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Humoral immunity is essential for effective viral clearance; however, the glycosylation characteristics of immunoglobulin G (IgG) in HFRS patients are not well known. Peripheral blood mononuclear cells from HFRS patients were obtained for B subset analysis using scRNA-seq and flow cytometry. HTNV-specific IgG antibody titers were detected by enzyme-linked immunosorbent assay, and IgG glycosylation was analyzed by ultra-performance liquid chromatography. The proportions of the antibody-secreting memory (ASM) B cells and plasmablasts (PB) were significantly expanded among acute HFRS patients. We discovered significantly increased fucosylated IgG and decreased bisecting N-acetylglucosamine during the convalescent phase of HTNV infection. Meanwhile, positive correlations were observed between ASM subsets and galactosylation\/sialylation in the IgG Fc region, and between PB subsets and sialylation. Notably, the glycosylation-related genes, such as\n                    <jats:italic>RPN1 and RPN2<\/jats:italic>\n                    , were primarily expressed differentially in the ASM and PB subclusters, which were enriched in the N-glycosylation modifications of proteins through asparagine. Our findings indicated that IgG N-glycosylation may play a crucial role in combating HTNV infection and contributing to clinical recovery, which provided new insights for optimizing glycoengineered therapeutic antibodies.\n                  <\/jats:p>","DOI":"10.7554\/elife.106989","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T14:30:53Z","timestamp":1752244253000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.106989","source":"Crossref","is-referenced-by-count":1,"title":["Glycosylated IgG antibodies contribute to the recovery of haemorrhagic fever with renal syndrome patients"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9610-2567","authenticated-orcid":true,"given":"Chuansong","family":"Quan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05jb9pq57","id-type":"ROR","asserted-by":"publisher"}],"name":"Key Laboratory of Emerging Infectious Diseases in Universities of Shandong, 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