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Here we report that polyQ ATXN1 oligomers can propagate locally in vivo in mice predisposed to SCA1 following intracerebral oligomeric tissue inoculation. Our data also show that targeting these oligomers with passive immunotherapy leads to some improvement in motor coordination in SCA1 mice and to a modest increase in their life span. These findings provide evidence that oligomer propagation is regionally limited in SCA1 and that immunotherapy targeting extracellular oligomers can mildly modify disease phenotypes.<\/jats:p>","DOI":"10.7554\/elife.10891","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T09:00:47Z","timestamp":1450342847000},"source":"Crossref","is-referenced-by-count":19,"title":["Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes"],"prefix":"10.7554","volume":"4","author":[{"given":"Cristian A","family":"Lasagna-Reeves","sequence":"first","affiliation":[{"name":"Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, United States"},{"name":"Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime 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