{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:54:00Z","timestamp":1785437640605,"version":"3.56.0"},"reference-count":8,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>A shift in the balance between two lipids \u2013 cholesterol and sphingomyelin \u2013 makes hybrid epithelial-mesenchymal cancer cells less responsive to certain chemotherapy drugs.<\/jats:p>","DOI":"10.7554\/elife.110231","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:05:07Z","timestamp":1768208707000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.110231","source":"Crossref","is-referenced-by-count":0,"title":["Lipid balance and chemoresistance in cancer cells"],"prefix":"10.7554","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-0229","authenticated-orcid":true,"given":"Kaori","family":"Kanemaru","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05sj3n476","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Applied Biological Science, Faculty of Science and Technology, and the Division of Aging Biology, Research Institute for Science and Technology, Tokyo University of Science","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-1091","authenticated-orcid":true,"given":"Yoshikazu","family":"Nakamura","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05sj3n476","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Applied Biological Science, Faculty of Science and Technology, and the Division of Aging Biology, Research Institute for Science and Technology, Tokyo University of Science","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2026,1,12]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.cell.2018.12.042","type":"journal-article","article-title":"Molecular discrimination between two conformations of sphingomyelin in plasma membranes","volume":"176","author":"Endapally","year":"2019","journal-title":"Cell"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev-pathmechdis-051222-122423","type":"journal-article","article-title":"Update on epithelial-mesenchymal plasticity in cancer progression","volume":"19","author":"Fontana","year":"2024","journal-title":"Annual Review of Pathology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s00280-010-1247-7","type":"journal-article","article-title":"Down-regulation of lipids transporter ABCA1 increases the cytotoxicity of nitidine","volume":"66","author":"Iwasaki","year":"2010","journal-title":"Cancer Chemotherapy and Pharmacology"},{"key":"bib4","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2016.00154","type":"journal-article","article-title":"Sphingolipid organization in the plasma membrane and the mechanisms that influence it","volume":"4","author":"Kraft","year":"2017","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030623","type":"journal-article","article-title":"Hybrid epithelial\/mesenchymal state in cancer metastasis: clinical significance and regulatory mechanisms","volume":"9","author":"Liao","year":"2020","journal-title":"Cells"},{"key":"bib6","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.104374","type":"journal-article","article-title":"Chemotherapy resistance due to epithelial-to-mesenchymal transition is caused by abnormal lipid metabolic balance","volume":"13","author":"Matsumoto","year":"2024","journal-title":"eLife"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1010687","type":"journal-article","article-title":"Network topology metrics explaining enrichment of hybrid epithelial\/mesenchymal phenotypes in metastasis","volume":"18","author":"Rashid","year":"2022","journal-title":"PLOS Computational Biology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41574-018-0037-x","type":"journal-article","article-title":"Liver X receptors in lipid signalling and membrane homeostasis","volume":"14","author":"Wang","year":"2018","journal-title":"Nature Reviews Endocrinology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/110231\/elife-110231-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/110231\/elife-110231-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/110231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T09:05:42Z","timestamp":1768208742000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/110231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,12]]},"references-count":8,"alternative-id":["10.7554\/eLife.110231"],"URL":"https:\/\/doi.org\/10.7554\/elife.110231","archive":["CLOCKSS"],"relation":{},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,12]]},"article-number":"e110231"}}