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Neuronal information processing in the hippocampus can be regulated by many types of neuropeptides. Cholecystokinin (\n                    <jats:italic>Cck<\/jats:italic>\n                    ), the most abundant neuropeptide in the central nervous system that is involved in modulating neuronal functions, such as cognition, memory, and neuroplasticity, is widely expressed in the hippocampus. However, whether local excitatory\n                    <jats:italic>Cck<\/jats:italic>\n                    neurons modulate hippocampal function is still unclear. In this study, we showed that CA1 pyramidal neurons receive projections from excitatory Cck neurons in area CA3 (CA3\n                    <jats:italic>\n                      <jats:sup>Cck<\/jats:sup>\n                    <\/jats:italic>\n                    neurons) in adult mice. Subsequently, activation of the CA1-projecting CA3\n                    <jats:italic>\n                      <jats:sup>Cck<\/jats:sup>\n                    <\/jats:italic>\n                    neurons triggers the release of\n                    <jats:italic>Cck<\/jats:italic>\n                    . Then, we found that the activity of CA3\n                    <jats:italic>\n                      <jats:sup>Cck<\/jats:sup>\n                    <\/jats:italic>\n                    -CA1 neurons supports the hippocampal-dependent tasks. Furthermore, inhibition of CA3\n                    <jats:italic>\n                      <jats:sup>Cck<\/jats:sup>\n                    <\/jats:italic>\n                    -CA1 projections or knockdown of CA3\n                    <jats:italic>\n                      <jats:sup>Cck<\/jats:sup>\n                    <\/jats:italic>\n                    gene expression markedly impaired the behavioral tasks and neuroplasticity. Taken together, these results may add to a better understanding of how neuromodulators regulate the neural functions in the central nervous system.\n                  <\/jats:p>","DOI":"10.7554\/elife.109001","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T14:30:25Z","timestamp":1763044225000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.109001","source":"Crossref","is-referenced-by-count":0,"title":["Excitatory cholecystokinin neurons in the CA3 area regulate the navigation learning and neuroplasticity"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3188-6559","authenticated-orcid":true,"given":"Fengwen","family":"Huang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03q8dnn23","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Neuroscience, City University of Hong Kong","place":["Hong Kong, 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