{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:29:28Z","timestamp":1787567368556,"version":"build-2736575974"},"reference-count":84,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["10.35802\/206330"],"award-info":[{"award-number":["10.35802\/206330"],"id":[{"id":"10.35802\/206330","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"award":["10.35802\/206330"],"award-info":[{"award-number":["10.35802\/206330"],"id":[{"id":"10.35802\/206330","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["10.35802\/226645"],"award-info":[{"award-number":["10.35802\/226645"],"id":[{"id":"10.35802\/226645","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"award":["10.35802\/226645"],"award-info":[{"award-number":["10.35802\/226645"],"id":[{"id":"10.35802\/226645","id-type":"DOI","asserted-by":"publisher"}]}],"id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Medical Research Council","award":["MR\/P00878\/X"],"award-info":[{"award-number":["MR\/P00878\/X"]}]},{"award":["MR\/P00878\/X"],"award-info":[{"award-number":["MR\/P00878\/X"]}],"id":[{"id":"https:\/\/ror.org\/03x94j517","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"crossref","award":["ACF-2023-13-013"],"award-info":[{"award-number":["ACF-2023-13-013"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"award":["ACF-2023-13-013"],"award-info":[{"award-number":["ACF-2023-13-013"]}],"id":[{"id":"https:\/\/ror.org\/0187kwz08","id-type":"ROR","asserted-by":"publisher"}]},{"name":"NIHR Oxford Health BRC"},{"id":[{"id":"https:\/\/ror.org\/00aps1a34","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/00aps1a34","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The brain continuously integrates rapidly changing visual input across eye movements to maintain stable perception, yet the precise mechanisms underpinning dynamic working memory and how these break down in brain diseases remain unclear. We developed a novel eye-tracking paradigm and computational models to investigate how spatial and colour information are updated across saccades in the human brain. Our findings reveal that saccades selectively impair spatial but not colour memory. Computational modelling identified that spatial representations are maintained in a dual eye-centred frame of reference which is actively updated by a noisy memory of saccades but is vulnerable to interference. Using this model, we found that specific mechanistic failures in initial encoding and memory decay, rather than the saccadic updating process itself, account for spatial working memory deficits in Alzheimer\u2019s and Parkinson\u2019s disease. These results provide a mechanistic understanding of how dynamic spatial memory operates in health and its disruption in neurodegenerative disorders.<\/jats:p>","DOI":"10.7554\/elife.109581","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:30:15Z","timestamp":1767191415000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.109581","source":"Crossref","is-referenced-by-count":0,"title":["Transsaccadic working memory in healthy ageing and neurodegenerative disease"],"prefix":"10.7554","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-0702","authenticated-orcid":true,"given":"Sijia","family":"Zhao","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Psychology, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"corresponding-author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5108-5743","authenticated-orcid":true,"given":"Thomas","family":"Parr","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Nuffield Department of Clinical Neurosciences, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Rob","family":"Udale","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Psychology, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"software","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1901-2485","authenticated-orcid":true,"given":"Verena","family":"Klar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Psychology, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"given":"Gabriel","family":"Davis Jones","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Nuffield Department of Clinical Neurosciences, University of Oxford","place":["Oxford, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Nuffield Department of Women\u2019s and Reproductive Health, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"software","vocabulary":"credit"}]},{"given":"Anna","family":"Scholcz","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Psychology, University of Oxford","place":["Oxford, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Nuffield Department of Clinical Neurosciences, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"given":"Sofia","family":"Toniolo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Nuffield Department of Clinical Neurosciences, University of Oxford","place":["Oxford, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/0080acb59","id-type":"ROR","asserted-by":"publisher"}],"name":"Cognitive Disorders Clinic, John Radcliffe Hospital, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0735-4349","authenticated-orcid":true,"given":"Sanjay G","family":"Manohar","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Psychology, University of Oxford","place":["Oxford, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Nuffield