{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:50:54Z","timestamp":1785412254293,"version":"3.56.0"},"reference-count":14,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The asymmetry of lipid membranes is tightly regulated in eukaryotic cells, and auditory hair cells are no exception.<\/jats:p>","DOI":"10.7554\/elife.111563","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:15:06Z","timestamp":1776849306000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.111563","source":"Crossref","is-referenced-by-count":0,"title":["Examining the role of lipids in hearing"],"prefix":"10.7554","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5011-7421","authenticated-orcid":true,"given":"Yein Christina","family":"Park","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mhx6838","id-type":"ROR","asserted-by":"publisher"}],"name":"Section on Sensory Physiology and Biophysics, National Institute on Deafness and other Communication Disorders","place":["Bethesda, United States"]},{"id":[{"id":"https:\/\/ror.org\/00za53h95","id-type":"ROR","asserted-by":"publisher"}],"name":"Graduate Program in Cell, Molecular, Developmental Biology and Biophysics, Johns Hopkins University","place":["Baltimore, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5796-6875","authenticated-orcid":true,"given":"Angela","family":"Ballesteros","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mhx6838","id-type":"ROR","asserted-by":"publisher"}],"name":"Section on Sensory Physiology and Biophysics, National Institute on Deafness and other Communication Disorders","place":["Bethesda, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abm5550","type":"journal-article","article-title":"Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing","volume":"8","author":"Ballesteros","year":"2022","journal-title":"Science Advances"},{"key":"bib2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2502798122","type":"journal-article","article-title":"ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D","volume":"122","author":"Bhandari","year":"2025","journal-title":"PNAS"},{"key":"bib3","doi-asserted-by":"publisher","DOI":"10.1101\/2025.04.01.646713","type":"preprint","article-title":"PIP2-Tmie interactions drive mammalian hair cell slow adaptation independently of myosin motors","volume-title":"bioRxiv","author":"Caprara","year":"2025"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.neuron.2020.03.033","type":"journal-article","article-title":"TMIE defines pore and gating properties of the mechanotransduction channel of mammalian cochlear hair cells","volume":"107","author":"Cunningham","year":"2020","journal-title":"Neuron"},{"key":"bib5","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.110466","type":"journal-article","article-title":"ATP8B1-TMEM30B flippase activity maintains stereocilia lipid asymmetry required for hearing","volume":"15","author":"De Hoyos","year":"2026","journal-title":"eLife"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"11632","DOI":"10.1523\/JNEUROSCI.1351-17.2017","type":"journal-article","article-title":"Phosphoinositol-4,5-bisphosphate regulates auditory hair-cell mechanotransduction-channel pore properties and fast adaptation","volume":"37","author":"Effertz","year":"2017","journal-title":"Journal of Neuroscience"},{"key":"bib7","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202508268","type":"journal-article","article-title":"Auditory hair cell mechanotransduction channels dynamically shape the mechanical properties of their membrane environment","volume":"13","author":"George","year":"2026","journal-title":"Advanced Science"},{"key":"bib8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00061-1","type":"journal-article","article-title":"CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells","volume":"8","author":"Giese","year":"2017","journal-title":"Nature Communications"},{"key":"bib9","doi-asserted-by":"publisher","DOI":"10.1101\/2025.07.03.663083","type":"preprint","article-title":"TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells","volume-title":"bioRxiv","author":"Lee","year":"2025"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1016\/j.neuron.2021.05.007","type":"journal-article","article-title":"CIB2 and CIB3 are auxiliary subunits of the mechanotransduction channel of hair cells","volume":"109","author":"Liang","year":"2021","journal-title":"Neuron"},{"key":"bib11","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2025.109229","type":"journal-article","article-title":"Mammalian TMC1 or 2 are necessary for scramblase activity in auditory hair cells","volume":"460","author":"Peineau","year":"2025","journal-title":"Hearing Research"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41580-023-00604-z","type":"journal-article","article-title":"Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases","volume":"24","author":"Sakuragi","year":"2023","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"9709","DOI":"10.1073\/pnas.0807919106","type":"journal-article","article-title":"ATP8B1 is essential for maintaining normal hearing","volume":"106","author":"Stapelbroek","year":"2009","journal-title":"PNAS"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.tins.2019.03.006","type":"journal-article","article-title":"Mechanisms of hair cell damage and repair","volume":"42","author":"Wagner","year":"2019","journal-title":"Trends in Neurosciences"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/111563\/elife-111563-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/111563\/elife-111563-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/111563","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:05:45Z","timestamp":1778659545000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/111563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":14,"alternative-id":["10.7554\/eLife.111563"],"URL":"https:\/\/doi.org\/10.7554\/elife.111563","archive":["CLOCKSS"],"relation":{},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"article-number":"e111563"}}