{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:28:09Z","timestamp":1787567289663,"version":"build-2736575974"},"reference-count":72,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["PJT-183843"],"award-info":[{"award-number":["PJT-183843"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"award":["PJT-183843"],"award-info":[{"award-number":["PJT-183843"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["PJT-479494"],"award-info":[{"award-number":["PJT-479494"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"award":["PJT-479494"],"award-info":[{"award-number":["PJT-479494"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004376","name":"Terry Fox Research Institute","doi-asserted-by":"crossref","award":["TFF-242122"],"award-info":[{"award-number":["TFF-242122"]}],"id":[{"id":"10.13039\/501100004376","id-type":"DOI","asserted-by":"crossref"}]},{"award":["TFF-242122"],"award-info":[{"award-number":["TFF-242122"]}],"id":[{"id":"https:\/\/ror.org\/00mtf6c40","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009326","name":"Cancer Research Society","doi-asserted-by":"crossref","award":["NGS"],"award-info":[{"award-number":["NGS"]}],"id":[{"id":"10.13039\/100009326","id-type":"DOI","asserted-by":"crossref"}]},{"award":["NGS"],"award-info":[{"award-number":["NGS"]}],"id":[{"id":"https:\/\/ror.org\/00t38a349","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"crossref","award":["Tier 1"],"award-info":[{"award-number":["Tier 1"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"crossref"}]},{"award":["Tier 1"],"award-info":[{"award-number":["Tier 1"]}],"id":[{"id":"https:\/\/ror.org\/0517h6h17","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MFE-171312"],"award-info":[{"award-number":["MFE-171312"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"award":["MFE-171312"],"award-info":[{"award-number":["MFE-171312"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"crossref","award":["22 2186"],"award-info":[{"award-number":["22 2186"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"crossref"}]},{"award":["22 2186"],"award-info":[{"award-number":["22 2186"]}],"id":[{"id":"https:\/\/ror.org\/0527jb766","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["2020-01665"],"award-info":[{"award-number":["2020-01665"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"award":["2020-01665"],"award-info":[{"award-number":["2020-01665"]}],"id":[{"id":"https:\/\/ror.org\/03zttf063","id-type":"ROR","asserted-by":"publisher"}]},{"name":"the Cancer Research Funds Radiumhemmet","award":["231263"],"award-info":[{"award-number":["231263"]}]},{"DOI":"10.13039\/501100003321","name":"Queen's University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003321","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Fonds de Recherche du Qu\u00e9bec \u2013 Sant\u00e9 (FRQS) Fellowships"},{"id":[{"id":"https:\/\/ror.org\/02eqrsj93","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Mitochondrial electron transport flavoprotein (ETF) insufficiency causes metabolic diseases known as a multiple acyl-CoA dehydrogenase deficiency (MADD). In contrast to muscle, ETFDH is a non-essential gene in acute lymphoblastic leukemia NALM6 cells, and its expression is reduced across human cancers. In various human cancer cell lines and mouse models, ETF insufficiency caused by decreased ETFDH expression limits flexibility of OXPHOS fuel utilisation but paradoxically increases bioenergetics and accelerates neoplastic growth via activation of the mTORC1\/BCL-6\/4E-BP1 axis. Collectively, these findings reveal that while ETF insufficiency is rare and has detrimental effects in non-malignant tissues, it is common in neoplasia, where ETFDH downregulation leads to bioenergetic and signaling reprogramming that accelerates neoplastic growth.<\/jats:p>","DOI":"10.7554\/elife.106587","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T10:31:16Z","timestamp":1746786676000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.106587","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1248-1839","authenticated-orcid":true,"given":"David","family":"Papadopoli","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Lady Davis Institute, SMBD JGH, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Gerald Bronfman Department of Oncology, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4265-243X","authenticated-orcid":true,"given":"Ranveer","family":"Palia","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Lady Davis Institute, SMBD JGH, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Medicine, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Predrag","family":"Jovanovic","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Lady Davis Institute, SMBD JGH, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Medicine, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"S\u00e9bastien","family":"Tabari\u00e8s","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Rosalind and Morris Goodman Cancer Institute, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Emma","family":"Ciccolini","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Lady Davis Institute, SMBD JGH, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Medicine, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Valerie","family":"Sabourin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Lady Davis Institute, SMBD JGH, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Sebastian","family":"Igelmann","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05f950310","id-type":"ROR","asserted-by":"publisher"}],"name":"VIB Center for Cancer Biology, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI)","place":["Leuven, Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Shannon","family":"McLaughlan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Lesley","family":"Zhan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"HaEun","family":"Kim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Medicine, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Nabila","family":"Chekkal","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Krzysztof