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However, the cognate parasite ligand for LFA-1 has remained unknown. Here, we identify glycophorin binding protein-130 (\n                    <jats:italic>Pf<\/jats:italic>\n                    GBP-130) as a surface-expressed ligand on iRBCs that binds the I-domain of LFA-1 (LFA-1 \u03b1I). Using an LFA-1 \u03b1I-Fc fusion protein, we demonstrate stage-specific binding to iRBCs, and LC-MS\/MS analysis of immunoprecipitates of \u03b1I-Fc bound to iRBC revealed\n                    <jats:italic>Pf<\/jats:italic>\n                    GBP-130 as a high-confidence interactor. Recombinant\n                    <jats:italic>Pf<\/jats:italic>\n                    GBP-130 binds NK and THP-1 cells in an LFA-1-dependent manner. Co-culture assays show that\n                    <jats:italic>Pf<\/jats:italic>\n                    GBP-130 promotes NK cell activation and degranulation and facilitates contact-dependent killing of iRBCs. Neutralizing antibodies against\n                    <jats:italic>Pf<\/jats:italic>\n                    GBP-130 significantly impair these responses. Our findings establish\n                    <jats:italic>Pf<\/jats:italic>\n                    GBP-130 as the LFA-1 ligand on iRBCs, providing new insight into NK cell-mediated immunity in malaria and identifying a potential target for host-directed interventions.\n                  <\/jats:p>","DOI":"10.7554\/elife.110942","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T14:30:14Z","timestamp":1775053814000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.110942","source":"Crossref","is-referenced-by-count":0,"title":["LFA-1 interaction with GBP-130 on Plasmodium falciparum-infected red blood cells mediates NK cell activation and parasite control"],"prefix":"10.7554","volume":"15","author":[{"given":"Osama","family":"Mukhtar","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03j4rrt43","id-type":"ROR","asserted-by":"publisher"}],"name":"Malaria Biology Group, International Centre for Genetic Engineering and Biotechnology 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