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Here, we show that starvation induces a profound and progressive suppression of thermonociceptive behavior in\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    . During early food deprivation (1 hr without food), the thermoresponsive AWC sensory neurons mediate robust heat-evoked reversals over a broad range of stimulus intensities via glutamate and FLP-6 neuropeptide signaling, each covering distinct heat intensity ranges. After 6 hr of food deprivation (prolonged starvation), heat-evoked reversal responses are nearly abolished, independently of external food odor cues. Starvation shifts the distribution of AWC heat-evoked calcium response polarity, from mostly excitatory responses to a heterogeneous pattern combining excitatory and inhibitory activities. This switch relies on ASI neurons, proposed to sense internal state. INS-32 and NLP-18 neuropeptide signals from ASI switch from reversal-promoting to reversal-inhibiting effects. In addition, reversal-promoting glutamatergic transmission by AWC is antagonized by glutamatergic transmission from non-AWC neurons that suppress FLP-6-dependent reversals. Our findings define a circuit logic by which gating of nociceptive responsiveness by internal nutritional state is linked to dynamic modulation of sensory neuron activity patterns and orchestrated by bidirectional glutamatergic and neuropeptidergic signals.\n                  <\/jats:p>","DOI":"10.7554\/elife.108246","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T15:30:10Z","timestamp":1758727810000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.108246","source":"Crossref","is-referenced-by-count":0,"title":["Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic 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