{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T17:08:45Z","timestamp":1753895325034,"version":"3.41.2"},"reference-count":10,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Antimicrobial proteins deliver a double punch that can destroy the Toxoplasma gondii parasite and its niche inside cells.<\/jats:p>","DOI":"10.7554\/elife.14729","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T12:00:01Z","timestamp":1455883201000},"source":"Crossref","is-referenced-by-count":0,"title":["Intracellular pathogens under attack"],"prefix":"10.7554","volume":"5","author":[{"given":"Petr","family":"Broz","sequence":"first","affiliation":[{"name":"Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4374","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"7729","DOI":"10.4049\/jimmunol.179.11.7729","article-title":"Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense","volume":"179","author":"Degrandi","year":"2007","journal-title":"Journal of Immunology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1073\/pnas.1205635110","article-title":"Murine guanylate binding protein 2 (mGBP2) controls toxoplasma gondii replication","volume":"110","author":"Degrandi","year":"2013","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nrm3266","article-title":"Dynamin, a membrane-remodelling GTPase","volume":"13","author":"Ferguson","year":"2012","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"E5628","DOI":"10.1073\/pnas.1515966112","article-title":"Ubiquitin systems mark pathogen-containing vacuoles as targets for host defense by guanylate binding proteins","volume":"112","author":"Haldar","year":"2015","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"e11479","DOI":"10.7554\/eLife.11479","article-title":"Guanylate binding proteins (gBPs) directly attack t. gondii via supramolecular complexes","volume":"5:","author":"Kravets","year":"2016","journal-title":"eLife"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"27452","DOI":"10.1074\/jbc.M112.379636","article-title":"The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of toxoplasma gondii","volume":"287","author":"Kravets","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jmb.2004.09.026","article-title":"Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis","volume":"344","author":"Praefcke","year":"2004","journal-title":"Journal of Molecular Biology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"e1003320","DOI":"10.1371\/journal.ppat.1003320","article-title":"Guanylate-binding protein 1 (Gbp1) contributes to cell-autonomous immunity against toxoplasma gondii","volume":"9","author":"Selleck","year":"2013","journal-title":"PLoS Pathogens"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.immuni.2012.06.009","article-title":"A cluster of interferon-\u03b3-inducible p65 GTPases plays a critical role in host defense against toxoplasma gondii","volume":"37","author":"Yamamoto","year":"2012","journal-title":"Immunity"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"e1000288","DOI":"10.1371\/journal.ppat.1000288","article-title":"Disruption of the toxoplasma gondii parasitophorous vacuole by IFN\u03b3-inducible immunity-related GTPases (iRG proteins) triggers necrotic cell death","volume":"5","author":"Zhao","year":"2009","journal-title":"PLoS Pathogens"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/14729\/elife-14729-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/14729\/elife-14729-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/14729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:50:18Z","timestamp":1697071818000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/14729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,19]]},"references-count":10,"alternative-id":["10.7554\/eLife.14729"],"URL":"https:\/\/doi.org\/10.7554\/elife.14729","archive":["CLOCKSS"],"relation":{},"ISSN":["2050-084X"],"issn-type":[{"type":"electronic","value":"2050-084X"}],"subject":[],"published":{"date-parts":[[2016,2,19]]},"article-number":"e14729"}}