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The elevated viral load was associated with the release of high mobility group box-1 (HMGB1) which triggered airway smooth muscle remodelling in early-life. Re-infection with PVM in later-life induced many of the cardinal features of asthma in the absence of eosinophilic or neutrophilic inflammation. Anti-HMGB1 mitigated both early-life viral disease and asthma-like features, highlighting HMGB1 as a possible novel therapeutic target.<\/jats:p>","DOI":"10.7554\/elife.21199","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T12:00:34Z","timestamp":1484740834000},"source":"Crossref","is-referenced-by-count":25,"title":["RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma"],"prefix":"10.7554","volume":"6","author":[{"given":"Jaisy","family":"Arikkatt","sequence":"first","affiliation":[{"name":"School of Biomedical Science, University of Queensland, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Ashik","family":"Ullah","sequence":"additional","affiliation":[{"name":"School of Biomedical Science, University of Queensland, Brisbane, Australia"},{"name":"Woolcock Institute of Medical Research, Sydney Medical School, University of Sydney, New South Wales, 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