{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:08:24Z","timestamp":1792804104213,"version":"4.5.0"},"reference-count":58,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["CA084179"],"award-info":[{"award-number":["CA084179"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["CA139980"],"award-info":[{"award-number":["CA139980"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["2012-RUG-5549"],"award-info":[{"award-number":["2012-RUG-5549"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["ERC advanced ROOTS"],"award-info":[{"award-number":["ERC advanced ROOTS"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["Longterm fellowship"],"award-info":[{"award-number":["Longterm fellowship"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stichting Kinder Oncologie Groningen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a selective advantage. CIN can be induced in the mouse by inactivating the spindle assembly checkpoint. This is lethal in the germline but we show here that adult T cells and hepatocytes can survive conditional inactivation of the Mad2l1 SAC gene and resulting CIN. This causes rapid onset of acute lymphoblastic leukemia (T-ALL) and progressive development of hepatocellular carcinoma (HCC), both lethal diseases. The resulting DNA copy number variation and patterns of chromosome loss and gain are tumor-type specific, suggesting differential selective pressures on the two tumor cell types.<\/jats:p>","DOI":"10.7554\/elife.20873","type":"journal-article","created":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T09:00:23Z","timestamp":1490000423000},"source":"Crossref","is-referenced-by-count":60,"title":["Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma"],"prefix":"10.7554","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-3127","authenticated-orcid":true,"given":"Floris","family":"Foijer","sequence":"first","affiliation":[{"name":"European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"},{"name":"Department of Systems Biology, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee A","family":"Albacker","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Bakker","sequence":"additional","affiliation":[{"name":"European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana C","family":"Spierings","sequence":"additional","affiliation":[{"name":"European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie Z","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-4210","authenticated-orcid":true,"given":"Stephanie","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annegret","family":"Lutum-Jehle","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darin","family":"Takemoto","sequence":"additional","affiliation":[{"name":"Vertex Pharmaceuticals Incorporated, Cambridge, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hare","sequence":"additional","affiliation":[{"name":"Vertex Pharmaceuticals Incorporated, Cambridge, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brinley","family":"Furey","sequence":"additional","affiliation":[{"name":"Vertex Pharmaceuticals Incorporated, Cambridge, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick T","family":"Bronson","sequence":"additional","affiliation":[{"name":"Rodent Histopathology Core, Dana-Farber\/Harvard Cancer Center, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Lansdorp","sequence":"additional","affiliation":[{"name":"Terry Fox Laboratory, BC Cancer Agency, Vancouver, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Bradley","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K","family":"Sorger","sequence":"additional","affiliation":[{"name":"Department of Systems Biology, Harvard Medical School, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"bib1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1083\/jcb.200211048","article-title":"Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation","volume":"160","author":"Babu","year":"2003","journal-title":"The Journal of Cell Biology"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/ng1382","article-title":"BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice","volume":"36","author":"Baker","year":"2004","journal-title":"Nature Genetics"},{"key":"bib3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.ccr.2009.10.023","article-title":"Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity","volume":"16","author":"Baker","year":"2009","journal-title":"Cancer Cell"},{"key":"bib4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s13059-016-0971-7","article-title":"Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies","volume":"17","author":"Bakker","year":"2016","journal-title":"Genome Biology"},{"key":"bib5","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/ng1724","article-title":"Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin","volume":"38","author":"Boyden","year":"2006","journal-title":"Nature Genetics"},{"key":"bib6","doi-asserted-by":"publisher","first-page":"11296","DOI":"10.1073\/pnas.0505053102","article-title":"Generating chromosome instability through the simultaneous deletion of Mad2 and p53","volume":"102","author":"Burds","year":"2005","journal-title":"PNAS"},{"key":"bib7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.gde.2013.11.011","article-title":"The evolution of the unstable cancer genome","volume":"24","author":"Burrell","year":"2014","journal-title":"Current Opinion in Genetics & Development"},{"key":"bib8","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.molonc.2014.06.005","article-title":"Tumour heterogeneity and the evolution of polyclonal drug resistance","volume":"8","author":"Burrell","year":"2014","journal-title":"Molecular Oncology"},{"key":"bib9","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1158\/0008-5472.CAN-03-3119","article-title":"Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency","volume":"64","author":"Dai","year":"2004","journal-title":"Cancer Research"},{"key":"bib10","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.cell.2013.10.011","article-title":"Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome","volume":"155","author":"Davoli","year":"2013","journal-title":"Cell"},{"key":"bib11","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1126\/science.1253462","article-title":"Spatial and temporal diversity in genomic instability processes defines lung cancer evolution","volume":"346","author":"De