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Using\n                    <jats:italic>Drosophila<\/jats:italic>\n                    ovaries as a model system, here we discovered that\n                    <jats:italic>bam<\/jats:italic>\n                    or\n                    <jats:italic>bgcn<\/jats:italic>\n                    mutant germline tumors inhibit the differentiation of neighboring wild-type germline stem cells (GSCs). Mechanistically, these tumor cells mimic the stem cell niche by secreting the bone morphogenetic protein (BMP) ligands Dpp and Gbb, but at reduced levels, resulting in moderate BMP signaling activation in adjacent GSCs. Such BMP signaling activation is sufficient to repress\n                    <jats:italic>bam<\/jats:italic>\n                    transcription, thereby blocking GSC differentiation. To our knowledge, this is the first example that tumors can functionally mimic a stem cell niche to inhibit the differentiation of neighboring wild-type stem cells. Similar regulatory paradigms may operate in mammalian tissues, including humans, during tumorigenesis.\n                  <\/jats:p>","DOI":"10.7554\/elife.108910","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:30:15Z","timestamp":1761579015000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.108910","source":"Crossref","is-referenced-by-count":0,"title":["Tumors mimic the niche to inhibit neighboring stem cell differentiation"],"prefix":"10.7554","volume":"14","author":[{"given":"Yang","family":"Zhang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01y1kjr75","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics and Cell Biology, College of Life Sciences, Nankai University","place":["Tianjin, 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