROR","asserted-by":"publisher"}],"name":"National Laboratory of Biomacromolecules, CAS Center for Excellence in 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