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Phosphorylation of I\u03baB proteins by IKK results in their degradation and consequent activation of NF-\u03baB transcription factors. RIPK1, a critical cell death regulator, is also a direct target of IKK kinase activity, thereby repressing its cell death activity. In \u03b1\u03b2 T cells, the RIPK1 kinase activity of IKK is critical for normal thymic development while mature \u03b1\u03b2 T cells require IKK for both activation of NF-\u03baB dependent survival programmes and repression of RIPK1. \u03b3\u03b4 T cells play a unique and versatile role in host immunity with specific effector functions that enable them to act as early responders in immune defence. The role of IKK-regulated pathways in their development and survival is not known. Here, we dissect the function of IKK and downstream pathways for normal \u03b3\u03b4 T cell homeostasis. We find that IKK is critical to establish replete \u03b3\u03b4 T cell populations, but that mechanism varys between different subsets. Type 1 \u03b3\u03b4 T cells require IKK-dependent NF-\u03baB activation for their generation, while IKK is redundant for development of adaptive \u03b3\u03b4 T cells. Instead, IKK-dependent NF-\u03baB activation is required for their long-term survival. We also find evidence that IKK repression of RIPK1 is required for survival of peripheral but not thymic \u03b3\u03b4 T cells. Ablation of CASPASE8 did not rescue \u03b3\u03b4 T cells in the absence of IKK but rather revealed a potent sensitivity of all \u03b3\u03b4 subsets to necroptosis, which was rescued by kinase-dead RIPK1. Overall, we reveal critical requirements for IKK-regulated inflammatory pathways by \u03b3\u03b4 T cells that contrast with those of \u03b1\u03b2 T cells, and between different subsets, highlighting the complexity of the regulation of these pathways in the adaptive immune system.<\/jats:p>","DOI":"10.7554\/elife.108940","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:30:22Z","timestamp":1762957822000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.108940","source":"Crossref","is-referenced-by-count":0,"title":["Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive \u03b3\u03b4 T 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