Department of Clinical Neurosciences, University of Oxford","place":["Oxford, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/0080acb59","id-type":"ROR","asserted-by":"publisher"}],"name":"Cognitive Disorders Clinic, John Radcliffe Hospital, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Masud","family":"Husain","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Experimental Psychology, University of Oxford","place":["Oxford, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"Nuffield Department of Clinical Neurosciences, University of Oxford","place":["Oxford, United Kingdom"]},{"id":[{"id":"https:\/\/ror.org\/0080acb59","id-type":"ROR","asserted-by":"publisher"}],"name":"Cognitive Disorders Clinic, John Radcliffe Hospital, University of Oxford","place":["Oxford, United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"},{"role":"conceptualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"4374","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.717002","type":"journal-article","article-title":"The visuospatial and sensorimotor functions of posterior parietal cortex in drawing tasks: a review","volume":"13","author":"Bai","year":"2021","journal-title":"Frontiers in Aging Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1162\/jocn.1995.7.1.66","type":"journal-article","article-title":"Memory representations in natural tasks","volume":"7","author":"Ballard","year":"1995","journal-title":"Journal of Cognitive Neuroscience"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"4525","DOI":"10.1523\/JNEUROSCI.0300-20.2020","type":"journal-article","article-title":"Parietal cortex integrates saccade and object orientation signals to update grasp plans","volume":"40","author":"Baltaretu","year":"2020","journal-title":"The Journal of Neuroscience"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1097\/WNR.0b013e328244e6c3","type":"journal-article","article-title":"Spatial remapping of the visual world across saccades","volume":"18","author":"Bays","year":"2007","journal-title":"Neuroreport"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1080\/00273171.2010.498292","type":"journal-article","article-title":"Assessing mediational models: testing and interval estimation for indirect effects","volume":"45","author":"Biesanz","year":"2010","journal-title":"Multivariate Behavioral Research"},{"key":"bib6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1163\/156856897X00357","type":"journal-article","article-title":"The psychophysics toolbox","volume":"10","author":"Brainard","year":"1997","journal-title":"Spatial Vision"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14640748108400762","type":"journal-article","article-title":"Recency effects in visual memory","volume":"33","author":"Broadbent","year":"1981","journal-title":"The Quarterly Journal of Experimental Psychology Section A"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.tics.2010.01.007","type":"journal-article","article-title":"Visual stability based on remapping of attention pointers","volume":"14","author":"Cavanagh","year":"2010","journal-title":"Trends in Cognitive Sciences"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1038\/nrn873","type":"journal-article","article-title":"A common reference frame for movement plans in the posterior parietal cortex","volume":"3","author":"Cohen","year":"2002","journal-title":"Nature Reviews. Neuroscience"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"997","DOI":"10.3758\/BF03193626","type":"journal-article","article-title":"Look little, look often: the influence of gaze frequency on drawing accuracy","volume":"67","author":"Cohen","year":"2005","journal-title":"Perception & Psychophysics"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1177\/0031512521990358","type":"journal-article","article-title":"Assessing the development of fine motor control in elementary school children using drawing and tracing tasks","volume":"128","author":"Cohen","year":"2021","journal-title":"Perceptual and Motor Skills"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1146\/annurev.neuro.22.1.319","type":"journal-article","article-title":"Space and attention in parietal cortex","volume":"22","author":"Colby","year":"1999","journal-title":"Annual Review of Neuroscience"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1002\/gps.1094","type":"journal-article","article-title":"Pentagon drawing and neuropsychological performance in Dementia with Lewy Bodies, Alzheimer\u2019s disease, Parkinson\u2019s disease and Parkinson\u2019s disease with dementia","volume":"19","author":"Cormack","year":"2004","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1152\/jn.00117.2004","type":"journal-article","article-title":"Spatial transformations for eye-hand coordination","volume":"92","author":"Crawford","year":"2004","journal-title":"Journal of Neurophysiology"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.cub.2020.11.013","type":"journal-article","article-title":"When natural behavior engages working memory","volume":"31","author":"Draschkow","year":"2021","journal-title":"Current Biology"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1037\/0096-1523.33.6.1352","type":"journal-article","article-title":"Trade-offs between gaze and working memory