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At this site, podoplanin-expressing cells, including lymphatic vessels and meningeal layers, expand to create a distinct drainage microenvironment. In this study, we sought to characterize myeloid cells, which populate this region, using a mouse model of neuroinflammation, experimental autoimmune encephalomyelitis. Utilizing a combination of immunohistochemistry, flow cytometry, and scRNAseq, we report that macrophages and dendritic cells from this region display unique expressional signatures related to tolerance, cell death, and reduced inflammatory profile. Together, this data supports that myeloid retention at the cribriform plate and olfactory bulb meninges promotes a local immunosuppressive environment.\n                  <\/jats:p>","DOI":"10.7554\/elife.110460","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T14:32:38Z","timestamp":1772029958000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.110460","source":"Crossref","is-referenced-by-count":1,"title":["Cribriform plate microenvironment assembles a suppressive myeloid network during EAE-induced neuroinflammation"],"prefix":"10.7554","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8532-9427","authenticated-orcid":true,"given":"Collin","family":"Laaker","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01y2jtd41","id-type":"ROR","asserted-by":"publisher"}],"name":"Neuroscience Training Program, University of Wisconsin Madison","place":["Madison, United 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