Bruin","year":"2014","journal-title":"Science"},{"key":"bib12","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/S0092-8674(00)80875-2","article-title":"Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2","volume":"101","author":"Dobles","year":"2000","journal-title":"Cell"},{"key":"bib13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/356215a0","article-title":"Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours","volume":"356","author":"Donehower","year":"1992","journal-title":"Nature"},{"key":"bib14","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1002\/mc.2940140105","article-title":"Effects of genetic background on tumorigenesis in p53-deficient mice","volume":"14","author":"Donehower","year":"1995","journal-title":"Molecular Carcinogenesis"},{"key":"bib15","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nature09414","article-title":"The ploidy conveyor of mature hepatocytes as a source of genetic variation","volume":"467","author":"Duncan","year":"2010","journal-title":"Nature"},{"key":"bib16","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/gcc.2870070307","article-title":"Allelic loss at chromosome band 8p21.3-p22 is associated with progression of hepatocellular carcinoma","volume":"7","author":"Emi","year":"1993","journal-title":"Genes, Chromosomes and Cancer"},{"key":"bib17","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.1073\/pnas.1217388110","article-title":"Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells","volume":"110","author":"Foijer","year":"2013","journal-title":"PNAS"},{"key":"bib18","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.ccr.2005.10.021","article-title":"Mitogen requirement for cell cycle progression in the absence of pocket protein activity","volume":"8","author":"Foijer","year":"2005","journal-title":"Cancer Cell"},{"key":"bib19","doi-asserted-by":"publisher","first-page":"13427","DOI":"10.1073\/pnas.1400892111","article-title":"Chromosome instability induced by Mps1 and p53 mutation generates aggressive lymphomas exhibiting aneuploidy-induced stress","volume":"111","author":"Foijer","year":"2014","journal-title":"PNAS"},{"key":"bib20","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/nature04217","article-title":"Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells","volume":"437","author":"Fujiwara","year":"2005","journal-title":"Nature"},{"key":"bib21","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1038\/ncb1742","article-title":"Genomic stability and tumour suppression by the APC\/C cofactor Cdh1","volume":"10","author":"Garc\u00eda-Higuera","year":"2008","journal-title":"Nature Cell Biology"},{"key":"bib22","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1056\/NEJMoa1113205","article-title":"Intratumor heterogeneity and branched evolution revealed by multiregion sequencing","volume":"366","author":"Gerlinger","year":"2012","journal-title":"New England Journal of Medicine"},{"key":"bib23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1022>3.0.CO;2-V","article-title":"Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization","volume":"29","author":"Guan","year":"2000","journal-title":"Genes, Chromosomes and Cancer"},{"key":"bib24","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1096\/fasebj.7.10.8344491","article-title":"Genetic background alters the spectrum of tumors that develop in p53-deficient mice","volume":"7","author":"Harvey","year":"1993","journal-title":"FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology"},{"key":"bib25","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1159\/000151712","article-title":"Losses of chromosome arms 4q, 8p, 13q and gain of 8q are correlated with increasing chromosomal instability in hepatocellular carcinoma","volume":"75","author":"Hertz","year":"2008","journal-title":"Pathobiology"},{"key":"bib26","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/350427a0","article-title":"Mutational hotspot in the p53 gene in human hepatocellular carcinomas","volume":"350","author":"Hsu","year":"1991","journal-title":"Nature"},{"key":"bib27","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1158\/0008-5472.CAN-06-3326","article-title":"Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice","volume":"67","author":"Iwanaga","year":"2007","journal-title":"Cancer Research"},{"key":"bib28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","article-title":"Tumor spectrum analysis in p53-mutant mice","volume":"4","author":"Jacks","year":"1994","journal-title":"Current Biology"},{"key":"bib29","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/35101065","article-title":"Chromosome segregation and cancer: cutting through the mystery","volume":"1","author":"Jallepalli","year":"2001","journal-title":"Nature Reviews Cancer"},{"key":"bib30","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1084\/jem.20091071","article-title":"Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia","volume":"207","author":"Jones","year":"2010","journal-title":"The Journal of Experimental Medicine"},{"key":"bib31","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/ng747","article-title":"Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer","volume":"29","author":"Jonkers","year":"2001","journal-title":"Nature Genetics"},{"key":"bib32","doi-asserted-by":"publisher","first-page":"8699","DOI":"10.1073\/pnas.0401142101","article-title":"Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint","volume":"101","author":"Kops","year":"2004","journal-title":"PNAS"},{"key":"bib33","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1242\/jcs.022822","article-title":"The R246S hot-spot p53 mutant exerts dominant-negative effects in embryonic stem cells in vitro and in vivo","volume":"121","author":"Lee","year":"2008","journal-title":"Journal of Cell Science"},{"key":"bib34","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.3748\/wjg.14.6915","article-title":"Mouse models in liver cancer research: a review of current literature","volume":"14","author":"Leenders","year":"2008","journal-title":"World Journal of Gastroenterology"},{"key":"bib35","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/386623a0","article-title":"Genetic instability in colorectal cancers","volume":"386","author":"Lengauer","year":"1997","journal-title":"Nature"},{"key":"bib36","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1083\/jcb.200904020","article-title":"Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice","volume":"185","author":"Li","year":"2009","journal-title":"The Journal of Cell Biology"},{"key":"bib37","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nbt.2892","article-title":"Whole-exome sequencing of circulating tumor cells provides a window into metastatic prostate cancer","volume":"32","author":"Lohr","year":"2014","journal-title":"Nature