{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:29:10Z","timestamp":1790980150200,"version":"4.1.0"},"reference-count":62,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T00:00:00Z","timestamp":1468540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006352","name":"Virginia and D.K. Ludwig Fund for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006352","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Banyan Gate Foundation"},{"name":"Sol Goldman Sequencing Facility at Johns Hopkins"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA43460"],"award-info":[{"award-number":["CA43460"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["10-0699"],"award-info":[{"award-number":["10-0699"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BioCARE Program at the University of Gothenburg","award":["9\/14-15"],"award-info":[{"award-number":["9\/14-15"]}]},{"name":"Access to Learning Fund","award":["LUA\/ALF Grant 70950"],"award-info":[{"award-number":["LUA\/ALF Grant 70950"]}]},{"name":"WeCanCureCancer"}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>We determined whether the mutations found in ovarian cancers could be identified in the patients' ovarian cyst fluids. Tumor-specific mutations were detectable in the cyst fluids of 19 of 23 (83%) borderline tumors, 10 of 13 (77%) type I cancers, and 18 of 18 (100%) type II cancers. In contrast, no mutations were found in the cyst fluids of 18 patients with benign tumors or non-neoplastic cysts. Though large, prospective studies are needed to demonstrate the safety and clinical utility of this approach, our results suggest that the genetic evaluation of cyst fluids might be able to inform the management of the large number of women with these lesions.<\/jats:p>","DOI":"10.7554\/elife.15175","type":"journal-article","created":{"date-parts":[[2016,7,15]],"date-time":"2016-07-15T08:10:03Z","timestamp":1468570203000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.15175","source":"Crossref","is-referenced-by-count":38,"title":["Diagnostic potential of tumor DNA from ovarian cyst fluid"],"prefix":"10.7554","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2932-6042","authenticated-orcid":true,"given":"Yuxuan","family":"Wang","sequence":"first","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Sundfeldt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantina","family":"Mateoiu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ie-Ming","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, United States"},{"name":"Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Kurman","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Johns Hopkins Medical Institutes, Baltimore, United States"},{"name":"Department of Gynecology and Obstetrics, The Johns Hopkins Medical Institutions, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Silliman","sequence":"additional","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Kinde","sequence":"additional","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeon","family":"Springer","sequence":"additional","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Foote","sequence":"additional","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Swim Across America Laboratory, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rg","family":"Kristjansdottir","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Cancer Center, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"James","sequence":"additional","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W","family":"Kinzler","sequence":"additional","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nickolas","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A","family":"Diaz","sequence":"additional","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Swim Across America Laboratory, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-3854","authenticated-orcid":true,"given":"Bert","family":"Vogelstein","sequence":"additional","affiliation":[{"name":"Ludwig Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"},{"name":"Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1056\/NEJMoa052985","article-title":"Intraperitoneal cisplatin and paclitaxel in ovarian cancer","volume":"354","author":"Armstrong","year":"2006","journal-title":"New England Journal of Medicine"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1515\/cclm-2013-0151","article-title":"Cancer antigen 125, human epididymis 4, kallikrein 6, osteopontin and soluble mesothelin-related peptide immunocomplexed with immunoglobulin M in epithelial ovarian cancer diagnosis","volume":"51","author":"Bandiera","year":"2013","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1089\/thy.2013.0403","article-title":"Prevalence, tumorigenic role, and biochemical implications of rare BRAF alterations","volume":"24","author":"Barollo","year":"2014","journal-title":"Thyroid"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1056\/NEJM198310133091503","article-title":"A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer","volume":"309","author":"Bast","year":"1983","journal-title":"New England Journal of Medicine"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.surg.2011.07.068","article-title":"Outcomes after preoperative endoscopic ultrasonography and biopsy in patients undergoing distal