{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:47:09Z","timestamp":1791521229749,"version":"4.3.4"},"reference-count":50,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["Postdoctoral Fellowship"],"award-info":[{"award-number":["Postdoctoral Fellowship"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHE 1575\/3-1"],"award-info":[{"award-number":["SCHE 1575\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BCCN-II, 01GQ1005C"],"award-info":[{"award-number":["BCCN-II, 01GQ1005C"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7-611687 (NEBIAS)"],"award-info":[{"award-number":["FP7-611687 (NEBIAS)"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Grasping requires translating object geometries into appropriate hand shapes. How the brain computes these transformations is currently unclear. We investigated three key areas of the macaque cortical grasping circuit with microelectrode arrays and found cooperative but anatomically separated visual and motor processes. The parietal area AIP operated primarily in a visual mode. Its neuronal population revealed a specialization for shape processing, even for abstract geometries, and processed object features ultimately important for grasping. Premotor area F5 acted as a hub that shared the visual coding of AIP only temporarily and switched to highly dominant motor signals towards movement planning and execution. We visualize these non-discrete premotor signals that drive the primary motor cortex M1 to reflect the movement of the grasping hand. Our results reveal visual and motor features encoded in the grasping circuit and their communication to achieve transformation for grasping.<\/jats:p>","DOI":"10.7554\/elife.15278","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T19:59:29Z","timestamp":1469476769000},"source":"Crossref","is-referenced-by-count":114,"title":["Object vision to hand action in macaque parietal, premotor, and motor cortices"],"prefix":"10.7554","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-971X","authenticated-orcid":true,"given":"Stefan","family":"Schaffelhofer","sequence":"first","affiliation":[{"name":"Neurobiology Laboratory, German Primate Center GmbH, G\u00f6ttingen, Germany"},{"name":"Laboratory of Neural Systems, The Rockefeller University, New York, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6593-2800","authenticated-orcid":true,"given":"Hansj\u00f6rg","family":"Scherberger","sequence":"additional","affiliation":[{"name":"Neurobiology Laboratory, German Primate Center GmbH, G\u00f6ttingen, Germany"},{"name":"Department of Biology, University of G\u00f6ttingen, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"6436","DOI":"10.1523\/JNEUROSCI.5479-08.2009","article-title":"Context-specific grasp movement representation in the macaque anterior intraparietal area","volume":"29","author":"Baumann","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1002\/cne.21892","article-title":"Multimodal architectonic subdivision of the rostral part (area F5) of the macaque ventral premotor cortex","volume":"512","author":"Belmalih","year":"2009","journal-title":"Journal of Comparative Neurology"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1037\/0033-295X.94.2.115","article-title":"Recognition-by-components: a theory of human image understanding","volume":"94","author":"Biederman","year":"1987","journal-title":"Psychological Review"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1093\/cercor\/bhm146","article-title":"Cortical connections of the macaque anterior intraparietal (AIP) area","volume":"18","author":"Borra","year":"2008","journal-title":"Cerebral Cortex"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"2570","DOI":"10.1002\/cne.22353","article-title":"Projections of the hand field of the macaque ventral premotor area F5 to the brainstem and spinal cord","volume":"518","author":"Borra","year":"2010","journal-title":"The Journal of Comparative Neurology"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.conb.2007.12.002","article-title":"Cortical control of grasp in non-human primates","volume":"17","author":"Brochier","year":"2007","journal-title":"Current Opinion in Neurobiology"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nrn1744","article-title":"The neuroscience of grasping","volume":"6","author":"Castiello","year":"2005","journal-title":"Nature Reviews. Neuroscience"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s00221-003-1591-5","article-title":"Visually guided grasping produces fMRI activation in dorsal but not ventral stream brain areas","volume":"153","author":"Culham","year":"2003","journal-title":"Experimental Brain Research"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.conb.2011.05.021","article-title":"Interactions between areas of the cortical grasping network","volume":"21","author":"Davare","year":"2011","journal-title":"Current Opinion in Neurobiology"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1109\/TBME.2007.901024","article-title":"OpenSim: open-source software to create and analyze dynamic simulations of movement","volume":"54","author":"Delp","year":"2007","journal-title":"IEEET Biomed Eng"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1523\/JNEUROSCI.3902-04.2005","article-title":"Frontal lobe inputs to the digit representations of the motor areas on the lateral surface of the hemisphere","volume":"25","author":"Dum","year":"2005","journal-title":"Journal of Neuroscience"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/S0893-6080(98)00047-1","article-title":"Modeling parietal-premotor interactions in primate control of grasping","volume":"11","author":"Fagg","year":"1998","journal-title":"Neural