{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T08:04:47Z","timestamp":1772265887337,"version":"3.50.1"},"reference-count":20,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T00:00:00Z","timestamp":1494288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["VR-NT 2010-4284"],"award-info":[{"award-number":["VR-NT 2010-4284"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"crossref","award":["VR-U 2015-03442"],"award-info":[{"award-number":["VR-U 2015-03442"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["106158\/Z\/14\/Z"],"award-info":[{"award-number":["106158\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome","doi-asserted-by":"publisher","award":["100087\/Z\/12\/Z"],"award-info":[{"award-number":["100087\/Z\/12\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elifesciences.org"],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    <jats:italic>Salmonella<\/jats:italic>\n                    Typhi is the causative agent of typhoid. Typhoid is diagnosed by blood culture, a method that lacks sensitivity, portability and speed. We have previously shown that specific metabolomic profiles can be detected in the blood of typhoid patients from Nepal (N\u00e4sstr\u00f6m et al., 2014). Here, we performed mass spectrometry on plasma from Bangladeshi and Senegalese patients with culture confirmed typhoid fever, clinically suspected typhoid, and other febrile diseases including malaria. After applying supervised pattern recognition modelling, we could significantly distinguish metabolite profiles in plasma from the culture confirmed typhoid patients. After comparing the direction of change and degree of multivariate significance, we identified 24 metabolites that were consistently up- or down regulated in a further Bangladeshi\/Senegalese validation cohort, and the Nepali cohort from our previous work. We have identified and validated a metabolite panel that can distinguish typhoid from other febrile diseases, providing a new approach for typhoid diagnostics.\n                  <\/jats:p>","DOI":"10.7554\/elife.15651","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T20:00:20Z","timestamp":1494273620000},"update-policy":"https:\/\/doi.org\/10.7554\/elife.15651","source":"Crossref","is-referenced-by-count":12,"title":["Reproducible diagnostic metabolites in plasma from typhoid fever patients in Asia and Africa"],"prefix":"10.7554","volume":"6","author":[{"given":"Elin","family":"N\u00e4sstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Chemistry, Computational Life Science Cluster, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M","family":"Parry","sequence":"additional","affiliation":[{"name":"Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, 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the Netherlands"},{"name":"Center for Experimental Molecular Medicine (CEMM), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena","family":"Rzhepishevska","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Computational Life Science Cluster, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Marks","sequence":"additional","affiliation":[{"name":"The International Vaccine Institute, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Panzner","sequence":"additional","affiliation":[{"name":"The International Vaccine Institute, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Im","sequence":"additional","affiliation":[{"name":"The International Vaccine Institute, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyonjin","family":"Jeon","sequence":"additional","affiliation":[{"name":"The International Vaccine Institute, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seeun","family":"Park","sequence":"additional","affiliation":[{"name":"The International Vaccine Institute, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zabeen","family":"Chaudhury","sequence":"additional","affiliation":[{"name":"The International Vaccine Institute, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniruddha","family":"Ghose","sequence":"additional","affiliation":[{"name":"Chittagong Medical College Hospital, Chittagong, 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Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy E","family":"Thwaites","sequence":"additional","affiliation":[{"name":"The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University, Oxford, United Kingdom"},{"name":"Centre for Tropical Medicine, Oxford University, Oxford, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abul","family":"Faiz","sequence":"additional","affiliation":[{"name":"Malaria Research Group and Dev Care Foundation, Dhaka, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Antti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Computational Life Science Cluster, Ume\u00e5 University, Ume\u00e5, 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