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The main adverse effect of primaquine is erythrocyte age and dose-dependent acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd). As testing for G6PDd is often unavailable, this limits the use of primaquine for radical cure. A compartmental model of the dynamics of red blood cell production and destruction was designed to characterise primaquine-induced haemolysis using a holistic Bayesian analysis of all published data and was used to predict a safer alternative to the currently recommended once weekly 0.75 mg\/kg regimen for G6PDd. The model suggests that a step-wise increase in daily administered primaquine dose would be relatively safe in G6PDd. If this is confirmed, then were this regimen to be recommended for radical cure patients would not require testing for G6PDd in areas where G6PDd Viangchan or milder variants are prevalent.<\/jats:p>","DOI":"10.7554\/elife.23061","type":"journal-article","created":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T08:00:11Z","timestamp":1486108811000},"source":"Crossref","is-referenced-by-count":58,"title":["Modelling primaquine-induced haemolysis in G6PD deficiency"],"prefix":"10.7554","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-0325","authenticated-orcid":true,"given":"James","family":"Watson","sequence":"first","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter RJ","family":"Taylor","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1357-4495","authenticated-orcid":true,"given":"Didier","family":"Menard","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'Epid\u00e9miologie Mol\u00e9culaire du Paludisme, Institut Pasteur du Cambodge, Phnom Penh, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sim","family":"Kheng","sequence":"additional","affiliation":[{"name":"National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-1978","authenticated-orcid":true,"given":"Nicholas J","family":"White","sequence":"additional","affiliation":[{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4374","published-online":{"date-parts":[[2017,2,4]]},"reference":[{"key":"bib1","first-page":"621","article-title":"Mitigation of the haemolytic effect of primaquine and enhancement of its action against exoerythrocytic forms of the chesson strain of piasmodium vivax by intermittent regimens of drug administration: a preliminary report","volume":"22","author":"Alving","year":"1960","journal-title":"Bulletin of the World Health Organization"},{"key":"bib2","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1093\/infdis\/jiv508","article-title":"Estimation of the antirelapse efficacy of tafenoquine, using Plasmodium vivax Genotyping","volume":"213","author":"Beck","year":"2016","journal-title":"Journal of Infectious Diseases"},{"key":"bib3","first-page":"439","article-title":"The hemolytic effect of primaquine. 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