{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:43:35Z","timestamp":1792496615256,"version":"4.5.0"},"reference-count":43,"publisher":"eLife Sciences Publications, Ltd","license":[{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T00:00:00Z","timestamp":1494460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000912","name":"March of Dimes Foundation","doi-asserted-by":"publisher","award":["1-FY14-219"],"award-info":[{"award-number":["1-FY14-219"]}],"id":[{"id":"10.13039\/100000912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL124392"],"award-info":[{"award-number":["R01 HL124392"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003392","name":"Sjogren's Syndrome Foundation","doi-asserted-by":"publisher","award":["Research Grant"],"award-info":[{"award-number":["Research Grant"]}],"id":[{"id":"10.13039\/100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R21 DE024954"],"award-info":[{"award-number":["R21 DE024954"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1-TR001430"],"award-info":[{"award-number":["UL1-TR001430"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Salivary glands, such as submandibular glands (SMGs), are composed of branched epithelial ductal networks that terminate in acini that together produce, transport and secrete saliva. Here, we show that the transcriptional regulator Yap, a key effector of the Hippo pathway, is required for the proper patterning and morphogenesis of SMG epithelium. Epithelial deletion of Yap in developing SMGs results in the loss of ductal structures, arising from reduced expression of the EGF family member Epiregulin, which we show is required for the expansion of Krt5\/Krt14-positive ductal progenitors. We further show that epithelial deletion of the Lats1 and Lats2 genes, which encode kinases that restrict nuclear Yap localization, results in morphogenesis defects accompanied by an expansion of Krt5\/Krt14-positive cells. Collectively, our data indicate that Yap-induced Epiregulin signaling promotes the identity of SMG ductal progenitors and that removal of nuclear Yap by Lats1\/2-mediated signaling is critical for proper ductal maturation.<\/jats:p>","DOI":"10.7554\/elife.23499","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T09:00:46Z","timestamp":1494493246000},"source":"Crossref","is-referenced-by-count":48,"title":["The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland"],"prefix":"10.7554","volume":"6","author":[{"given":"Aleksander D","family":"Szymaniak","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Boston University School of Medicine, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjuan","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Boston University School of Medicine, Boston, United States"},{"name":"Department of Molecular and Cell Biology, Boston University School of Dental Medicine, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon E","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Boston University School of Medicine, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C","family":"Gower","sequence":"additional","affiliation":[{"name":"Clinical and Translational Science Institute, Boston University, Boston, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor L","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Immunology Research, Biogen, Cambridge, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mingueneau","sequence":"additional","affiliation":[{"name":"Immunology Research, Biogen, Cambridge, United 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