use","volume":"33","author":"Droll","year":"2007","journal-title":"Journal of Experimental Psychology. Human Perception and Performance"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1126\/science.1553535","type":"journal-article","article-title":"The updating of the representation of visual space in parietal cortex by intended eye movements","volume":"255","author":"Duhamel","year":"1992","journal-title":"Science"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/j.0956-7976.2004.00697.x","type":"journal-article","article-title":"Microsaccades keep the eyes\u2019 balance during fixation","volume":"15","author":"Engbert","year":"2004","journal-title":"Psychological Science"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"9476","DOI":"10.1523\/JNEUROSCI.1169-20.2020","type":"journal-article","article-title":"Low-level visual information is maintained across saccades, allowing for a postsaccadic handoff between visual areas","volume":"40","author":"Fabius","year":"2020","journal-title":"The Journal of Neuroscience"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.neuroimage.2015.11.015","type":"journal-article","article-title":"Bayesian model reduction and empirical Bayes for group (DCM) studies","volume":"128","author":"Friston","year":"2016","journal-title":"NeuroImage"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1073\/pnas.1113168109","type":"journal-article","article-title":"Retinotopic memory is more precise than spatiotopic memory","volume":"109","author":"Golomb","year":"2012","journal-title":"PNAS"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.copsyc.2019.03.018","type":"journal-article","article-title":"Remapping locations and features across saccades: a dual-spotlight theory of attentional updating","volume":"29","author":"Golomb","year":"2019","journal-title":"Current Opinion in Psychology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev-vision-032321-100012","type":"journal-article","article-title":"Visual remapping","volume":"7","author":"Golomb","year":"2021","journal-title":"Annual Review of Vision Science"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.conb.2004.03.002","type":"journal-article","article-title":"An evolving view of duplex vision: separate but interacting cortical pathways for perception and action","volume":"14","author":"Goodale","year":"2004","journal-title":"Current Opinion in Neurobiology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.humov.2006.06.005","type":"journal-article","article-title":"Eye-hand interactions in tracing and drawing tasks","volume":"25","author":"Gowen","year":"2006","journal-title":"Human Movement Science"},{"key":"bib26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2303763120","type":"journal-article","article-title":"Perceptual learning across saccades: feature but not location specific","volume":"120","author":"Grzeczkowski","year":"2023","journal-title":"PNAS"},{"key":"bib27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2316608121","type":"journal-article","article-title":"A computational account of transsaccadic attentional allocation based on visual gain fields","volume":"121","author":"Harrison","year":"2024","journal-title":"PNAS"},{"key":"bib28","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1523\/JNEUROSCI.18-04-01583.1998","type":"journal-article","article-title":"Gaze-centered remapping of remembered visual space in an open-loop pointing task","volume":"18","author":"Henriques","year":"1998","journal-title":"The Journal of Neuroscience"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"76","DOI":"10.5334\/cpsy.116","type":"journal-article","article-title":"Bayesian workflow for generative modeling in computational psychiatry","volume":"9","author":"Hess","year":"2025","journal-title":"Computational Psychiatry"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.tics.2006.10.011","type":"journal-article","article-title":"Space and the parietal cortex","volume":"11","author":"Husain","year":"2007","journal-title":"Trends in Cognitive Sciences"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3758\/BF03205895","type":"journal-article","article-title":"Evidence against visual integration across saccadic eye movements","volume":"34","author":"Irwin","year":"1983","journal-title":"Perception & Psychophysics"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1037\/\/0096-3445.117.3.276","type":"journal-article","article-title":"Visual masking and visual integration across saccadic eye movements","volume":"117","author":"Irwin","year":"1988","journal-title":"Journal of Experimental Psychology. General"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/0010-0285(91)90015-g","type":"journal-article","article-title":"Information integration across saccadic eye movements","volume":"23","author":"Irwin","year":"1991","journal-title":"Cognitive Psychology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1037\/\/0278-7393.18.2.307","type":"journal-article","article-title":"Memory for position and identity across eye movements","volume":"18","author":"Irwin","year":"1992","journal-title":"Journal of Experimental Psychology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1080\/713756783","type":"journal-article","article-title":"Eye movements, attention and trans-saccadic memory","volume":"5","author":"Irwin","year":"1998","journal-title":"Visual Cognition"},{"key":"bib36","type":"software","article-title":"JASP","volume-title":"JASP 0.95.4","author":"JASP Team","year":"2024","unstructured":"JASP Team. 2024. JASP. JASP 0.95.4. https:\/\/jasp-stats.org\/download\/."