pancreatectomy","volume":"150","author":"Beane","year":"2011","journal-title":"Surgery"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"224ra24","DOI":"10.1126\/scitranslmed.3007094","article-title":"Detection of circulating tumor DNA in early- and late-stage human malignancies","volume":"6","author":"Bettegowda","year":"2014","journal-title":"Science Translational Medicine"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1200\/JCO.20.5.1248","article-title":"Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis","volume":"20","author":"Bristow","year":"2002","journal-title":"Journal of Clinical Oncology"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.ajog.2005.05.005","article-title":"Ovarian cancer screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial: findings from the initial screen of a randomized trial","volume":"193","author":"Buys","year":"2005","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1001\/jama.2011.766","article-title":"Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening randomized controlled trial","volume":"305","author":"Buys","year":"2011","journal-title":"Journal of the American Medical Association"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nature10166","article-title":"Integrated genomic analyses of ovarian carcinoma","volume":"474","author":"Cancer Genome Atlas Research Network","year":"2011","journal-title":"Nature"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0016-5107(97)70149-4","article-title":"The clinical utility of endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of pancreatic carcinoma","volume":"45","author":"Chang","year":"1997","journal-title":"Gastrointestinal Endoscopy"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1038\/labinvest.3700103","article-title":"Molecular genetic analysis of ovarian serous cystadenomas","volume":"84","author":"Cheng","year":"2004","journal-title":"Laboratory Investigation"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0010-7824(02)00353-0","article-title":"Functional ovarian cysts in premenopausal and gynecologically healthy women","volume":"66","author":"Christensen","year":"2002","journal-title":"Contraception"},{"key":"bib14","first-page":"5761","article-title":"Absence of BRAF and NRAS mutations in uveal melanoma","volume":"63","author":"Cruz","year":"2003","journal-title":"Cancer Research"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/nature00766","article-title":"Mutations of the BRAF gene in human cancer","volume":"417","author":"Davies","year":"2002","journal-title":"Nature"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/S1472-6483(10)61192-3","article-title":"Effect of endometrioma cystectomy on IVF outcome: a prospective randomized study","volume":"12","author":"Demirol","year":"2006","journal-title":"Reproductive Biomedicine Online"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00270-005-0167-0","article-title":"Transvaginal aspiration of ovarian cysts: long-term follow-up","volume":"29","author":"Duke","year":"2006","journal-title":"Cardiovascular and Interventional Radiology"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1111\/j.1572-0241.2003.08666.x","article-title":"Endoscopic ultrasound-guided fine needle aspiration biopsy of patients with suspected pancreatic cancer: diagnostic accuracy and acute and 30-day complications","volume":"98","author":"Eloubeidi","year":"2003","journal-title":"American Journal of Gastroenterology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1111\/j.1572-0241.2003.07530.x","article-title":"Performance of endosonography-guided fine needle aspiration and biopsy in the diagnosis of pancreatic cystic lesions","volume":"98","author":"Frossard","year":"2003","journal-title":"American Journal of Gastroenterology"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S1470-2045(11)70333-3","article-title":"Assessment of symptomatic women for early diagnosis of ovarian cancer: results from the prospective DOvE pilot project","volume":"13","author":"Gilbert","year":"2012","journal-title":"Lancet. Oncology"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1002\/cncr.27782","article-title":"BRAF mutation is associated with early stage disease and improved outcome in patients with low-grade serous ovarian cancer","volume":"119","author":"Grisham","year":"2013","journal-title":"Cancer"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/00006250-200308000-00008","article-title":"Predictors of clinical outcomes in the laparoscopic management of adnexal masses","volume":"102","author":"Havrilesky","year":"2003","journal-title":"Obstetrics and Gynecology"},{"key":"bib23","first-page":"3695","article-title":"The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma","volume":"63","author":"Hellstr\u00f6m","year":"2003","journal-title":"Cancer Research"},{"key":"bib24","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/00003081-200609000-00013","article-title":"Laparoscopic management of the adnexal mass","volume":"49","author":"Hilger","year":"2006","journal-title":"Clinical Obstetrics and Gynecology"},{"key":"bib25","volume-title":"SEER Cancer Statistics Review, 1975-2011","author":"Howlader","year":"2014"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1002\/path.3967","article-title":"Low-grade serous carcinomas of the ovary contain very few point