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T\n                    <jats:sub>RM<\/jats:sub>\n                    persistence requires autocrine TGF\u03b2 transactivated by integrins expressed on keratinocytes. T\n                    <jats:sub>RM<\/jats:sub>\n                    precursors that encounter antigen in the epidermis during development outcompete bystander T\n                    <jats:sub>RM<\/jats:sub>\n                    for TGF\u03b2 resulting in enhanced persistence. ScRNA-seq analysis of epidermal T\n                    <jats:sub>RM<\/jats:sub>\n                    revealed that local antigen experience in the skin resulted in an enhanced differentiation signature in comparison with bystanders. Upon recall, T\n                    <jats:sub>RM<\/jats:sub>\n                    displayed greater proliferation dictated by affinity of antigen experienced during epidermal development. Finally, local antigen experienced T\n                    <jats:sub>RM<\/jats:sub>\n                    differentially expressed TGF\u03b2RIII, which increases avidity of the TGF\u03b2RI\/II receptor complex for TGF\u03b2. Selective ablation of\n                    <jats:italic>Tgfbr3<\/jats:italic>\n                    reduced local antigen experienced T\n                    <jats:sub>RM<\/jats:sub>\n                    capacity to persist, rendering them phenotypically like bystander T\n                    <jats:sub>RM<\/jats:sub>\n                    . Thus, antigen-driven TCR signaling in the epidermis during T\n                    <jats:sub>RM<\/jats:sub>\n                    differentiation results in a lower TGF\u03b2 requirement for persistence and increased proliferative capacity that together enhance epidermal T\n                    <jats:sub>RM<\/jats:sub>\n                    fitness.\n                  <\/jats:p>","DOI":"10.7554\/elife.107096","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T11:30:36Z","timestamp":1751455836000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.107096","source":"Crossref","is-referenced-by-count":3,"title":["Epidermal resident memory T cell fitness requires antigen encounter in the skin"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2352-0036","authenticated-orcid":true,"given":"Eric 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