Biotechnology"},{"key":"bib38","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/S0888-7543(03)00035-1","article-title":"Global up-regulation of chromosome 21 gene expression in the developing down syndrome brain","volume":"81","author":"Mao","year":"2003","journal-title":"Genomics"},{"key":"bib39","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/35053094","article-title":"MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells","volume":"409","author":"Michel","year":"2001","journal-title":"Nature"},{"key":"bib40","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/357161a0","article-title":"Profound block in thymocyte development in mice lacking p56lck","volume":"357","author":"Molina","year":"1992","journal-title":"Nature"},{"key":"bib41","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fonc.2013.00148","article-title":"Cancer karyotypes: survival of the fittest","volume":"3","author":"Nicholson","year":"2013","journal-title":"Frontiers in Oncology"},{"key":"bib42","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.devcel.2007.08.008","article-title":"Bub1 maintains centromeric cohesion by activation of the spindle checkpoint","volume":"13","author":"Perera","year":"2007","journal-title":"Developmental Cell"},{"key":"bib43","first-page":"603","article-title":"Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene","volume":"9","author":"Purdie","year":"1994","journal-title":"Oncogene"},{"key":"bib44","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S1534-5807(02)00255-1","article-title":"Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E","volume":"3","author":"Putkey","year":"2002","journal-title":"Developmental Cell"},{"key":"bib45","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1083\/jcb.130.4.941","article-title":"The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores","volume":"130","author":"Rieder","year":"1995","journal-title":"The Journal of Cell Biology"},{"key":"bib46","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature08803","article-title":"Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal","volume":"464","author":"Sotillo","year":"2010","journal-title":"Nature"},{"key":"bib47","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1023\/B:CHRO.0000036610.78380.51","article-title":"The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation","volume":"12","author":"Taylor","year":"2004","journal-title":"Chromosome Research"},{"key":"bib48","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.cell.2010.08.038","article-title":"Identification of aneuploidy-tolerating mutations","volume":"143","author":"Torres","year":"2010","journal-title":"Cell"},{"key":"bib49","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1126\/science.1142210","article-title":"Effects of aneuploidy on cellular physiology and cell division in haploid yeast","volume":"317","author":"Torres","year":"2007","journal-title":"Science"},{"key":"bib50","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s13059-016-0976-2","article-title":"Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons","volume":"17","author":"van den Bos","year":"2016","journal-title":"Genome Biology"},{"key":"bib51","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1182\/blood-2003-06-2158","article-title":"BUBR1 deficiency results in abnormal megakaryopoiesis","volume":"103","author":"Wang","year":"2004","journal-title":"Blood"},{"key":"bib52","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/nature13600","article-title":"Clonal evolution in breast cancer revealed by single nucleus genome sequencing","volume":"512","author":"Wang","year":"2014","journal-title":"Nature"},{"key":"bib53","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/dvg.20568","article-title":"Cre activity in fetal albCre mouse hepatocytes: utility for developmental studies","volume":"47","author":"Weisend","year":"2009","journal-title":"Genesis"},{"key":"bib54","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1126\/science.1160058","article-title":"Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells","volume":"322","author":"Williams","year":"2008","journal-title":"Science"},{"key":"bib55","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/hep.510270113","article-title":"Control of mouse hepatocyte proliferation and ploidy by p53 and p53ser246 mutation in vivo","volume":"27","author":"Yin","year":"1998","journal-title":"Hepatology"},{"key":"bib56","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1038\/ng.2760","article-title":"Pan-cancer patterns of somatic copy number alteration","volume":"45","author":"Zack","year":"2013","journal-title":"Nature Genetics"},{"key":"bib57","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.cell.2006.05.030","article-title":"Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach","volume":"125","author":"Zender","year":"2006","journal-title":"Cell"},{"key":"bib58","doi-asserted-by":"publisher","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: an integrated system for exploring gene sets in various biological contexts","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Research"}],"container-title":["eLife"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cdn.elifesciences.org\/articles\/20873\/elife-20873-v2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cdn.elifesciences.org\/articles\/20873\/elife-20873-v2.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/elifesciences.org\/articles\/20873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:47:34Z","timestamp":1697057254000},"score":1,"resource":{"primary":{"URL":"https:\/\/elifesciences.org\/articles\/20873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,20]]},"references-count":58,"alternative-id":["10.7554\/eLife.20873"],"URL":"https:\/\/doi.org\/10.7554\/elife.20873","archive":["CLOCKSS"],"relation":{"references":[{"id-type":"uri","id":"https:\/\/portal.gdc.cancer.gov\/search\/s?facetTab=cases","asserted-by":"subject"}],"is-supplemented-by":[{"id-type":"uri","id":"https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?&acc=GSE63689","asserted-by":"subject"},{"id-type":"uri","id":"https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE63100","asserted-by":"subject"},{"id-type":"uri","id":"https:\/\/www.ncbi.nlm.nih.gov\/sra\/?term=SRA191233","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.7554\/eLife.20873.028","asserted-by":"object"},{"id-type":"doi","id":"10.7554\/eLife.20873.027","asserted-by":"object"}]},"ISSN":["2050-084X"],"issn-type":[{"value":"2050-084X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,20]]},"article-number":"e20873"}}