Networks"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/cercor\/1.1.1","article-title":"Distributed hierarchical processing in the primate cerebral cortex","volume":"1","author":"Felleman","year":"1991","journal-title":"Cerebral Cortex"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"15175","DOI":"10.1523\/JNEUROSCI.3343-10.2010","article-title":"Context-specific grasp movement representation in macaque ventral premotor cortex","volume":"30","author":"Fluet","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1093\/brain\/124.3.571","article-title":"Cortical mechanism for the visual guidance of hand grasping movements in the monkey: A reversible inactivation study","volume":"124","author":"Fogassi","year":"2001","journal-title":"Brain\u00a0"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1097\/00001756-199407000-00029","article-title":"Deficit of hand preshaping after muscimol injection in monkey parietal cortex","volume":"5","author":"Gallese","year":"1994","journal-title":"Neuroreport"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00429-010-0293-6","article-title":"Cortical connections of the anterior (F5a) subdivision of the macaque ventral premotor area F5","volume":"216","author":"Gerbella","year":"2011","journal-title":"Brain Structure & Function"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/S0960-9822(00)00132-9","article-title":"Separate neural pathways for the visual analysis of object shape in perception and prehension","volume":"4","author":"Goodale","year":"1994","journal-title":"Current Biology"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/BF00231054","article-title":"Factors affecting higher-order movement planning: a kinematic analysis of human prehension","volume":"86","author":"Jakobson","year":"1991","journal-title":"Experimental Brain Research"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/0166-2236(95)93921-J","article-title":"Grasping objects: the cortical mechanisms of visuomotor transformation","volume":"18","author":"Jeannerod","year":"1995","journal-title":"Trends in Neurosciences"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"8812","DOI":"10.1523\/JNEUROSCI.0525-11.2011","article-title":"Ventral premotor-motor cortex interactions in the macaque monkey during grasp: response of single neurons to intracortical microstimulation","volume":"31","author":"Kraskov","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/S0960-9822(95)00108-4","article-title":"Shape representation in the inferior temporal cortex of monkeys","volume":"5","author":"Logothetis","year":"1995","journal-title":"Current Biology"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s002210050833","article-title":"Largely segregated parietofrontal connections linking rostral intraparietal cortex (areas AIP and VIP) and the ventral premotor cortex (areas F5 and F4)","volume":"128","author":"Luppino","year":"1999","journal-title":"Experimental Brain Research"},{"key":"bib24","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1152\/jn.1997.78.4.2226","article-title":"Object representation in the ventral premotor cortex (area F5) of the monkey","volume":"78","author":"Murata","year":"1997","journal-title":"Journal of Neurophysiology"},{"key":"bib25","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1152\/jn.2000.83.5.2580","article-title":"Selectivity for the shape, size, and orientation of objects for grasping in neurons of monkey parietal area AIP","volume":"83","author":"Murata","year":"2000","journal-title":"Journal of Neurophysiology"},{"key":"bib26","doi-asserted-by":"crossref","first-page":"8174","DOI":"10.1523\/JNEUROSCI.21-20-08174.2001","article-title":"From three-dimensional space vision to prehensile hand movements: the lateral intraparietal area links the area V3A and the anterior intraparietal area in macaques","volume":"21","author":"Nakamura","year":"2001","journal-title":"Journal of Neuroscience"},{"key":"bib27","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1302\/0301-620X.38B4.902","article-title":"The prehensile movements of the human hand","volume":"38-B","author":"Napier","year":"1956","journal-title":"Journal of Bone and Joint Surgery. British Volume"},{"key":"bib28","doi-asserted-by":"publisher","DOI":"10.17226\/10732","volume-title":"Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research","author":"National Research Council","year":"2003"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"8220","DOI":"10.1523\/JNEUROSCI.0623-11.2011","article-title":"Grasping-related functional magnetic resonance imaging brain responses in the macaque monkey","volume":"31","author":"Nelissen","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"3757","DOI":"10.1523\/JNEUROSCI.5158-10.2011","article-title":"Coordination of hand shape","volume":"31","author":"Pesyna","year":"2011","journal-title":"Journal of Neuroscience"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1162\/089976604774201631","article-title":"Unsupervised spike detection and sorting with wavelets and superparamagnetic clustering","volume":"16","author":"Quiroga","year":"2004","journal-title":"Neural Computation"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1152\/jn.00463.2005","article-title":"Functional properties of grasping-related neurons in the ventral premotor area F5 of the macaque monkey","volume":"95","author":"Raos","year":"2006","journal-title":"Journal of Neurophysiology"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1073\/pnas.0808362106","article-title":"Subdivisions of primary motor cortex based on cortico-motoneuronal