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Using\n                    <jats:italic>Xenopus tropicalis<\/jats:italic>\n                    tadpoles, we challenged the notion that glomerular activation is exclusively determined ipsilaterally. Glomerular responses evoked by unilateral stimulation were potentiated following transection of the contralateral olfactory nerve. The gain of function was observed as early as 2 hr after injury and faded away with a time constant of 4 days. Potentiation was mediated by the presence of larger and faster calcium transients driving glutamate release from OSN axon terminals. The cause was the reduction of the tonic presynaptic inhibition exerted by dopamine D\n                    <jats:sub>2<\/jats:sub>\n                    receptors. Inflammatory mediators generated by injury were not involved. These findings reveal the presence of a bilateral modulation of glomerular output driven by dopamine that compensates for imbalances in the number of operative OSNs present in the two olfactory epithelia. Considering that the constant turnover of OSNs is an evolutionarily conserved feature of the olfactory system and determines the innervation of glomeruli, the compensatory mechanism described here may represent a general property of the vertebrate olfactory system to establish an odor map.\n                  <\/jats:p>","DOI":"10.7554\/elife.107710","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:31:16Z","timestamp":1761060676000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.107710","source":"Crossref","is-referenced-by-count":0,"title":["Bilateral equalization of synaptic output in olfactory glomeruli of Xenopus tadpoles"],"prefix":"10.7554","volume":"14","author":[{"given":"Marta","family":"Casas","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/021018s57","id-type":"ROR","asserted-by":"publisher"}],"name":"Laboratory of Neurobiology, Department of Pathology and Experimental Therapy, Institute of Neurosciences, 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