J","family":"Szkop","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute","place":["Stockholm, Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5313-7057","authenticated-orcid":true,"given":"Thierry","family":"Bertomeu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0161xgx34","id-type":"ROR","asserted-by":"publisher"}],"name":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Jibin","family":"Zeng","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Lady Davis Institute, SMBD JGH, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1261-3638","authenticated-orcid":true,"given":"Julia","family":"Vassalakis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biomedical and Molecular Sciences, Queen's University","place":["Kingston, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Farzaneh","family":"Afzali","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biomedical and Molecular Sciences, Queen's University","place":["Kingston, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Slim","family":"Mzoughi","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0317dzj93","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of OncoGenomics and Innovative Therapeutics (COGIT), Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai","place":["New York, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"investigation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7764-5307","authenticated-orcid":true,"given":"Ernesto","family":"Guccione","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0317dzj93","id-type":"ROR","asserted-by":"publisher"}],"name":"Center of OncoGenomics and Innovative Therapeutics (COGIT), Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai","place":["New York, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Mike","family":"Tyers","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/057q4rt57","id-type":"ROR","asserted-by":"publisher"}],"name":"Program in Molecular Medicine, The Hospital for Sick Children","place":["Toronto, Canada"]},{"id":[{"id":"https:\/\/ror.org\/03dbr7087","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Genetics, University of Toronto","place":["Toronto, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Daina","family":"Avizonis","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Rosalind and Morris Goodman Cancer Institute, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Metabolomics Innovation Resource, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Ola","family":"Larsson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/056d84691","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institute","place":["Stockholm, Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8088-4197","authenticated-orcid":true,"given":"Lynne-Marie","family":"Postovit","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02y72wh86","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biomedical and Molecular Sciences, Queen's University","place":["Kingston, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-0822","authenticated-orcid":true,"given":"Sergej","family":"Djuranovic","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01yc7t268","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Cell Biology and Physiology, Washington University School of Medicine","place":["St. Louis, United States"]},{"id":[{"id":"https:\/\/ror.org\/05gq02987","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Molecular Biology, Cell Biology and Biochemistry, Brown University","place":["Providence, United States"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Josie","family":"Ursini-Siegel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Lady Davis Institute, SMBD JGH, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Gerald Bronfman Department of Oncology, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Medicine, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5568-6586","authenticated-orcid":true,"given":"Peter M","family":"Siegel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Medicine, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Rosalind and Morris Goodman Cancer Institute, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3047-0604","authenticated-orcid":true,"given":"Michael","family":"Pollak","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Lady Davis Institute, SMBD JGH, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Gerald Bronfman Department of Oncology, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Medicine, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5510-9762","authenticated-orcid":true,"given":"Ivan","family":"Topisirovic","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Gerald Bronfman Department of Oncology, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Medicine, McGill University","place":["Montr\u00e9al, Canada"]},{"id":[{"id":"https:\/\/ror.org\/01pxwe438","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Biochemistry, McGill University","place":["Montr\u00e9al, Canada"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","type":"journal-article","article-title":"Pan-cancer analysis of whole genomes","volume":"578","author":"Aaltonen","year":"2020","journal-title":"Nature"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"484","DOI":"10.3945\/jn.111.152595","type":"journal-article","article-title":"Isoleucine and leucine independently regulate mTOR signaling and protein synthesis in MAC-T cells and bovine mammary tissue slices","volume":"142","author":"Appuhamy","year":"2012","journal-title":"The Journal of Nutrition"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.1500154","type":"journal-article","article-title":"Translational control by lysine-encoding A-rich sequences","volume":"1","author":"Arthur","year":"2015","journal-title":"Science Advances"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.ccr.2004.05.024","type":"journal-article","article-title":"Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells","volume":"5","author":"Avdulov","year":"2004","journal-title":"Cancer Cell"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"6936","DOI":"10.1111\/febs.16164","type":"journal-article","article-title":"The mitochondrial coenzyme Q junction and complex III: biochemistry and pathophysiology","volume":"289","author":"Banerjee","year":"2022","journal-title":"The FEBS Journal"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00302-17","type":"journal-article","article-title":"A high-resolution genome-wide