mutations","volume":"226","author":"Jones","year":"2012","journal-title":"Journal of Pathology"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ejso.2012.12.003","article-title":"Impact of intraoperative rupture of the ovarian capsule on prognosis in patients with early-stage epithelial ovarian cancer: a meta-analysis","volume":"39","author":"Kim","year":"2013","journal-title":"European Journal of Surgical Oncology"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"9530","DOI":"10.1073\/pnas.1105422108","article-title":"Detection and quantification of rare mutations with massively parallel sequencing","volume":"108","author":"Kinde","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"167ra4","DOI":"10.1126\/scitranslmed.3004952","article-title":"Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers","volume":"5","author":"Kinde","year":"2013","journal-title":"Science Translational Medicine"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1559-0275-10-4","article-title":"Potential tumor biomarkers identified in ovarian cyst fluid by quantitative proteomic analysis, iTRAQ","volume":"10","author":"Kristjansdottir","year":"2013","journal-title":"Clinical Proteomics"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"3620","DOI":"10.3748\/wjg.v20.i13.3620","article-title":"Influence of the safety and diagnostic accuracy of preoperative endoscopic ultrasound-guided fine-needle aspiration for resectable pancreatic cancer on clinical performance","volume":"20","author":"Kudo","year":"2014","journal-title":"World Journal of Gastroenterology"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1097\/PAS.0b013e3181cf3d79","article-title":"The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory","volume":"34","author":"Kurman","year":"2010","journal-title":"American Journal of Surgical Pathology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.humpath.2011.03.003","article-title":"Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer--shifting the paradigm","volume":"42","author":"Kurman","year":"2011","journal-title":"Human Pathology"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/path.2091","article-title":"A candidate precursor to serous carcinoma that originates in the distal fallopian tube","volume":"211","author":"Lee","year":"2007","journal-title":"Journal of Pathology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1148\/radiol.10100213","article-title":"Management of asymptomatic ovarian and other adnexal cysts imaged at US: society of radiologists in ultrasound consensus conference statement","volume":"256","author":"Levine","year":"2010","journal-title":"Radiology"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1089\/thy.2005.15.708","article-title":"Thyroid cancer in the thyroid nodules evaluated by ultrasonography and fine-needle aspiration cytology","volume":"15","author":"Lin","year":"2005","journal-title":"Thyroid"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/S0015-0282(99)00207-1","article-title":"Ovarian response after laparoscopic ovarian cystectomy for endometriotic cysts in 132 monitored cycles","volume":"72","author":"Loh","year":"1999","journal-title":"Fertility and Sterility"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1159\/000328368","article-title":"Aspiration cytology of 147 adnexal cysts with histologic correlation","volume":"45","author":"Mart\u00ednez-Onsurbe","year":"2001","journal-title":"Acta Cytologica"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.ygyno.2006.05.029","article-title":"KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants","volume":"103","author":"Mayr","year":"2006","journal-title":"Gynecologic Oncology"},{"key":"bib40","first-page":"444","article-title":"Cytologic examination of ovarian cyst fluid for the distinction between benign and malignant tumors","volume":"82","author":"Moran","year":"1993","journal-title":"Obstetrics and Gynecology"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"900","DOI":"10.7326\/0003-4819-157-11-201212040-00539","article-title":"Screening for ovarian cancer: U.S. preventive services task force reaffirmation recommendation statement","volume":"157","author":"Moyer","year":"2012","journal-title":"Annals of Internal Medicine"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1159\/000334002","article-title":"Aspiration cytology of ovarian cysts and cystic neoplasms. A study of 235 aspirates","volume":"40","author":"Mulvany","year":"1996","journal-title":"Acta Cytologica"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nature12065","article-title":"Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA","volume":"497","author":"Murtaza","year":"2013","journal-title":"Nature"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/nm.3519","article-title":"An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage","volume":"20","author":"Newman","year":"2014","journal-title":"Nature Medicine"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1055\/s-0033-1344216","article-title":"Risk of gastric or peritoneal recurrence, and long-term outcomes, following pancreatic cancer resection with preoperative endosonographically guided fine needle aspiration","volume":"45","author":"Ngamruengphong","year":"2013","journal-title":"Endoscopy"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1136\/gutjnl-2014-307475","article-title":"Preoperative