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An in silico model of affinity maturation in germinal centers (GCs) integrated with a model of differentiation and expansion of memory cells outside GCs during a recall response provides insight into the potential mechanisms underlying these results and shows how repeated exposure to the same immunogen can broaden the antibody response against diversified targets.<\/jats:p>","DOI":"10.7554\/elife.107042","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T09:15:06Z","timestamp":1756977306000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.107042","source":"Crossref","is-referenced-by-count":2,"title":["Repeated vaccination with homologous influenza hemagglutinin broadens human antibody responses to unmatched flu viruses"],"prefix":"10.7554","volume":"14","author":[{"given":"Yixiang","family":"Deng","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/053r20n13","id-type":"ROR","asserted-by":"publisher"}],"name":"Ragon Institute of 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