},{"key":"bib37","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.844341","type":"journal-article","article-title":"Eye-tracking metrics for figure-copying processes in early- vs. late-onset Alzheimer\u2019s Disease","volume":"13","author":"Kim","year":"2022","journal-title":"Frontiers in Neurology"},{"key":"bib38","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab098","type":"journal-article","article-title":"Updating beliefs beyond the here-and-now: the counter-factual self in anosognosia for hemiplegia","volume":"3","author":"Kirsch","year":"2021","journal-title":"Brain Communications"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1068\/v070821","type":"journal-article","article-title":"What\u2019s new in psychtoolbox-3","volume":"36","author":"Kleiner","year":"2007","journal-title":"Perception"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"3559","DOI":"10.1016\/s0042-6989(01)00102-x","type":"journal-article","article-title":"In what ways do eye movements contribute to everyday activities?","volume":"41","author":"Land","year":"2001","journal-title":"Vision Research"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"R811","DOI":"10.1016\/j.cub.2012.06.049","type":"journal-article","article-title":"The operation of the visual system in relation to action","volume":"22","author":"Land","year":"2012","journal-title":"Current Biology"},{"key":"bib42","volume-title":"Information Theory, Inference and Learning Algorithms","author":"MacKay","year":"2003","type":"book"},{"key":"bib43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002575","type":"journal-article","article-title":"Pharmacological fingerprints of contextual uncertainty","volume":"14","author":"Marshall","year":"2016","journal-title":"PLOS Biology"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1212\/01.wnl.0000434309.85312.19","type":"journal-article","article-title":"A brief cognitive test battery to differentiate Alzheimer\u2019s disease and frontotemporal dementia","volume":"55","author":"Mathuranath","year":"2000","journal-title":"Neurology"},{"key":"bib45","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00825","type":"journal-article","article-title":"Uncertainty in perception and the Hierarchical Gaussian Filter","volume":"8","author":"Mathys","year":"2014","journal-title":"Frontiers in Human Neuroscience"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","type":"journal-article","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: Recommendations from the National Institute on Aging\u2010Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1037\/a0017335","type":"journal-article","article-title":"Art students who cannot draw: exploring the relations between drawing ability, visual memory, accuracy of copying, and dyslexia","volume":"4","author":"McManus","year":"2010","journal-title":"Psychology of Aesthetics, Creativity, and the Arts"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.tics.2008.09.003","type":"journal-article","article-title":"Trans-saccadic perception","volume":"12","author":"Melcher","year":"2008","journal-title":"Trends in Cognitive Sciences"},{"key":"bib49","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.98.138104","type":"journal-article","article-title":"Modeling the control of fixational eye movements with neurophysiological delays","volume":"98","author":"Mergenthaler","year":"2007","journal-title":"Physical Review Letters"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/0166-2236(83)90190-X","type":"journal-article","article-title":"Object vision and spatial vision: two cortical pathways","volume":"6","author":"Mishkin","year":"1983","journal-title":"Trends in Neurosciences"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1016\/j.cub.2019.03.069","type":"journal-article","article-title":"A stable visual world in primate primary visual cortex","volume":"29","author":"Morris","year":"2019","journal-title":"Current Biology"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1037\/h0045106","type":"journal-article","article-title":"The serial position effect of free recall","volume":"64","author":"Murdock","year":"1962","journal-title":"Journal of Experimental Psychology"},{"key":"bib53","type":"report","volume-title":"A note on the evidence and Bayesian Occam\u2019s Razor","author":"Murray","year":"2005","unstructured":"Murray I, Ghahramani Z. 2005. Gatsby Computational Neuroscience Unit. A note on the evidence and Bayesian Occam\u2019s Razor."