CRISPR\/Cas9 viability screen reveals structural features and contextual diversity of the human cell-essential proteome","volume":"38","author":"Bertomeu","year":"2018","journal-title":"Molecular and Cellular Biology"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.3791\/51998","type":"journal-article","article-title":"The soft agar colony formation assay","volume":"e51998","author":"Borowicz","year":"2014","journal-title":"Journal of Visualized Experiments"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1083\/jcb.201403009","type":"journal-article","article-title":"The general amino acid control pathway regulates mTOR and autophagy during serum\/glutamine starvation","volume":"206","author":"Chen","year":"2014","journal-title":"Journal of Cell Biology"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04103-9","type":"journal-article","article-title":"The activation of mTOR signalling modulates DNA methylation by enhancing DNMT1 translation in hepatocellular carcinoma","volume":"21","author":"Chen","year":"2023","journal-title":"Journal of Translational Medicine"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/onc.2009.358","type":"journal-article","article-title":"Q\u2019s next: the diverse functions of glutamine in metabolism, cell biology and cancer","volume":"29","author":"DeBerardinis","year":"2010","journal-title":"Oncogene"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1126\/science.1187532","type":"journal-article","article-title":"mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs","volume":"328","author":"Dowling","year":"2010","journal-title":"Science"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.pcl.2017.11.006","type":"journal-article","article-title":"Inborn errors of metabolism with myopathy: defects of fatty acid oxidation and the carnitine shuttle system","volume":"65","author":"El-Gharbawy","year":"2018","journal-title":"Pediatric Clinics of North America"},{"key":"bib13","doi-asserted-by":"publisher","DOI":"10.3791\/51455","type":"journal-article","article-title":"Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale","volume":"1","author":"Gandin","year":"2014","journal-title":"Journal of Visualized Experiments"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1046\/j.1432-1033.2003.03946.x","type":"journal-article","article-title":"Acyl-CoA dehydrogenases: A mechanistic overview","volume":"271","author":"Ghisla","year":"2004","journal-title":"European Journal of Biochemistry"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1101\/gad.13.11.1422","type":"journal-article","article-title":"Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism","volume":"13","author":"Gingras","year":"1999","journal-title":"Genes & Development"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1158\/1541-7786.MCR-20-0024","type":"journal-article","article-title":"Dual regulation of histone methylation by mTOR complexes controls glioblastoma tumor cell growth via EZH2 and SAM","volume":"18","author":"Harachi","year":"2020","journal-title":"Molecular Cancer Research"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/s1097-2765(00)00108-8","type":"journal-article","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Molecular Cell"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","type":"journal-article","article-title":"Oxidative Stress in Cancer","volume":"38","author":"Hayes","year":"2020","journal-title":"Cancer Cell"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.bbagen.2008.06.004","type":"journal-article","article-title":"Branched-chain amino acids and arginine suppress MaFbx\/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line","volume":"1780","author":"Herningtyas","year":"2008","journal-title":"Biochimica et Biophysica Acta"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s42255-023-00956-y","type":"journal-article","article-title":"An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis","volume":"6","author":"Herrero Mart\u00edn","year":"2024","journal-title":"Nature Metabolism"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.ccr.2010.01.021","type":"journal-article","article-title":"Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E","volume":"17","author":"Hsieh","year":"2010","journal-title":"Cancer Cell"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.cmet.2018.09.001","type":"journal-article","article-title":"Translational and HIF-1\u03b1-dependent metabolic reprogramming underpin metabolic plasticity and responses to kinase inhibitors and biguanides","volume":"28","author":"Hulea","year":"2018","journal-title":"Cell Metabolism"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.1016\/j.molcel.2021.08.028","type":"journal-article","article-title":"A hydride transfer complex reprograms NAD metabolism and bypasses senescence","volume":"81","author":"Igelmann","year":"2021","journal-title":"Molecular Cell"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1126\/science.1259472","type":"journal-article","article-title":"Metabolism: Differential regulation of mTORC1 by leucine and glutamine","volume":"347","author":"Jewell","year":"2015","journal-title":"Science"},{"key":"bib25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16352-z","type":"journal-article","article-title":"Translational control of breast cancer plasticity","volume":"11","author":"Jewer","year":"2020","journal-title":"Nature Communications"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/nrg816","type":"journal-article","article-title":"The fundamental role of epigenetic events in cancer","volume":"3","author":"Jones","year":"2002","journal-title":"Nature Reviews. Genetics"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","type":"journal-article","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109188","type":"journal-article","article-title":"MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of MTOR inhibitors","volume":"27","author":"Kim","year":"2024","journal-title":"iScience"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"W171","DOI":"10.1093\/nar\/gkz365","type":"journal-article","article-title":"CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing","volume":"47","author":"Labun","year":"2019","journal-title":"Nucleic Acids