cells","volume":"106","author":"Rathelot","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/S0896-6273(01)00423-8","article-title":"The cortical motor system","volume":"31","author":"Rizzolatti","year":"2001","journal-title":"Neuron"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/cercor\/5.5.429","article-title":"Neural mechanisms of visual guidance of hand action in the parietal cortex of the monkey","volume":"5","author":"Sakata","year":"1995","journal-title":"Cerebral Cortex"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"17079","DOI":"10.1523\/JNEUROSCI.2558-10.2010","article-title":"Encoding of coordinated grasp trajectories in primary motor cortex","volume":"30","author":"Saleh","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"026025","DOI":"10.1088\/1741-2560\/9\/2\/026025","article-title":"A new method of accurate hand- and arm-tracking for small primates","volume":"9","author":"Schaffelhofer","year":"2012","journal-title":"Journal of Neural Engineering"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1523\/JNEUROSCI.3594-14.2015","article-title":"Decoding a wide range of hand configurations from macaque motor, premotor, and parietal cortices","volume":"35","author":"Schaffelhofer","year":"2015","journal-title":"Journal of Neuroscience"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1109\/TNSRE.2014.2364776","article-title":"Musculoskeletal representation of a large repertoire of hand grasping actions in primates","volume":"23","author":"Schaffelhofer","year":"2015","journal-title":"IEEE Transactions on Neural Systems and Rehabilitation Engineering"},{"key":"bib40","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1152\/jn.1991.65.6.1381","article-title":"Individuated finger movements of rhesus monkeys: a means of quantifying the independence of the digits","volume":"65","author":"Schieber","year":"1991","journal-title":"Journal of Neurophysiology"},{"key":"bib41","doi-asserted-by":"crossref","first-page":"9038","DOI":"10.1523\/JNEUROSCI.18-21-09038.1998","article-title":"Partial inactivation of the primary motor cortex hand area: effects on individuated finger movements","volume":"18","author":"Schieber","year":"1998","journal-title":"Journal of Neuroscience"},{"key":"bib42","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1123\/mcj.3.3.237","article-title":"A new view on grasping","volume":"3","author":"Smeets","year":"1999","journal-title":"Motor Control"},{"key":"bib43","doi-asserted-by":"publisher","first-page":"10961","DOI":"10.1523\/JNEUROSCI.1956-08.2008","article-title":"Selectivity for grasp in local field potential and single neuron activity recorded simultaneously from M1 and F5 in the awake macaque monkey","volume":"28","author":"Spinks","year":"2008","journal-title":"Journal of Neuroscience"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF00232190","article-title":"Parietal cortex neurons of the monkey related to the visual guidance of hand movement","volume":"83","author":"Taira","year":"1990","journal-title":"Experimental Brain Research"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1146\/annurev.ne.19.030196.000545","article-title":"Inferotemporal cortex and object vision","volume":"19","author":"Tanaka","year":"1996","journal-title":"Annual Review of Neuroscience"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"12038","DOI":"10.1523\/JNEUROSCI.1790-12.2012","article-title":"Selectivity for three-dimensional shape and grasping-related activity in the macaque ventral premotor cortex","volume":"32","author":"Theys","year":"2012","journal-title":"Journal of Neuroscience"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1152\/jn.00248.2011","article-title":"Selectivity for three-dimensional contours and surfaces in the anterior intraparietal area","volume":"107","author":"Theys","year":"2012","journal-title":"Journal of Neurophysiology"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1162\/jocn_a_00332","article-title":"Three-dimensional shape coding in grasping circuits: a comparison between the anterior intraparietal area and ventral premotor area F5a","volume":"25","author":"Theys","year":"2013","journal-title":"Journal of Cognitive Neuroscience"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1152\/jn.01094.2006","article-title":"Simultaneous recording of macaque premotor and primary motor cortex neuronal populations reveals different functional contributions to visuomotor grasp","volume":"98","author":"Umilta","year":"2007","journal-title":"Journal of Neurophysiology"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"10888","DOI":"10.1523\/JNEUROSCI.1574-15.2015","article-title":"Linking Objects to Actions: Encoding of Target Object and Grasping Strategy in Primate Ventral Premotor Cortex","volume":"35","author":"Vargas-Irwin","year":"2015","journal-title":"Journal of Neuroscience"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/15278\/elife-15278-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/15278\/elife-15278-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/15278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:51:03Z","timestamp":1697057463000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/15278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,26]]},"references-count":50,"alternative-id":["10.7554\/eLife.15278"],"URL":"https:\/\/doi.org\/10.7554\/elife.15278","archive":["CLOCKSS"],"relation":{"has-review":[{"id-type":"doi","id":"10.7554\/eLife.15278.023","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.15278.024","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726578812.793522831","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,26]]},"article-number":"e15278"}}