endoscopic ultrasound-guided fine needle aspiration does not impair survival of patients with resected pancreatic cancer","volume":"64","author":"Ngamruengphong","year":"2015","journal-title":"Gut"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1097\/AOG.0b013e318298def5","article-title":"Frequency and disposition of ovarian abnormalities followed with serial transvaginal ultrasonography","volume":"122","author":"Pavlik","year":"2013","journal-title":"Obstetrics and Gynecology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"9364","DOI":"10.1158\/0008-5472.CAN-07-0605","article-title":"Serial assessment of human tumor burdens in mice by the analysis of circulating DNA","volume":"67","author":"Rago","year":"2007","journal-title":"Cancer Research"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.ygyno.2007.11.013","article-title":"Neoadjuvant chemotherapy for low-grade serous carcinoma of the ovary or peritoneum","volume":"108","author":"Schmeler","year":"2008","journal-title":"Gynecologic Oncology"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1002\/uog.12270","article-title":"Risk of epithelial ovarian cancer in asymptomatic women with ultrasound-detected ovarian masses: a prospective cohort study within the UK collaborative trial of ovarian cancer screening (UKCTOCS)","volume":"40","author":"Sharma","year":"2012","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1002\/cncr.20080","article-title":"Survival among women with borderline ovarian tumors and ovarian carcinoma: a population-based analysis","volume":"100","author":"Sherman","year":"2004","journal-title":"Cancer"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.ygyno.2010.11.016","article-title":"Risk factors for recurrence of ovarian borderline tumors","volume":"120","author":"Shih","year":"2011","journal-title":"Gynecologic Oncology"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1200\/JCO.2014.55.9898","article-title":"Long-term survival advantage and prognostic factors associated with intraperitoneal chemotherapy treatment in advanced ovarian cancer: a gynecologic oncology group study","volume":"33","author":"Tewari","year":"2015","journal-title":"Journal of Clinical Oncology"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1007\/s00270-013-0823-8","article-title":"Tract embolization with gelatin sponge slurry for prevention of pneumothorax after percutaneous computed tomography-guided lung biopsy","volume":"37","author":"Tran","year":"2014","journal-title":"Cardiovascular and Interventional Radiology"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1002\/path.4252","article-title":"KRAS (but not BRAF) mutations in ovarian serous borderline tumour are associated with recurrent low-grade serous carcinoma","volume":"231","author":"Tsang","year":"2013","journal-title":"Journal of Pathology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"107","DOI":"10.12809\/hkmj133972","article-title":"Ultrasound-guided plugged percutaneous biopsy of solid organs in patients with bleeding tendencies","volume":"20","author":"Tsang","year":"2014","journal-title":"Hong Kong Medical Journal"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1097\/AOG.0b013e31821b5118","article-title":"Effectiveness of a multivariate index assay in the preoperative assessment of ovarian tumors","volume":"117","author":"Ueland","year":"2011","journal-title":"Obstetrics and Gynecology"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes","volume":"339","author":"Vogelstein","year":"2013","journal-title":"Science"},{"key":"bib59","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.juro.2007.03.131","article-title":"Techniques, safety and accuracy of sampling of renal tumors by fine needle aspiration and core biopsy","volume":"178","author":"Volpe","year":"2007","journal-title":"Journal of Urology"},{"key":"bib60","doi-asserted-by":"publisher","first-page":"21188","DOI":"10.1073\/pnas.1118046108","article-title":"Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways","volume":"108","author":"Wu","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"bib61","doi-asserted-by":"publisher","first-page":"92ra66","DOI":"10.1126\/scitranslmed.3002543","article-title":"Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development","volume":"3","author":"Wu","year":"2011","journal-title":"Science Translational Medicine"},{"key":"bib62","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.ejogrb.2013.08.003","article-title":"Is it possible to diagnose malignancy from fluid in cystic ovarian tumors?","volume":"171","author":"Yamada","year":"2013","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/15175\/elife-15175-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/15175\/elife-15175-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/15175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:50:55Z","timestamp":1697057455000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/15175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,15]]},"references-count":62,"alternative-id":["10.7554\/eLife.15175"],"URL":"https:\/\/doi.org\/10.7554\/elife.15175","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.15175.013","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.15175.012","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,15]]},"article-number":"e15175"}}