Research"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/s41589-021-00813-7","type":"journal-article","article-title":"Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth","volume":"17","author":"Lee","year":"2021","journal-title":"Nature Chemical Biology"},{"key":"bib31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-48386-y","type":"journal-article","article-title":"mTORC1 regulates cell survival under glucose starvation through 4EBP1\/2-mediated translational reprogramming of fatty acid metabolism","volume":"15","author":"Levy","year":"2024","journal-title":"Nature Communications"},{"key":"bib32","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69255","type":"journal-article","article-title":"The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress","volume":"11","author":"Liu","year":"2022","journal-title":"eLife"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"3327","DOI":"10.1074\/jbc.M310872200","type":"journal-article","article-title":"Activated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth","volume":"279","author":"Lynch","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.1038\/onc.2017.85","type":"journal-article","article-title":"Interferon \u03b3 is a STAT1-dependent direct inducer of BCL6 expression in imatinib-treated chronic myeloid leukemia cells","volume":"36","author":"Madapura","year":"2017","journal-title":"Oncogene"},{"key":"bib35","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3002-1-22","type":"journal-article","article-title":"PGC-1\u03b1 supports glutamine metabolism in breast cancer","volume":"1","author":"McGuirk","year":"2013","journal-title":"Cancer & Metabolism"},{"key":"bib36","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105899","type":"journal-article","article-title":"Disorders of flavin adenine dinucleotide metabolism: MADD and related deficiencies","volume":"132","author":"Mereis","year":"2021","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1080\/10409238.2021.1908952","type":"journal-article","article-title":"ETF dehydrogenase advances in molecular genetics and impact on treatment","volume":"56","author":"Missaglia","year":"2021","journal-title":"Critical Reviews in Biochemistry and Molecular Biology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"7189","DOI":"10.1074\/jbc.M116.774471","type":"journal-article","article-title":"Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements","volume":"292","author":"Mookerjee","year":"2017","journal-title":"The Journal of Biological Chemistry"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.cmet.2013.10.001","type":"journal-article","article-title":"mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation","volume":"18","author":"Morita","year":"2013","journal-title":"Cell Metabolism"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"473","DOI":"10.4161\/15384101.2014.991572","type":"journal-article","article-title":"mTOR coordinates protein synthesis, mitochondrial activity and proliferation","volume":"14","author":"Morita","year":"2015","journal-title":"Cell Cycle"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"4675","DOI":"10.1038\/onc.2015.515","type":"journal-article","article-title":"Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis","volume":"35","author":"Musa","year":"2016","journal-title":"Oncogene"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.4049\/jimmunol.1300675","type":"journal-article","article-title":"Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program","volume":"192","author":"Nakayamada","year":"2014","journal-title":"Journal of Immunology"},{"key":"bib43","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4128","type":"journal-article","article-title":"Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer","volume":"5","author":"Nilsson","year":"2014","journal-title":"Nature Communications"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1093\/brain\/awm135","type":"journal-article","article-title":"ETFDH mutations as a major cause of riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency","volume":"130","author":"Olsen","year":"2007","journal-title":"Brain"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.neo.2021.02.003","type":"journal-article","article-title":"Perturbations of cancer cell metabolism by the antidiabetic drug canagliflozin","volume":"23","author":"Papadopoli","year":"2021","journal-title":"Neoplasia"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ccr.2009.09.025","type":"journal-article","article-title":"p53-dependent translational control of senescence and transformation via 4E-BPs","volume":"16","author":"Petroulakis","year":"2009","journal-title":"Cancer Cell"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"24776","DOI":"10.1074\/jbc.M001938200","type":"journal-article","article-title":"Translational control of the antiapoptotic function of Ras","volume":"275","author":"Polunovsky","year":"2000","journal-title":"The Journal of Biological Chemistry"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.omtn.2021.10.005","type":"journal-article","article-title":"Gene dosage effects of poly(A) track-engineered hypomorphs","volume":"26","author":"Powell","year":"2021","journal-title":"Molecular Therapy. Nucleic Acids"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/s42255-024-00983-3","type":"journal-article","article-title":"Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis","volume":"6","author":"Ramachandran","year":"2024","journal-title":"Nature Metabolism"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.4049\/jimmunol.1701321","type":"journal-article","article-title":"B Cell-Intrinsic mTORC1 promotes germinal center-defining transcription factor gene expression, somatic hypermutation, and memory B cell generation in humoral immunity","volume":"200","author":"Raybuck","year":"2018","journal-title":"Journal of Immunology"},{"key":"bib51","first-page":"2415","type":"journal-article","article-title":"The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth","volume":"13","author":"Rousseau","year":"1996","journal-title":"Oncogene"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nmeth.3047","type":"journal-article","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nature Methods"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","type":"journal-article","article-title":"mTOR Signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1126\/science.1247005","type":"journal-article","article-title":"Genome-scale CRISPR-Cas9 knockout screening in human cells","volume":"343","author":"Shalem","year":"2014","journal-title":"Science"},{"key":"bib55","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10681-4","type":"journal-article","article-title":"An ErbB2\/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis","volume":"10","author":"Smith","year":"2019","journal-title":"Nature Communications"},{"key":"bib56","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02189-9","type":"journal-article","article-title":"Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern","volume":"4","author":"Tabari\u00e8s","year":"2021","journal-title":"Communications Biology"},{"key":"bib57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00369-y","type":"journal-article","article-title":"Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation","volume":"8","author":"Tan","year":"2017","journal-title":"Nature Communications"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1101\/gad.341505","type":"journal-article","article-title":"4E-BP functions as a metabolic brake used under stress conditions but not during normal growth","volume":"19","author":"Teleman","year":"2005","journal-title":"Genes & Development"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"8023","DOI":"10.1074\/jbc.M900301200","type":"journal-article","article-title":"An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1","volume":"284","author":"Thoreen","year":"2009","journal-title":"The Journal of Biological Chemistry"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1128\/MCB.01532-08","type":"journal-article","article-title":"Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer","volume":"29","author":"Topisirovic","year":"2009","journal-title":"Molecular and Cellular Biology"},{"key":"bib61","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23396-2","type":"journal-article","article-title":"STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer","volume":"12","author":"Totten","year":"2021","journal-title":"Nature Communications"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.cell.2017.06.010","type":"journal-article","article-title":"Defining a cancer dependency map","volume":"170","author":"Tsherniak","year":"2017","journal-title":"Cell"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1038\/emboj.2008.22","type":"journal-article","article-title":"ShcA signalling is essential for tumour progression in mouse models of human breast cancer","volume":"27","author":"Ursini-Siegel","year":"2008","journal-title":"The EMBO Journal"},{"key":"bib64","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41586-025-09428-7","type":"journal-article","article-title":"Structural basis for the dynamic regulation of mTORC1 by amino acids","volume":"646","author":"Valenstein","year":"2025","journal-title":"Nature"},{"key":"bib65","doi-asserted-by":"publisher","first-page":"D439","DOI":"10.1093\/nar\/gkab1061","type":"journal-article","article-title":"AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models","volume":"50","author":"Varadi","year":"2022","journal-title":"Nucleic Acids Research"},{"key":"bib66","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02243-3","type":"journal-article","article-title":"Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1","volume":"8","author":"Wang","year":"2017","journal-title":"Nature Communications"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.immuni.2017.08.011","type":"journal-article","article-title":"The kinase mTORC1 promotes the generation and suppressive function of follicular regulatory T cells","volume":"47","author":"Xu","year":"2017","journal-title":"Immunity"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cmet.2008.01.008","type":"journal-article","article-title":"ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress","volume":"7","author":"Yamaguchi","year":"2008","journal-title":"Cell Metabolism"},{"key":"bib69","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00348-3","type":"journal-article","article-title":"The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity","volume":"8","author":"Yi","year":"2017","journal-title":"Nature Communications"},{"key":"bib70","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2019.06.003","type":"journal-article","article-title":"An acyl-CoA dehydrogenase microplate activity assay using recombinant porcine electron transfer flavoprotein","volume":"581","author":"Zhang","year":"2019","journal-title":"Analytical Biochemistry"},{"key":"dataset1","doi-asserted-by":"publisher","DOI":"10.17632\/p4wxkr3vdm.1","type":"dataset","article-title":"Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics","volume-title":"Mendeley Data","author":"Papadopoli","year":"2026","unstructured":"Papadopoli D. 2026. Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics. Mendeley Data."},{"key":"dataset2","type":"dataset","article-title":"Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics","volume-title":"Metabolights","author":"Papadopoli","year":"2026","unstructured":"Papadopoli D. 2026. Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics. Metabolights. https:\/\/www.ebi.ac.uk\/metabolights\/MTBLS11048. MTBLS11048."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/106587\/elife-106587-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/106587\/elife-106587-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/106587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:01:45Z","timestamp":1787562105000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/106587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":72,"alternative-id":["10.7554\/eLife.106587"],"URL":"https:\/\/doi.org\/10.7554\/elife.106587","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.10.25.620155","asserted-by":"subject"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.106587.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.106587.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.106587.2","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"doi","id":"10.17632\/p4wxkr3vdm.1","asserted-by":"subject"},{"id-type":"accession","id":"MTBLS11048","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP106587"}}