{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:01:02Z","timestamp":1778893262434,"version":"3.51.4"},"reference-count":11,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T00:00:00Z","timestamp":1462752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Neurons in the brainstem are the input for a neural circuit that integrates nutrient signals to control feeding behavior.<\/jats:p>","DOI":"10.7554\/elife.16393","type":"journal-article","created":{"date-parts":[[2016,5,9]],"date-time":"2016-05-09T10:59:21Z","timestamp":1462791561000},"source":"Crossref","is-referenced-by-count":5,"title":["Decoding obesity in the brainstem"],"prefix":"10.7554","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-8372","authenticated-orcid":true,"given":"Jonathan","family":"Cedernaes","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1602-8601","authenticated-orcid":true,"given":"Joseph","family":"Bass","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4374","published-online":{"date-parts":[[2016,5,9]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1038\/nn.3767","article-title":"Central amygdala PKC-\u03b4+ neurons mediate the influence of multiple anorexigenic signals","volume":"17","author":"Cai","year":"2014","journal-title":"Nature Neuroscience"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"e012225","DOI":"10.7554\/eLife.12225","article-title":"Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit","volume":"5","author":"D'Agostino","year":"2016","journal-title":"eLife"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nn1214","article-title":"Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system","volume":"7","author":"Fan","year":"2004","journal-title":"Nature Neuroscience"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1038\/nn.3861","article-title":"Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance","volume":"17","author":"Flak","year":"2014","journal-title":"Nature Neuroscience"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/245323a0","article-title":"Cholecystokinin elicits satiety in rats with open gastric fistulas","volume":"245","author":"Gibbs","year":"1973","journal-title":"Nature"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.cmet.2012.06.015","article-title":"Hindbrain neurons as an essential hub in the neuroanatomically distributed control of energy balance","volume":"16","author":"Grill","year":"2012","journal-title":"Cell Metabolism"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cmet.2009.10.009","article-title":"Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation","volume":"11","author":"Hayes","year":"2010","journal-title":"Cell Metabolism"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1007\/s00125-012-2654-6","article-title":"Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity\/diabetes","volume":"55","author":"Irwin","year":"2012","journal-title":"Diabetologia"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1172\/JCI200522081","article-title":"Leptin action in the forebrain regulates the hindbrain response to satiety signals","volume":"115","author":"Morton","year":"2005","journal-title":"Journal of Clinical Investigation"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1056\/NEJMoa1105816","article-title":"Long-term persistence of hormonal adaptations to weight loss","volume":"365","author":"Sumithran","year":"2011","journal-title":"New England Journal of Medicine"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nature10899","article-title":"Deciphering a neuronal circuit that mediates appetite","volume":"483","author":"Wu","year":"2012","journal-title":"Nature"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/16393\/elife-16393-v1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/16393\/elife-16393-v1.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/16393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:52:41Z","timestamp":1697071961000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/16393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,9]]},"references-count":11,"alternative-id":["10.7554\/eLife.16393"],"URL":"https:\/\/doi.org\/10.7554\/elife.16393","archive":["CLOCKSS"],"relation":{},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,9]]},"article-number":"e16393"}}