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Yet, the mechanisms driving the hippocampal-dependent cognitive atypicalities in autism remain poorly defined. Here, we characterized how dysfunction of the CA1 subfield of the dorsal hippocampus drives abnormalities in critical components of declarative memory. Using trace fear conditioning in the\n                    <jats:italic>Cntnap2<\/jats:italic>\n                    knockout mouse model of autism, we found that capabilities to retain the association of temporally distant stimuli (i.e. temporal binding) were reduced relative to wildtype mice. Fiber photometry and optogenetic experiments demonstrated that reduced CA1 activity during temporal gaps underlies this impairment, linking CA1 dysfunction to a deficit in long-term memory retention in autism. Using a relational\/declarative memory task, we also revealed a deficit in flexible spatial memory, and a preferential use of egocentric learning strategy. This inflexible learning strategy resulted from an imbalance between memory system activity, promoting frontostriatal-dependent procedural learning instead of dorsal CA1\/hippocampus-dependent relational\/declarative memory. Overall, this study establishes dorsal CA1 dysfunction as a circuit-level mechanism underlying cognitive inflexibility in autism, providing a neurobiological framework for hippocampal-dependent memory deficits in the condition.\n                  <\/jats:p>","DOI":"10.7554\/elife.111851","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:30:30Z","timestamp":1786717830000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.111851","source":"Crossref","is-referenced-by-count":0,"title":["Reduced dorsal CA1 activity limits retention of the temporal component of declarative memory in the Cntnap2 knockout mouse model of autism"],"prefix":"10.7554","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5915-8019","authenticated-orcid":true,"given":"Elise Caitlin","family":"Rawlinson","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/019wvm592","id-type":"ROR","asserted-by":"publisher"}],"name":"Eccles Institute of 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