},{"key":"bib54","first-page":"206","type":"journal-article","article-title":"Le test de copie d\u2019une figure complexe; contribution \u00e0 l\u2019\u00e9tude de la perception et de la m\u00e9moire","volume":"30","author":"Osterrieth","year":"1944","journal-title":"Archives de Psychologie"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1016\/s0028-3932(02)00072-6","type":"journal-article","article-title":"Progressive impairment of constructional abilities: a visuospatial sketchpad deficit?","volume":"40","author":"Papagno","year":"2002","journal-title":"Neuropsychologia"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.neuroimage.2011.07.039","type":"journal-article","article-title":"Comparing dynamic causal models using AIC, BIC and free energy","volume":"59","author":"Penny","year":"2012","journal-title":"NeuroImage"},{"key":"bib57","doi-asserted-by":"publisher","DOI":"10.1167\/15.5.5","type":"journal-article","article-title":"Drawing experts have better visual memory while drawing","volume":"15","author":"Perdreau","year":"2015","journal-title":"Journal of Vision"},{"key":"bib58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94247-9","type":"journal-article","article-title":"Automated scoring for a tablet-based rey figure copy task differentiates constructional, organisational, and motor abilities","volume":"11","author":"Petilli","year":"2021","journal-title":"Scientific Reports"},{"key":"bib59","volume-title":"The Retina","author":"Polyak","year":"1941","type":"book"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1152\/jn.1992.67.2.455","type":"journal-article","article-title":"Automatic control during hand reaching at undetected two-dimensional target displacements","volume":"67","author":"Prablanc","year":"1992","journal-title":"Journal of Neurophysiology"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s00221-007-0885-4","type":"journal-article","article-title":"Visual memory capacity in transsaccadic integration","volume":"180","author":"Prime","year":"2007","journal-title":"Experimental Brain Research"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1098\/rstb.2010.0184","type":"journal-article","article-title":"Cortical mechanisms for trans-saccadic memory and integration of multiple object features","volume":"366","author":"Prime","year":"2011","journal-title":"Philosophical Transactions of the Royal Society B"},{"key":"bib63","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s11065-021-09494-4","type":"journal-article","article-title":"The neural bases of drawing. A meta-analysis and a systematic literature review of neurofunctional studies in healthy individuals","volume":"31","author":"Raimo","year":"2021","journal-title":"Neuropsychology Review"},{"key":"bib64","type":"conference-paper","article-title":"Occam\u2019 s razor","author":"Rasmussen","year":"2000","unstructured":"Rasmussen C, Ghahramani Z. 2000. Occam\u2019 s razor. Advances in neural information processing systems."},{"key":"bib65","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/0010-0285(80)90009-2","type":"journal-article","article-title":"Integrating information across eye movements","volume":"12","author":"Rayner","year":"1980","journal-title":"Cognitive Psychology"},{"key":"bib66","first-page":"286","type":"journal-article","article-title":"L\u2019examen psychologique dans les cas d\u2019encephalopathie traumatique","volume":"28","author":"Rey","year":"1941","journal-title":"Archives de Psychologie"},{"key":"bib67","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1093\/brain\/awq052","type":"journal-article","article-title":"A deficit of spatial remapping in constructional apraxia after right-hemisphere stroke","volume":"133","author":"Russell","year":"2010","journal-title":"Brain"},{"key":"bib68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-642-27851-8_215-2","type":"book-chapter","article-title":"Parafovea","volume-title":"Encyclopedia of Color Science and Technology","author":"Sakurai","year":"2020"},{"key":"bib69","doi-asserted-by":"publisher","first-page":"4859","DOI":"10.1523\/JNEUROSCI.3440-17.2018","type":"journal-article","article-title":"Drift in Neural population activity causes working memory to deteriorate over time","volume":"38","author":"Schneegans","year":"2018","journal-title":"The Journal of Neuroscience"},{"key":"bib70","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1080\/09297049.2019.1651834","type":"journal-article","article-title":"Identifying neuropsychological predictors of drawing skills in elementary school children","volume":"26","author":"Senese","year":"2020","journal-title":"Child Neuropsychology"},{"key":"bib71","doi-asserted-by":"publisher","first-page":"E217","DOI":"10.1503\/jpn.220226","type":"journal-article","article-title":"Elevated decision uncertainty and reduced avoidance drives in depression, anxiety and substance use disorders during approach-avoidance conflict: a replication study","volume":"48","author":"Smith","year":"2023","journal-title":"Journal of Psychiatry & Neuroscience"},{"key":"bib72","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1632\/pmla.2017.132.3.668","type":"journal-article","article-title":"All models are wrong","volume":"132","author":"So","year":"2017","journal-title":"PMLA\/Publications of the Modern Language Association of America"},{"key":"bib73","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2023.110945","type":"journal-article","article-title":"Active learning impairments in substance use disorders when resolving the explore-exploit dilemma: a replication and extension of previous computational modeling results","volume":"252","author":"Taylor","year":"2023","journal-title":"Drug and Alcohol Dependence"},{"key":"bib74","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.cortex.2007.12.012","type":"journal-article","article-title":"Eye-hand