{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:29:28Z","timestamp":1787567368729,"version":"build-2736575974"},"reference-count":50,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["PJT-183631"],"award-info":[{"award-number":["PJT-183631"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"award":["PJT-183631"],"award-info":[{"award-number":["PJT-183631"]}],"id":[{"id":"https:\/\/ror.org\/01gavpb45","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Cerebral small vessel disease (SVD) is a leading cause of stroke and dementia and yet is often an incidental finding in aged patients due to the inaccessibility of brain vasculature to imaging. Animal models are important for modelling the development and progression of SVD across the lifespan. In humans, reduced\n                    <jats:italic>FOXF2<\/jats:italic>\n                    is associated with an increased stroke risk and SVD prevalence in humans. In the zebrafish,\n                    <jats:italic>foxf2<\/jats:italic>\n                    is expressed in pericytes and vascular smooth muscle cells and is involved in vascular stability. We use partial\n                    <jats:italic>foxf2<\/jats:italic>\n                    loss of function (\n                    <jats:italic>foxf2a<\/jats:italic>\n                    <jats:sup>-\/-<\/jats:sup>\n                    ) to model the lifespan effect of reduced Foxf2 on small vessel biology. We find that the initial pool of pericytes in developing\n                    <jats:italic>foxf2a<\/jats:italic>\n                    mutants is strongly reduced. The few brain pericytes present in mutants have strikingly longer processes and enlarged soma.\n                    <jats:italic>foxf2a<\/jats:italic>\n                    mutant pericytes can partially repopulate the brain after ablation, suggesting some recovery is possible. Despite this capacity, adult\n                    <jats:italic>foxf2a<\/jats:italic>\n                    mutant brains show regional heterogeneity, with some areas of normality and others with severe pericyte depletion. Taken together,\n                    <jats:italic>foxf2a<\/jats:italic>\n                    mutants fail to generate a sufficient initial population of pericytes. The pericytes that remain have abnormal cell morphology. Over the lifespan, initial pericyte deficits are not repaired and lead to severely abnormal cerebrovasculature in adults. This work opens new avenues for modeling progressive genetic forms of human cerebral small vessel disease.\n                  <\/jats:p>","DOI":"10.7554\/elife.106720","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T10:30:38Z","timestamp":1747996238000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.106720","source":"Crossref","is-referenced-by-count":2,"title":["Progressive mural cell deficiencies across the lifespan in a foxf2 model of cerebral small vessel disease"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6861-5759","authenticated-orcid":true,"given":"Merry Faye E","family":"Graff","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00gmyvv50","id-type":"ROR","asserted-by":"publisher"}],"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary","place":["Calgary, 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