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However, the mechanisms underlying the differential regulation of these activities remain unclear. We have previously shown that among the two\n                    <jats:italic>Drosophila<\/jats:italic>\n                    executioner caspases, Dcp-1 and Drice, Dcp-1 promotes tissue growth in a non-lethal manner, independent of canonical apoptotic signaling. Herein, we demonstrated that overexpressed Dcp-1, but not Drice, was activated without canonical apoptosome components. TurboID-based proximity labeling revealed distinct proximal proteomes, among which Sirtuin 1, an Atg8a deacetylase, which promotes autophagy, was specifically required for Dcp-1 activation. Autophagy-related genes, including Bcl-2 family members\n                    <jats:italic>Debcl<\/jats:italic>\n                    and\n                    <jats:italic>Buffy<\/jats:italic>\n                    , are required for Dcp-1 activation. Structure-based prediction using AlphaFold3 further identified Bruce, an autophagy-regulated inhibitor of apoptosis, as a Dcp-1-specific regulator acting outside the apoptosome-mediated pathway. Physiologically, Bruce suppresses wing tissue growth. These findings indicate that non-lethal Dcp-1 activity is governed by the autophagy\u2013Bruce axis, enabling distinct non-lethal functions independent of cell death.\n                  <\/jats:p>","DOI":"10.7554\/elife.109876","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T15:30:14Z","timestamp":1768923014000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.109876","source":"Crossref","is-referenced-by-count":0,"title":["Bruce suppresses autophagy-regulated caspase activity and wing tissue growth in Drosophila"],"prefix":"10.7554","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6668-8747","authenticated-orcid":true,"given":"Natsuki","family":"Shinoda","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/057zh3y96","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo","place":["Tokyo, 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