strategies in copying complex lines","volume":"45","author":"Tchalenko","year":"2009","journal-title":"Cortex; a Journal Devoted to the Study of the Nervous System and Behavior"},{"key":"bib75","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.cortex.2019.06.006","type":"journal-article","article-title":"Trans-saccadic memory after right parietal brain damage","volume":"120","author":"Ten Brink","year":"2019","journal-title":"Cortex; a Journal Devoted to the Study of the Nervous System and Behavior"},{"key":"bib76","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.2501.12081","type":"preprint","article-title":"SPM 25: open source neuroimaging analysis software","volume-title":"arXiv","author":"Tierney","year":"2025"},{"key":"bib77","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cortex.2008.11.015","type":"journal-article","article-title":"Cognitive neuroscience of drawing: contributions of neuropsychological, experimental and neurofunctional studies","volume":"45","author":"Trojano","year":"2009","journal-title":"Cortex; a Journal Devoted to the Study of the Nervous System and Behavior"},{"key":"bib78","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3233\/JAD-160009","type":"journal-article","article-title":"Drawing disorders in Alzheimer\u2019s Disease and other forms of dementia","volume":"53","author":"Trojano","year":"2016","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"bib79","first-page":"549","type":"book-chapter","article-title":"Two cortical visual systems","volume-title":"Analysis of Visual Behavior","author":"Ungerleider","year":"1982"},{"key":"bib80","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1159\/000491634","type":"journal-article","article-title":"Parietal involvement in constructional apraxia as measured using the pentagon copying task","volume":"46","author":"Van der Stigchel","year":"2018","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"key":"bib81","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.neuroimage.2019.06.032","type":"journal-article","article-title":"A guide to group effective connectivity analysis, part 2: Second level analysis with PEB","volume":"200","author":"Zeidman","year":"2019","journal-title":"NeuroImage"},{"key":"bib82","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2023.120310","type":"journal-article","article-title":"A primer on Variational Laplace (VL)","volume":"279","author":"Zeidman","year":"2023","journal-title":"NeuroImage"},{"key":"bib83","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.680474","type":"journal-article","article-title":"Overview of the complex figure test and its clinical application in neuropsychiatric disorders, including copying and recall","volume":"12","author":"Zhang","year":"2021","journal-title":"Frontiers in Neurology"},{"key":"dataset1","type":"dataset","article-title":"Dynamic updating of spatial working memory across eye movements: a computational investigation of transsaccadic integration","volume-title":"Open Science Framework","author":"Zhao","year":"2024","unstructured":"Zhao S. 2024. Dynamic updating of spatial working memory across eye movements: a computational investigation of transsaccadic integration. Open Science Framework. https:\/\/osf.io\/95ecp\/. 95ecp."}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/109581\/elife-109581-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/109581\/elife-109581-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/109581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:07:19Z","timestamp":1787562439000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/109581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":84,"alternative-id":["10.7554\/eLife.109581"],"URL":"https:\/\/doi.org\/10.7554\/elife.109581","archive":["CLOCKSS"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.07.26.666983","asserted-by":"subject"}],"is-same-as":[{"id-type":"doi","id":"10.7554\/eLife.109581.3","asserted-by":"subject"}],"is-version-of":[{"id-type":"doi","id":"10.7554\/eLife.109581.1","asserted-by":"subject"},{"id-type":"doi","id":"10.7554\/eLife.109581.2","asserted-by":"subject"}],"is-financed-by":[{"id-type":"doi","id":"10.35802\/206330","asserted-by":"subject"},{"id-type":"doi","id":"10.35802\/226645","asserted-by":"subject"},{"id-type":"doi","id":"10.35802\/226645","asserted-by":"object"},{"id-type":"doi","id":"10.35802\/206330","asserted-by":"object"}],"is-supplemented-by":[{"id-type":"accession","id":"95ecp","asserted-by":"subject"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,24]]},"assertion":[{"value":"single anonymised","name":"peer_review_transparency","label":"Peer review transparency","group":{"name":"peer_review_taxonomy"}},{"value":"other reviewer(s), editor","name":"peer_review_interaction","label":"Peer review interaction","group":{"name":"peer_review_taxonomy"}},{"value":"review summaries, review reports, author\/editor communication, reviewer identities reviewer opt in, editor identities","name":"peer_review_published","label":"Peer review published","group":{"name":"peer_review_taxonomy"}},{"value":"open (sign in with ORCID iD required)","name":"post_publication_commenting","label":"Post publication commenting","group":{"name":"post_publication_commenting"}}],"article-number":"RP109581"}}