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Although widely supported behaviorally, the theory lacked direct neural evidence. Here, we used event-related functional magnetic resonance imaging (fMRI) in human participants with an optimized cue-target paradigm to test this account. Cued targets elicited stronger activation in the frontoparietal attention networks, including the bilateral frontal eye field (FEF), intraparietal sulcus (IPS), right temporoparietal junction (TPJ), and left dorsal anterior cingulate cortex (dACC), consistent with the notion of attentional demand of reactivating the cue-initiated representations for integration. In contrast, uncued targets engaged the medial temporal cortex, particularly the bilateral parahippocampal gyrus (PHG) and superior temporal gyrus (STG), reflecting the segregation processes associated with new object-file creation and novelty encoding. These dissociable activations provide the first direct neuroimaging evidence for the integration-segregation theory. Moreover, we observed neural interactions between IOR and cognitive conflict, suggesting a potential modulation of conflict processing by attentional orienting. Taken together, these findings provide new insights into exogenous attention by clarifying the neural underpinnings of integration and segregation and uncovering the interaction between spatial orienting and conflict processing.<\/jats:p>","DOI":"10.7554\/elife.109842","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:30:12Z","timestamp":1768249812000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.109842","source":"Crossref","is-referenced-by-count":0,"title":["Dissociable neural substrates of integration and segregation in exogenous attention"],"prefix":"10.7554","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5910-382X","authenticated-orcid":true,"given":"Yujie","family":"Chen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05t8y2r12","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Psychology, Soochow University","place":["Suzhou, 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