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While the function of TorsinA remains elusive, the \u0394E mutation is known to diminish binding of two TorsinA ATPase activators: lamina-associated protein 1 (LAP1) and its paralog, luminal domain like LAP1 (LULL1). Using a nanobody as a crystallization chaperone, we obtained a 1.4 \u00c5 crystal structure of human TorsinA in complex with LULL1. This nanobody likewise stabilized the weakened TorsinA\u0394E-LULL1 interaction, which enabled us to solve its structure at 1.4 \u00c5 also. A comparison of these structures shows, in atomic detail, the subtle differences in activator interactions that separate the healthy from the diseased state. This information may provide a structural platform for drug development, as a small molecule that rescues TorsinA\u0394E could serve as a cure for primary dystonia.<\/jats:p>","DOI":"10.7554\/elife.17983","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T07:59:28Z","timestamp":1470297568000},"source":"Crossref","is-referenced-by-count":66,"title":["Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia"],"prefix":"10.7554","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-2742","authenticated-orcid":true,"given":"F Esra","family":"Demircioglu","sequence":"first","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, Cambridge, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A","family":"Sosa","sequence":"additional","affiliation":[{"name":"Department of Biology, Massachusetts Institute of Technology, 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